PMID- 30944598
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 17
IP  - 5
DP  - 2019 May
TI  - Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and 
      other T-cell skin lymphoma.
PG  - 4055-4059
LID - 10.3892/ol.2019.10097 [doi]
AB  - Dendritic cells (DCs) are antigen-presenting cells with an important role in the 
      innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans 
      cells, dermal DCs and plasmacytoid DCs) are involved in immune activation in 
      inflammatory benign lesions, as well as in malignant lymphoid proliferations. 
      Density and distribution of DCs in the dermal infiltrate can be helpful to 
      differentiate benign, reactive infiltrate from malignant nature of the lymphoid 
      population. We performed a retrospective study including 149 patients: 35 with 
      mycosis fungoides, 35 with spongiotic dermatitis, 35 with psoriasis, 35 with 
      lupus and 9 with cutaneous T-cell lymphomas (other than mycosis fungoides), 
      diagnosed using histopathological and immunohistochemical stains. Density and 
      distribution of DCs were evaluated using specific markers (CD1a, CD11c and 
      langerin). In all cases, numerous DCs were identified in the dermal infiltrate. 
      Their number was significantly increased in mycosis fungoides and T-cell 
      lymphomas and moderately increased in inflammatory lesions. Variable patterns of 
      distribution were identified such as clusters of DCs with arachnoid extension in 
      mycosis fungoides, nodular pattern in inflammatory lesions and dispersed 
      distribution with peripheric accumulation in T-skin lymphomas. Therefore, 
      immunohistochemical characterization of DC distribution can be an adjuvant tool 
      in differential diagnosis in inflammatory dermatosis and skin lymphomas.
FAU - Cioplea, Mirela
AU  - Cioplea M
AD  - Department of Pathology, Colentina University Hospital, 020125 Bucharest, 
      Romania.
FAU - Caruntu, Costin
AU  - Caruntu C
AD  - Department of Physiology, 'Carol Davila' University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
FAU - Zurac, Sabina
AU  - Zurac S
AD  - Department of Pathology, Colentina University Hospital, 020125 Bucharest, 
      Romania.
AD  - Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
FAU - Bastian, Alexandra
AU  - Bastian A
AD  - Department of Pathology, Colentina University Hospital, 020125 Bucharest, 
      Romania.
AD  - Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
FAU - Sticlaru, Liana
AU  - Sticlaru L
AD  - Department of Pathology, Colentina University Hospital, 020125 Bucharest, 
      Romania.
FAU - Cioroianu, Alexandra
AU  - Cioroianu A
AD  - Department of Pathology, Colentina University Hospital, 020125 Bucharest, 
      Romania.
FAU - Boda, Daniel
AU  - Boda D
AD  - Excellence Center in Dermatology, 'Carol Davila' University of Medicine and 
      Pharmacy, 050474 Bucharest, Romania.
AD  - National Institute of Diabetes, Nutrition and Metabolic Diseases 'Prof. Dr. 
      Nicolae Paulescu', 020475 Bucharest, Romania.
FAU - Jugulete, Gheorghita
AU  - Jugulete G
AD  - Department of Infectious Diseases, 'Carol Davila' University of Medicine and 
      Pharmacy, 050474 Bucharest, Romania.
AD  - National Institute of Infectious Diseases 'Prof. Dr. Matei Bals', 021105 
      Bucharest, Romania.
FAU - Nichita, Luciana
AU  - Nichita L
AD  - Department of Pathology, Colentina University Hospital, 020125 Bucharest, 
      Romania.
AD  - Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
FAU - Popp, Cristiana
AU  - Popp C
AD  - Department of Pathology, Colentina University Hospital, 020125 Bucharest, 
      Romania.
LA  - eng
PT  - Journal Article
DEP - 20190301
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6444333
OTO - NOTNLM
OT  - cutaneous T cells lymphoma
OT  - dendritic cells
OT  - inflammatory dermatosis
EDAT- 2019/04/05 06:00
MHDA- 2019/04/05 06:01
PMCR- 2019/03/01
CRDT- 2019/04/05 06:00
PHST- 2018/09/10 00:00 [received]
PHST- 2019/01/10 00:00 [accepted]
PHST- 2019/04/05 06:00 [entrez]
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2019/04/05 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - OL-0-0-10097 [pii]
AID - 10.3892/ol.2019.10097 [doi]
PST - ppublish
SO  - Oncol Lett. 2019 May;17(5):4055-4059. doi: 10.3892/ol.2019.10097. Epub 2019 Mar 
      1.