PMID- 30945100
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20220201
IS  - 2509-9280 (Electronic)
IS  - 2509-9280 (Linking)
VI  - 3
IP  - 1
DP  - 2019 Apr 3
TI  - Timing optimization of low-dose first-pass analysis dynamic CT myocardial 
      perfusion measurement: validation in a swine model.
PG  - 16
LID - 10.1186/s41747-019-0093-6 [doi]
LID - 16
AB  - BACKGROUND: Myocardial perfusion measurement with a low-dose first-pass analysis 
      (FPA) dynamic computed tomography (CT) perfusion technique depends upon 
      acquisition of two whole-heart volume scans at the base and peak of the aortic 
      enhancement. Hence, the objective of this study was to validate an optimal timing 
      protocol for volume scan acquisition at the base and peak of the aortic 
      enhancement. METHODS: Contrast-enhanced CT of 28 Yorkshire swine (weight, 
      55 +/- 24 kg, mean +/- standard deviation) was performed under rest and stress 
      conditions over 20-30 s to capture the aortic enhancement curves. From these 
      curves, an optimal timing protocol was simulated, where one volume scan was 
      acquired at the base of the aortic enhancement while a second volume scan was 
      acquired at the peak of the aortic enhancement. Low-dose FPA perfusion 
      measurements (P(FPA)) were then derived and quantitatively compared to the 
      previously validated retrospective FPA perfusion measurements as a reference 
      standard (P(REF)). The 32-cm diameter volume CT dose index, [Formula: see text] 
      and size-specific dose estimate (SSDE) of the low-dose FPA perfusion protocol 
      were also determined. RESULTS: P(FPA) were related to the reference standard by 
      P(FPA) = 0.95 . P(REF) + 0.07 (r = 0.94, root-mean-square error = 0.27 mL/min/g, 
      root-mean-square deviation = 0.04 mL/min/g). The [Formula: see text] and SSDE of 
      the low-dose FPA perfusion protocol were 9.2 mGy and 14.6 mGy, respectively. 
      CONCLUSIONS: An optimal timing protocol for volume scan acquisition at the base 
      and peak of the aortic enhancement was retrospectively validated and has the 
      potential to be used to implement an accurate, low-dose, FPA perfusion technique.
FAU - Hubbard, Logan
AU  - Hubbard L
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, Irvine, CA, 92697, USA.
FAU - Malkasian, Shant
AU  - Malkasian S
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, Irvine, CA, 92697, USA.
FAU - Zhao, Yixiao
AU  - Zhao Y
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, Irvine, CA, 92697, USA.
FAU - Abbona, Pablo
AU  - Abbona P
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, Irvine, CA, 92697, USA.
FAU - Molloi, Sabee
AU  - Molloi S
AD  - Department of Radiological Sciences, Medical Sciences I, B-140, University of 
      California, Irvine, Irvine, CA, 92697, USA. symolloi@uci.edu.
LA  - eng
GR  - F30 HL137288/HL/NHLBI NIH HHS/United States
GR  - T32 GM008620/GM/NIGMS NIH HHS/United States
GR  - T32 HL116270/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20190403
PL  - England
TA  - Eur Radiol Exp
JT  - European radiology experimental
JID - 101721752
SB  - IM
MH  - Animals
MH  - Models, Animal
MH  - Myocardial Perfusion Imaging/*methods
MH  - Radiation Dosage
MH  - Swine
MH  - Time Factors
MH  - *Tomography, X-Ray Computed/methods
PMC - PMC6447643
OTO - NOTNLM
OT  - Animal experimentation
OT  - Coronary artery disease
OT  - Myocardium
OT  - Perfusion imaging
OT  - Tomography (x-ray computed)
COIS- ETHICS APPROVAL: The study was approved by the Institutional Animal Care and Use 
      Committee (#1997-1273-9). CONSENT FOR PUBLICATION: Not applicable COMPETING 
      INTERESTS: Sabee Molloi has previously received grants from Toshiba America 
      Medical Systems and Philips Medical Systems. The remaining authors do not have 
      any conflicts of interest to disclose. PUBLISHER'S NOTE: Springer Nature remains 
      neutral with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2019/04/05 06:00
MHDA- 2020/09/18 06:00
PMCR- 2019/04/03
CRDT- 2019/04/05 06:00
PHST- 2018/12/17 00:00 [received]
PHST- 2019/02/21 00:00 [accepted]
PHST- 2019/04/05 06:00 [entrez]
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
PHST- 2019/04/03 00:00 [pmc-release]
AID - 10.1186/s41747-019-0093-6 [pii]
AID - 93 [pii]
AID - 10.1186/s41747-019-0093-6 [doi]
PST - epublish
SO  - Eur Radiol Exp. 2019 Apr 3;3(1):16. doi: 10.1186/s41747-019-0093-6.