PMID- 30945205
OWN - NLM
STAT- MEDLINE
DCOM- 20200327
LR  - 20200327
IS  - 1179-2035 (Electronic)
IS  - 0112-1642 (Linking)
VI  - 49
IP  - 5
DP  - 2019 May
TI  - Exercise Frequency Determines Heart Rate Variability Gains in Older People: A 
      Meta-Analysis and Meta-Regression.
PG  - 719-729
LID - 10.1007/s40279-019-01097-7 [doi]
AB  - BACKGROUND: Previous studies have suggested that exercise training improves 
      cardiac autonomic drive in young and middle-aged adults. In this study, we 
      discuss the benefits for the elderly. OBJECTIVES: We aimed to establish whether 
      exercise still increases heart rate variability (HRV) beyond the age of 60 years, 
      and to identify which training factors influence HRV gains in this population. 
      METHODS: Interventional controlled and non-controlled studies were selected from 
      the PubMed, Ovid, Cochrane and Google Scholar databases. Only interventional 
      endurance training protocols involving healthy subjects aged 60 years and over, 
      and measuring at least one heart rate global or parasympathetic index, such as 
      the standard deviation of the normal-to-normal intervals (SDNN), total frequency 
      power (Ptot), root mean square of successive differences between adjacent NN 
      intervals (RMSSD), or high frequency power (HF) before and after the training 
      intervention, were included. HRV parameters were pooled separately from 
      short-term and 24 h recordings for analysis. Risks of bias were assessed using 
      the Methodological Index for Non-Randomized Studies and the Cochrane risk of bias 
      tool. A random-effects model was used to determine effect sizes (Hedges' g) for 
      changes, and heterogeneity was assessed using Q and I statistics. RESULTS: Twelve 
      studies, seven of which included a control group, including 218 and 111 subjects, 
      respectively (mean age 69.0 +/- 3.2 and 68.6 +/- 2.5), were selected for 
      meta-analysis. Including the 12 studies demonstrated homogeneous significant 
      effect sizes for short-term (ST)-SDNN and 24 h-SDNN, with effect sizes of 0.366 
      (95% CI 0.185-547) and 0.442 (95% CI 0.144-0.740), respectively. Controlled study 
      analysis demonstrated homogeneous significant effect sizes for 24 h-SDNN with 
      g = 0.721 (95% CI 0.184-1.257), and 24 h-Ptot with g = 0.731 (95% CI 
      0.195-1.267). Meta-regression analyses revealed positive relationships between 
      ST-SDNN effect sizes and training frequency ([Formula: see text] = 0.000; 
      [Formula: see text] = 0.000; p = 0.0462). CONCLUSION: This meta-analysis 
      demonstrates a positive effect of endurance-type exercise on autonomic regulation 
      in older adults. However, the selected studies expressed some risks of bias. We 
      conclude that chronic endurance exercise leads to HRV improvements in a linear 
      frequency-response relationship, encouraging the promotion of high-frequency 
      training programmes in older adults.
FAU - Raffin, Jeremy
AU  - Raffin J
AUID- ORCID: 0000-0003-1347-9113
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France. jeremy.raffin@live.fr.
AD  - Loire-Haute Loire Mutualite SSAM, 42100, Saint-Etienne, France. 
      jeremy.raffin@live.fr.
AD  - Department of Clinical and Exercise Physiology, University Hospital of 
      Saint-Etienne, 42055, Saint-Etienne Cedex 2, France. jeremy.raffin@live.fr.
FAU - Barthelemy, Jean-Claude
AU  - Barthelemy JC
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France.
AD  - Department of Clinical and Exercise Physiology, University Hospital of 
      Saint-Etienne, 42055, Saint-Etienne Cedex 2, France.
FAU - Dupre, Caroline
AU  - Dupre C
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France.
AD  - National Centre for Health Examination Prevention, CETAF, 42100, Saint-Etienne, 
      France.
FAU - Pichot, Vincent
AU  - Pichot V
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France.
AD  - Department of Clinical and Exercise Physiology, University Hospital of 
      Saint-Etienne, 42055, Saint-Etienne Cedex 2, France.
FAU - Berger, Mathieu
AU  - Berger M
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France.
FAU - Feasson, Leonard
AU  - Feasson L
AD  - Department of Clinical and Exercise Physiology, University Hospital of 
      Saint-Etienne, 42055, Saint-Etienne Cedex 2, France.
AD  - Univ Lyon, UJM-Saint-Etienne Inter-University Laboratory of Human Movement 
      Biology, EA 7424, 42023, Saint-Etienne, France.
FAU - Busso, Thierry
AU  - Busso T
AD  - Univ Lyon, UJM-Saint-Etienne Inter-University Laboratory of Human Movement 
      Biology, EA 7424, 42023, Saint-Etienne, France.
FAU - Da Costa, Antoine
AU  - Da Costa A
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France.
AD  - Department of Cardiology, University Hospital of Saint-Etienne, 42055, 
      Saint-Etienne Cedex 2, France.
FAU - Colvez, Alain
AU  - Colvez A
AD  - National Centre for Health Examination Prevention, CETAF, 42100, Saint-Etienne, 
      France.
FAU - Montuy-Coquard, Claude
AU  - Montuy-Coquard C
AD  - Loire-Haute Loire Mutualite SSAM, 42100, Saint-Etienne, France.
FAU - Bouvier, Remi
AU  - Bouvier R
AD  - Loire-Haute Loire Mutualite SSAM, 42100, Saint-Etienne, France.
FAU - Bongue, Bienvenu
AU  - Bongue B
AD  - National Centre for Health Examination Prevention, CETAF, 42100, Saint-Etienne, 
      France.
AD  - Chaire Sante des Aines, Univ. Lyon, Saint-Etienne, France.
FAU - Roche, Frederic
AU  - Roche F
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France.
AD  - Department of Clinical and Exercise Physiology, University Hospital of 
      Saint-Etienne, 42055, Saint-Etienne Cedex 2, France.
FAU - Hupin, David
AU  - Hupin D
AD  - Univ Lyon, UJM-Saint-Etienne Autonomic Nervous System Research Laboratory, EA 
      4607 SNA-EPIS, 42023, Saint-Etienne, France.
AD  - Department of Clinical and Exercise Physiology, University Hospital of 
      Saint-Etienne, 42055, Saint-Etienne Cedex 2, France.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - New Zealand
TA  - Sports Med
JT  - Sports medicine (Auckland, N.Z.)
JID - 8412297
SB  - IM
MH  - Aged
MH  - Aging
MH  - *Endurance Training
MH  - *Heart Rate
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - Regression Analysis
EDAT- 2019/04/05 06:00
MHDA- 2020/03/28 06:00
CRDT- 2019/04/05 06:00
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2020/03/28 06:00 [medline]
PHST- 2019/04/05 06:00 [entrez]
AID - 10.1007/s40279-019-01097-7 [pii]
AID - 10.1007/s40279-019-01097-7 [doi]
PST - ppublish
SO  - Sports Med. 2019 May;49(5):719-729. doi: 10.1007/s40279-019-01097-7.