PMID- 30945297
OWN - NLM
STAT- MEDLINE
DCOM- 20200605
LR  - 20221207
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 234
IP  - 11
DP  - 2019 Nov
TI  - Effect of pomegranate seed oil supplementation on the GLUT-4 gene expression and 
      glycemic control in obese people with type 2 diabetes: A randomized controlled 
      clinical trial.
PG  - 19621-19628
LID - 10.1002/jcp.28561 [doi]
AB  - Abnormality in glucose transporter type 4 (GLUT-4) function and insulin secretion 
      are the main causes of type 2 diabetes mellitus (T2DM). Due to adverse effects of 
      antidiabetic drugs, nowadays, nutraceuticals have been of much interest to 
      investigators. The aim of the present study was to determine the effect of 
      pomegranate seed oil (PSO) on the GLUT-4 gene expression and glycemic control in 
      obese people with T2DM. This randomized clinical trial was conducted on 52 obese 
      type 2 diabetic patients for 8 weeks in Tabriz, Iran, in 2018. Patients were 
      divided into the intervention group (n = 26; who consumed daily three capsules 
      containing 1 g PSO) and the placebo group (n = 26; the same amounts paraffin). 
      GLUT-4 gene expression and glycemic indices were evaluated by standard methods. 
      GLUT-4 gene expression was increased significantly in the PSO group. Within-group 
      changes in fasting blood sugar (FBS) and quantitative insulin sensitivity check 
      index were significant in the PSO group. After adjusting the age, gender, and 
      baseline values, FBS was significantly decreased. Insulin concentration, HbA1C, 
      HOMA-IR, and HOMA-beta did not manifest significant changes. PSO increased the 
      GLUT-4 gene expression in diabetic patients without any side effects. However, 
      future clinical studies are needed to confirm the obtained results.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Khajebishak, Yaser
AU  - Khajebishak Y
AD  - Talented Student Center, Student Research Committee, Nutrition Research Center, 
      Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Payahoo, Laleh
AU  - Payahoo L
AUID- ORCID: 0000-0001-8824-4832
AD  - Department of Nutrition, Maragheh University of Medical Sciences, Maragheh, Iran.
FAU - Alivand, Mohammadreza
AU  - Alivand M
AD  - Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Hamishehkar, Hamed
AU  - Hamishehkar H
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Mobasseri, Majid
AU  - Mobasseri M
AD  - Endocrinology Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Ebrahimzadeh, Vahide
AU  - Ebrahimzadeh V
AD  - Department of Nutrition, Maragheh University of Medical Sciences, Maragheh, Iran.
FAU - Alipour, Mahdiye
AU  - Alipour M
AD  - Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University 
      of Medical Sciences, Tabriz, Iran.
FAU - Alipour, Beitollah
AU  - Alipour B
AUID- ORCID: 0000-0003-3008-5490
AD  - Department of Community Nutrition, Faculty of Nutrition, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190403
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Oils)
SB  - IM
EIN - J Cell Physiol. 2020 Apr;235(4):4023. PMID: 31904129
MH  - Adult
MH  - Blood Glucose/drug effects
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy/genetics
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Glucose Transporter Type 4/*genetics
MH  - Glycated Hemoglobin/drug effects
MH  - Glycemic Index/drug effects
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage/chemistry
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*drug therapy/pathology
MH  - Plant Oils/administration & dosage/chemistry
MH  - Pomegranate/*chemistry
MH  - Seeds/chemistry
OTO - NOTNLM
OT  - diabetes mellitus
OT  - fasting blood glucose
OT  - glucose transporter type 4
OT  - glycated hemoglobin A
OT  - pomegranate seed oil
EDAT- 2019/04/05 06:00
MHDA- 2020/06/06 06:00
CRDT- 2019/04/05 06:00
PHST- 2018/12/23 00:00 [received]
PHST- 2019/03/04 00:00 [revised]
PHST- 2019/03/06 00:00 [accepted]
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2020/06/06 06:00 [medline]
PHST- 2019/04/05 06:00 [entrez]
AID - 10.1002/jcp.28561 [doi]
PST - ppublish
SO  - J Cell Physiol. 2019 Nov;234(11):19621-19628. doi: 10.1002/jcp.28561. Epub 2019 
      Apr 3.