PMID- 30945973
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 2164-554X (Electronic)
IS  - 2164-5515 (Print)
IS  - 2164-5515 (Linking)
VI  - 16
IP  - 2
DP  - 2020
TI  - Intravenous immunoglobulin suppresses the polarization of both classically and 
      alternatively activated macrophages.
PG  - 233-239
LID - 10.1080/21645515.2019.1602434 [doi]
AB  - Intravenous immunoglobulin (IVIG) is one of the widely used immunotherapeutic 
      molecules in the therapy of autoimmune and inflammatory diseases. Previous 
      reports demonstrate that one of the anti-inflammatory actions of IVIG implicates 
      suppression of macrophage activation and release of their inflammatory mediators. 
      However, macrophages are highly plastic and depending on the microenvironmental 
      signals, macrophages can be polarized into pro-inflammatory classic (M1) or 
      anti-inflammatory alternative (M2) type. This plasticity of macrophages raised 
      additional questions on the role of IVIG towards macrophage polarization. In the 
      present report, we show that IVIG affects the polarization of both classically 
      and alternatively activated macrophages and this process is 
      F(ab')(2)-independent. Our data thus indicate the lack of reciprocal regulation 
      of inflammatory and non-inflammatory macrophages by IVIG.
FAU - Saha, Chaitrali
AU  - Saha C
AUID- ORCID: 0000-0002-2769-0617
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Equipe-Immunopathologie et Immunointervention Therapeutique, 
      Sorbonne Universite, Universite Paris Descartes, Paris, France.
AD  - UMR CNRS 6022, Universite de Technologie de Compiegne, Compiegne, France.
FAU - Kothapalli, Prathap
AU  - Kothapalli P
AUID- ORCID: 0000-0002-6180-6134
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Equipe-Immunopathologie et Immunointervention Therapeutique, 
      Sorbonne Universite, Universite Paris Descartes, Paris, France.
FAU - Patil, Veerupaxagouda
AU  - Patil V
AUID- ORCID: 0000-0001-9849-7040
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Equipe-Immunopathologie et Immunointervention Therapeutique, 
      Sorbonne Universite, Universite Paris Descartes, Paris, France.
FAU - ManjunathaReddy, Gundallahalli Bayyappa
AU  - ManjunathaReddy GB
AUID- ORCID: 0000-0001-8578-7823
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Equipe-Immunopathologie et Immunointervention Therapeutique, 
      Sorbonne Universite, Universite Paris Descartes, Paris, France.
AD  - Department of Veterinary Pathology, ICAR-National Institute of Veterinary 
      Epidemiology and Disease Informatics, Bengaluru, India.
FAU - Kaveri, Srini V
AU  - Kaveri SV
AUID- ORCID: 0000-0002-0837-4053
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Equipe-Immunopathologie et Immunointervention Therapeutique, 
      Sorbonne Universite, Universite Paris Descartes, Paris, France.
FAU - Bayry, Jagadeesh
AU  - Bayry J
AUID- ORCID: 0000-0003-0498-9808
AD  - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche 
      des Cordeliers, Equipe-Immunopathologie et Immunointervention Therapeutique, 
      Sorbonne Universite, Universite Paris Descartes, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190507
PL  - United States
TA  - Hum Vaccin Immunother
JT  - Human vaccines & immunotherapeutics
JID - 101572652
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Anti-Inflammatory Agents
MH  - *Immunoglobulins, Intravenous
MH  - Macrophage Activation
MH  - *Macrophages
PMC - PMC7062444
OTO - NOTNLM
OT  - IVIG
OT  - IgG
OT  - inflammation
OT  - innate cells
OT  - macrophage
OT  - monocyte
EDAT- 2019/04/05 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/05/07
CRDT- 2019/04/05 06:00
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/04/05 06:00 [entrez]
PHST- 2020/05/07 00:00 [pmc-release]
AID - 1602434 [pii]
AID - 10.1080/21645515.2019.1602434 [doi]
PST - ppublish
SO  - Hum Vaccin Immunother. 2020;16(2):233-239. doi: 10.1080/21645515.2019.1602434. 
      Epub 2019 May 7.