PMID- 30946359
OWN - NLM
STAT- MEDLINE
DCOM- 20190412
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 14
DP  - 2019 Apr
TI  - Immune imbalance is associated with the development of preeclampsia.
PG  - e15080
LID - 10.1097/MD.0000000000015080 [doi]
LID - e15080
AB  - Preeclampsia (PE) is characterized by hypertension and proteinuria. It affects 
      about 5% to 8% of pregnancies and causes maternal and perinatal mortality and 
      morbidity. The immune imbalance and excessive inflammatory response play vital 
      roles in the pathogenesis of PE.In this study, we performed a case-control study 
      to investigate the levels of cytokines, chemokines and adhesion molecules in 
      serum and placenta of normal pregnant and PE women by Bio-Plex multiplex 
      immunoassay and immunohistochemistry. In addition, we explored the phenotypes of 
      monocyte and macrophage in peripheral blood and placentas in 2 groups by using 
      flow cytometry analysis and immunohistochemistry.Our results show that 
      pro-inflammatory factors, including interleukin-1beta (IL-1beta), IL-6, IL-7, IL-8, 
      IL-17a, monocyte chemotactic protein 1 (MCP -1), and macrophage inflammatory 
      protein 1beta (MIP-1beta) were significantly increased in serum of women with PE 
      compared with controls. In addition, we detected that IL-1beta, IL-6, and MCP-1 were 
      also increased in placentas of women with PE. We further revealed that peripheral 
      blood monocytes showed a pro-inflammatory M1-like phenotype in women with PE. 
      Consistently, M1 macrophage infiltration was increased in placenta of women with 
      PE compared to that of normal pregnant women.Our results demonstrated that immune 
      imbalance promotes an inflammatory state during PE and it may be a potential 
      therapeutic possibility for the management of PE.
FAU - Ma, Yu
AU  - Ma Y
AD  - State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of 
      Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute 
      of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Ye, Yao
AU  - Ye Y
AD  - Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, 
      Germany.
FAU - Zhang, Jin
AU  - Zhang J
AD  - State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of 
      Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute 
      of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Ruan, Cheng-Chao
AU  - Ruan CC
AD  - State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of 
      Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute 
      of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
AD  - Laboratory of Vascular Biology and Key Laboratory of Stem Cell Biology, Institute 
      of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy 
      of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Gao, Ping-Jin
AU  - Gao PJ
AD  - State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of 
      Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute 
      of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
AD  - Laboratory of Vascular Biology and Key Laboratory of Stem Cell Biology, Institute 
      of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy 
      of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukins)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cell Adhesion Molecules/blood
MH  - Chemokine CCL2/*blood
MH  - Chemokine CCL4/*blood/immunology
MH  - Female
MH  - Humans
MH  - Interleukin-1beta/blood
MH  - Interleukins/*blood/immunology
MH  - Placenta/immunology/*metabolism
MH  - Pre-Eclampsia/blood/*immunology
MH  - Pregnancy
MH  - Young Adult
PMC - PMC6455976
COIS- The authors declare no conflict of interest.
EDAT- 2019/04/05 06:00
MHDA- 2019/04/13 06:00
PMCR- 2019/04/05
CRDT- 2019/04/05 06:00
PHST- 2019/04/05 06:00 [entrez]
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2019/04/13 06:00 [medline]
PHST- 2019/04/05 00:00 [pmc-release]
AID - 00005792-201904050-00051 [pii]
AID - MD-D-18-03722 [pii]
AID - 10.1097/MD.0000000000015080 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Apr;98(14):e15080. doi: 10.1097/MD.0000000000015080.