PMID- 30946849
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20191217
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 126
DP  - 2019 Jun
TI  - Therapeutic strategy against ischemic stroke with the concept of neurovascular 
      unit.
PG  - 246-251
LID - S0197-0186(19)30043-9 [pii]
LID - 10.1016/j.neuint.2019.03.022 [doi]
AB  - Stroke is one of the leading causes of death and disability globally. Although 
      thrombolytic therapy by t-PA and mechanical thrombectomy have improved outcomes 
      of ischemic stroke patients, both of these approaches are applicable to limited 
      numbers of patients owing to their time constraints. Therefore, development of 
      other treatment approaches such as developing neuroprotective drugs and nerve 
      regeneration therapy is required to overcome ischemic stroke. The concept of the 
      neurovascular unit (NVU) was formalized by the Stroke Progress Review Group of 
      the National Institute of Neurological Disorders and Stroke in 2001. This concept 
      emphasizes the importance not just of neurons but of the interactions between 
      neurons, endothelial cells, astroglia, microglia and associated tissue matrix 
      proteins to investigate the pathological condition of ischemic stroke. Many 
      reports have been published about these interactions. This review focuses on the 
      roles of cells that surround cerebral vasculature, especially endothelial cells, 
      and reports therapeutic strategies against ischemic stroke from four points of 
      view including angiogenesis, neurotrophic effects, protection of NVU components 
      and regenerative therapy.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Ozaki, Tomohiko
AU  - Ozaki T
AD  - Department of Neurosurgery, Graduate School of Medicine, Osaka University, Japan; 
      Department of Molecular Neuroscience, Graduate School of Medicine, Osaka 
      University, Japan. Electronic address: tomohikoozaki@gmail.com.
FAU - Nakamura, Hajime
AU  - Nakamura H
AD  - Department of Neurosurgery, Graduate School of Medicine, Osaka University, Japan.
FAU - Kishima, Haruhiko
AU  - Kishima H
AD  - Department of Neurosurgery, Graduate School of Medicine, Osaka University, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190401
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/drug effects/*metabolism
MH  - Brain/drug effects/*metabolism
MH  - Brain Ischemia/*metabolism/therapy
MH  - Humans
MH  - Neovascularization, Pathologic/metabolism/therapy
MH  - Nerve Growth Factors/metabolism/therapeutic use
MH  - Neuroprotective Agents/*administration & dosage
MH  - Stroke/*metabolism/therapy
OTO - NOTNLM
OT  - Ischemic stroke
OT  - Neuron
OT  - Neurovascular unit
OT  - Vascular endothelial cell
EDAT- 2019/04/05 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/04/05 06:00
PHST- 2019/01/20 00:00 [received]
PHST- 2019/03/05 00:00 [revised]
PHST- 2019/03/28 00:00 [accepted]
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/04/05 06:00 [entrez]
AID - S0197-0186(19)30043-9 [pii]
AID - 10.1016/j.neuint.2019.03.022 [doi]
PST - ppublish
SO  - Neurochem Int. 2019 Jun;126:246-251. doi: 10.1016/j.neuint.2019.03.022. Epub 2019 
      Apr 1.