PMID- 30946928
OWN - NLM
STAT- MEDLINE
DCOM- 20200205
LR  - 20200621
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 704
DP  - 2019 Jun 21
TI  - Serotonergic system, cognition, and BPSD in Alzheimer's disease.
PG  - 36-44
LID - S0304-3940(19)30214-9 [pii]
LID - 10.1016/j.neulet.2019.03.050 [doi]
AB  - Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost 90% 
      of patients with Alzheimer's Disease (AD), cause extensive impairment leading to 
      reduced independence and inability to complete activities of daily living. Though 
      BPSD includes a wide range of symptoms, such as agitation, aggression, 
      disinhibition, anxiety, depression, apathy, delusions, and hallucinations. 
      Certain BPSD in AD co-present and can be clustered into distinct domains based on 
      their frequency of co-occurrence. As these BPSD are so pervasive in any stages of 
      AD, the disease may be better characterized as a disorder of heterogeneous 
      degenerative symptoms across a number of symptom domains, with the most prominent 
      domain comprising memory and cognitive deficits. Importantly, there are no 
      FDA-approved drugs to treat these BPSD, and new approaches must be considered to 
      develop effective treatments for AD patients. The biogenic monoamine 
      5-hydroxytryptamine (5-HT), or serotonin, works as both a neurotransmitter and 
      neuromodulator, which has been tied to cognitive decline and multiple BPSD 
      domains. This review summarizes the evidence for specific serotonergic system 
      alterations across some of the well-studied cognitive, behavioral, and 
      psychiatric domains. Though differences in overall serotonergic transmission 
      occur in AD, circuit-specific alterations in individual 5-HT receptors (5-HTRs) 
      are likely linked to the heterogeneous presentation of BPSD in AD.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Chakraborty, Saikat
AU  - Chakraborty S
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA.
FAU - Lennon, Jack C
AU  - Lennon JC
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA.
FAU - Malkaram, Sridhar A
AU  - Malkaram SA
AD  - Department of Biology, West Virginia State University Institute, WV-25112, USA.
FAU - Zeng, Yan
AU  - Zeng Y
AD  - Brain and Cognition Research Institute, Wuhan University of Science and 
      Technology, China.
FAU - Fisher, Daniel W
AU  - Fisher DW
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA.
FAU - Dong, Hongxin
AU  - Dong H
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA. 
      Electronic address: h-dong@northwestern.edu.
LA  - eng
GR  - R01 AG062249/AG/NIA NIH HHS/United States
GR  - R01 MH109466/MH/NIMH NIH HHS/United States
GR  - R21 MH100919/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20190401
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Receptors, Serotonin)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Alzheimer Disease/*metabolism/*psychology
MH  - Animals
MH  - *Cognition
MH  - Humans
MH  - Memory
MH  - Mood Disorders/metabolism/psychology
MH  - Psychotic Disorders/metabolism/psychology
MH  - Receptors, Serotonin/genetics/metabolism
MH  - Serotonin/*metabolism
PMC - PMC6594906
MID - NIHMS1526491
OTO - NOTNLM
OT  - 5-HT receptors (5-HTRs)
OT  - 5-hydroxytryptamine (5-HT)
OT  - Alzheimer's disease
OT  - Behavioral and psychological symptoms of dementia (BPSD)
EDAT- 2019/04/05 06:00
MHDA- 2020/02/06 06:00
PMCR- 2020/06/21
CRDT- 2019/04/05 06:00
PHST- 2018/11/15 00:00 [received]
PHST- 2019/03/26 00:00 [revised]
PHST- 2019/03/27 00:00 [accepted]
PHST- 2019/04/05 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/04/05 06:00 [entrez]
PHST- 2020/06/21 00:00 [pmc-release]
AID - S0304-3940(19)30214-9 [pii]
AID - 10.1016/j.neulet.2019.03.050 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Jun 21;704:36-44. doi: 10.1016/j.neulet.2019.03.050. Epub 
      2019 Apr 1.