PMID- 30947511
OWN - NLM
STAT- MEDLINE
DCOM- 20200107
LR  - 20200107
IS  - 1941-3084 (Electronic)
IS  - 1941-3084 (Linking)
VI  - 12
IP  - 4
DP  - 2019 Apr
TI  - Simultaneous Comparison of Electrocardiographic Imaging and Epicardial Contact 
      Mapping in Structural Heart Disease.
PG  - e007120
LID - 10.1161/CIRCEP.118.007120 [doi]
AB  - BACKGROUND: The accuracy of ECG imaging (ECGI) in structural heart disease 
      remains uncertain. This study aimed to provide a detailed comparison of ECGI and 
      contact-mapping system (CARTO) electrograms. METHODS: Simultaneous epicardial 
      mapping using CARTO (Biosense-Webster, CA) and ECGI (CardioInsight) in 8 patients 
      was performed to compare electrogram morphology, activation time (AT), and 
      repolarization time (RT). Agreement between AT and RT from CARTO and ECGI was 
      assessed using Pearson correlation coefficient, rho (AT) and rho (RT), root mean 
      square error, E (AT) and E (RT), and Bland-Altman plots. RESULTS: After geometric 
      coregistration, 711 (439-905; median, first-third quartiles) ECGI and CARTO 
      points were paired per patient. AT maps showed rho (AT)=0.66 (0.53-0.73) and E 
      (AT)=24 (21-32) ms, RT maps showed rho (RT)=0.55 (0.41-0.71) and E (RT)=51 (38-70) 
      ms. The median correlation coefficient measuring the morphological similarity 
      between the unipolar electrograms was equal to 0.71 (0.65-0.74) for the entire 
      signal, 0.67 (0.59-0.76) for QRS complexes, and 0.57 (0.35-0.76) for T waves. 
      Local activation map correlation, rho (AT), was lower when default filters were 
      used (0.60 (0.30-0.71), P=0.053). Small misalignment of the ECGI and CARTO 
      geometries (below +/-4 mm and +/-4 degrees ) could introduce variations in the median rho (AT) 
      up to +/-25%. Minimum distance between epicardial pacing sites and the region of 
      earliest activation in ECGI was 13.2 (0.0-28.3) mm from 25 pacing sites with 
      stimulation to QRS interval <40 ms. CONCLUSIONS: This simultaneous assessment 
      demonstrates that ECGI maps activation and repolarization parameters with 
      moderate accuracy. ECGI and contact electrogram correlation is sensitive to 
      electrode apposition and geometric alignment. Further technological developments 
      may improve spatial resolution.
FAU - Graham, Adam J
AU  - Graham AJ
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Orini, Michele
AU  - Orini M
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
AD  - Department of Mechanical Engineering (M.O.), University College London, United 
      Kingdom.
FAU - Zacur, Ernesto
AU  - Zacur E
AD  - Institute of Biomedical Engineering, University of Oxford, United Kingdom (E.Z.).
FAU - Dhillon, Gurpreet
AU  - Dhillon G
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Daw, Holly
AU  - Daw H
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Srinivasan, Niel T
AU  - Srinivasan NT
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Lane, Jem D
AU  - Lane JD
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Cambridge, Alex
AU  - Cambridge A
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Garcia, Jason
AU  - Garcia J
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - O'Reilly, Nanci J
AU  - O'Reilly NJ
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Whittaker-Axon, Sarah
AU  - Whittaker-Axon S
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Taggart, Peter
AU  - Taggart P
AD  - Institute of Cardiovascular Science (P.T., P.D.L.), University College London, 
      United Kingdom.
FAU - Lowe, Martin
AU  - Lowe M
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Finlay, Malcolm
AU  - Finlay M
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Earley, Mark J
AU  - Earley MJ
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Chow, Antony
AU  - Chow A
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Sporton, Simon
AU  - Sporton S
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Dhinoja, Mehul
AU  - Dhinoja M
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Schilling, Richard J
AU  - Schilling RJ
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Hunter, Ross J
AU  - Hunter RJ
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
FAU - Lambiase, Pier D
AU  - Lambiase PD
AD  - Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., 
      G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., 
      M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).
AD  - Institute of Cardiovascular Science (P.T., P.D.L.), University College London, 
      United Kingdom.
LA  - eng
GR  - PG/16/81/32441/BHF_/British Heart Foundation/United Kingdom
GR  - DH_/Department of Health/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circ Arrhythm Electrophysiol
JT  - Circulation. Arrhythmia and electrophysiology
JID - 101474365
SB  - IM
MH  - Catheter Ablation
MH  - *Electrocardiography
MH  - *Epicardial Mapping
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tachycardia, Ventricular/*physiopathology/surgery
OTO - NOTNLM
OT  - ECG imaging
OT  - activation and repolarization maps
OT  - contact mapping
OT  - unipolar electrograms
OT  - ventricular tachycardia
EDAT- 2019/04/06 06:00
MHDA- 2020/01/08 06:00
CRDT- 2019/04/06 06:00
PHST- 2019/04/06 06:00 [entrez]
PHST- 2019/04/06 06:00 [pubmed]
PHST- 2020/01/08 06:00 [medline]
AID - 10.1161/CIRCEP.118.007120 [doi]
PST - ppublish
SO  - Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007120. doi: 
      10.1161/CIRCEP.118.007120.