PMID- 30949597
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 5
IP  - 3
DP  - 2019 Mar
TI  - Autobiographical memories, identity disturbance and brain functioning in patients 
      with borderline personality disorder: An fMRI study.
PG  - e01323
LID - 10.1016/j.heliyon.2019.e01323 [doi]
LID - e01323
AB  - Identity disturbance is a core feature of borderline personality disorder (BPD). 
      Autobiographical memory is a process of reflective thinking through which we form 
      links between elements of life and self. It can be considered as an indirect 
      index of identity integration. The present study was aimed to investigate the 
      differences in brain activity patterns between BPD patients with identity 
      diffusion and healthy controls using fMRI. We enrolled 24 BPD patients and 24 
      healthy controls. Identity integration in patients and controls was assessed with 
      the Identity Disturbance Questionnaire (IDQ) score and was significantly 
      different (p = 0.001). We analysed hemodynamic response in the regions of 
      interest during presentation of resolved and unresolved life events. With 
      reference to the condition "resolved", increased cerebral activity in right 
      anterior cingulate cortex (ACC), right medial prefrontal cortex (MPFC), right 
      dorsolateral prefrontal cortex (DLPFC), and bilateral insula was registered in 
      BPD patients compared with controls. In the condition "unresolved", increased 
      brain activity was observed in patients in bilateral ACC, bilateral DLPFC, and 
      right temporo-parietal junction. Hyperactivity in ACC and DLPFC in BPD patients 
      with both conditions (resolved and unresolved contexts) may be due to an 
      inefficient attempt to reconstruct a coherent narrative of life events (resolved 
      or not).
FAU - Bozzatello, Paola
AU  - Bozzatello P
AD  - Centre for Personality Disorders, Department of Neuroscience, University of 
      Turin, Turin, Italy.
FAU - Morese, Rosalba
AU  - Morese R
AD  - Department of Psychology, University of Turin, Italy.
AD  - Faculty of Communication Sciences, Universita della Svizzera Italiana, Lugano, 
      Switzerland.
FAU - Valentini, Maria Consuelo
AU  - Valentini MC
AD  - Department of Neuroradiology, Hospital/Citta della Salute e della Scienza, Turin 
      Italy.
FAU - Rocca, Paola
AU  - Rocca P
AD  - Department of Neuroscience, University of Turin, Turin, Italy.
AD  - Neuroscience Institute of Turin, Italy.
FAU - Bosco, Francesca
AU  - Bosco F
AD  - Department of Psychology, University of Turin, Italy.
AD  - Neuroscience Institute of Turin, Italy.
FAU - Bellino, Silvio
AU  - Bellino S
AD  - Centre for Personality Disorders, Department of Neuroscience, University of 
      Turin, Turin, Italy.
AD  - Neuroscience Institute of Turin, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190319
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC6430005
OTO - NOTNLM
OT  - Neuroscience
OT  - Psychiatry
EDAT- 2019/04/06 06:00
MHDA- 2019/04/06 06:01
PMCR- 2019/03/19
CRDT- 2019/04/06 06:00
PHST- 2018/08/24 00:00 [received]
PHST- 2019/01/21 00:00 [revised]
PHST- 2019/03/04 00:00 [accepted]
PHST- 2019/04/06 06:00 [entrez]
PHST- 2019/04/06 06:00 [pubmed]
PHST- 2019/04/06 06:01 [medline]
PHST- 2019/03/19 00:00 [pmc-release]
AID - S2405-8440(18)35057-6 [pii]
AID - e01323 [pii]
AID - 10.1016/j.heliyon.2019.e01323 [doi]
PST - epublish
SO  - Heliyon. 2019 Mar 19;5(3):e01323. doi: 10.1016/j.heliyon.2019.e01323. eCollection 
      2019 Mar.