PMID- 30949941
OWN - NLM
STAT- MEDLINE
DCOM- 20190702
LR  - 20200225
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 26
IP  - 15
DP  - 2019 May
TI  - The relationship of maternal PCB, toxic, and essential trace element exposure 
      levels with birth weight and head circumference in Chiba, Japan.
PG  - 15677-15684
LID - 10.1007/s11356-019-05009-0 [doi]
AB  - Maternal exposure to high levels of persistent organic pollutants (POPs) and 
      trace elements is an important concern for fetal growth. In our previous study, 
      we showed the polychlorinated biphenyl (PCB) levels in maternal serum from the 
      Chiba Study of Mother and Child Health (C-MACH) cohort and their relationships 
      between PCB levels in cord serum with birth weight of newborn. Various reports on 
      the relationship between chemical exposure and birth status have been published; 
      however, studies that analyze the effects of both PCB and metal exposure together 
      in one cohort are still limited. In this study, we aimed to determine the 
      relationship of maternal serum levels of PCBs and toxic and essential trace 
      elements [mercury (Hg), manganese (Mn), selenium (Se), and cadmium (Cd)], with 
      birth weight and head circumference, in the C-MACH cohort. The median 
      concentration of total PCBs in maternal serum around 32 gestational weeks 
      (n = 62) was 360 pg g(-1) wet wt (41 ng g(-1) lipid wt). The levels of Hg, Mn, 
      Se, and Cd in maternal serum were 0.89, 0.84, 100, and 0.024 ng g(-1), 
      respectively. In this study, the Bayesian linear model determined the 
      relationships of the birth weight and head circumference with combinations of PCB 
      levels, toxic and essential trace elements, and questionnaire data. We found that 
      PCB concentrations in maternal serum were weakly and negatively related to birth 
      weight, whereas trace elements were not associated with birth weight. Serum PCB 
      and Mn levels were negatively associated with head circumference, whereas other 
      trace elements were not associated with head circumference. These results showed 
      that maternal exposure to PCBs may be related to birth weight and head 
      circumference, while maternal exposure to Mn is related to head circumference, 
      even when adjusted based on the exposure levels of other contaminants, and 
      maternal and fetal characteristics. Therefore, our findings indicate that 
      maternal exposure to PCBs and Mn might be negatively related with birth weight 
      and head circumference.
FAU - Eguchi, Akifumi
AU  - Eguchi A
AD  - Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 
      1-33, Chiba, Japan.
FAU - Yanase, Kana
AU  - Yanase K
AD  - Chiba Foundation for Health Promotion and Disease Prevention, Mihama-ku 
      Shin-Minato 32-14, Chiba, Japan.
AD  - Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba 
      University, Chuo-ku Inohana 1-8-1, Chiba, 260-8670, Japan.
FAU - Yamamoto, Midori
AU  - Yamamoto M
AD  - Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 
      1-33, Chiba, Japan.
FAU - Sakurai, Kenichi
AU  - Sakurai K
AD  - Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 
      1-33, Chiba, Japan.
FAU - Watanabe, Masahiro
AU  - Watanabe M
AD  - Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 
      1-33, Chiba, Japan.
FAU - Todaka, Emiko
AU  - Todaka E
AD  - Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 
      1-33, Chiba, Japan.
AD  - Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba 
      University, Chuo-ku Inohana 1-8-1, Chiba, 260-8670, Japan.
FAU - Mori, Chisato
AU  - Mori C
AD  - Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 
      1-33, Chiba, Japan. cmori@faculty.chiba-u.jp.
AD  - Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba 
      University, Chuo-ku Inohana 1-8-1, Chiba, 260-8670, Japan. 
      cmori@faculty.chiba-u.jp.
LA  - eng
GR  - 16H01781/Japan Society for the Promotion of Science/
GR  - 18K18199/Japan Society for the Promotion of Science/
GR  - 5-1652/Ministry of the Environment/
PT  - Journal Article
DEP - 20190404
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Environmental Pollutants)
RN  - 0 (Trace Elements)
RN  - 00BH33GNGH (Cadmium)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Bayes Theorem
MH  - Birth Weight/*drug effects
MH  - Cadmium/*analysis/chemistry
MH  - Cohort Studies
MH  - Environmental Pollutants/*analysis/chemistry
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Japan
MH  - Maternal Exposure/*statistics & numerical data
MH  - Polychlorinated Biphenyls/*analysis/chemistry
MH  - Selenium/*analysis/chemistry
MH  - Trace Elements/*analysis/chemistry
OTO - NOTNLM
OT  - Birth cohort
OT  - Fetal growth
OT  - Polychlorinated biphenyls
OT  - Toxic and essential elements
EDAT- 2019/04/06 06:00
MHDA- 2019/07/03 06:00
CRDT- 2019/04/06 06:00
PHST- 2018/12/12 00:00 [received]
PHST- 2019/03/26 00:00 [accepted]
PHST- 2019/04/06 06:00 [pubmed]
PHST- 2019/07/03 06:00 [medline]
PHST- 2019/04/06 06:00 [entrez]
AID - 10.1007/s11356-019-05009-0 [pii]
AID - 10.1007/s11356-019-05009-0 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2019 May;26(15):15677-15684. doi: 
      10.1007/s11356-019-05009-0. Epub 2019 Apr 4.