PMID- 30950656 OWN - NLM STAT- MEDLINE DCOM- 20200610 LR - 20200610 IS - 1473-4877 (Electronic) IS - 0300-7995 (Linking) VI - 35 IP - 9 DP - 2019 Sep TI - Relationship of obesity to adverse events in myocardial infarction patients without primary percutaneous coronary intervention: results from the Occluded Artery Trial (OAT). PG - 1563-1569 LID - 10.1080/03007995.2019.1603993 [doi] AB - Objective: Our goal was to investigate the "obesity paradox" in myocardial infarction populations without primary percutaneous coronary intervention (PPCI).Methods: The Occluded Artery Trial (OAT, Clinicaltrials.gov: NCT00004562) is a randomized, multicenter study to investigate the influence of routine percutaneous coronary intervention (PCI) on the clinical outcomes of myocardial infarction patients without PPCI. We stratified these patients into three groups according to body mass index (BMI): normal, 18.5 kg/m(2) /= 30 kg/m(2). The purpose of our study was to investigate the effects of BMI on the primary endpoint (all-cause mortality) and the secondary endpoint (cardiac death, non-cardiac death or New York Heart Association [NYHA] class IV heart failure) in the population enrolled in the OAT.Results: A total of 2153 patients (99.4%) constituted the final study population. We found that obese patients were younger and were more likely to have cardiovascular risk factors compared with other BMI groups. A U-shaped relationship was observed between BMI and all-cause mortality. The adjusted hazard ratios (HRs) were 0.892 (95% CI: 0.658-1.210, p = .460) for normal weight patients and 0.671 (95% CI: 0.508-0.888, p = .013) for overweight patients compared with obese patients. The same pattern was also observed for non-cardiac death. The adjusted HRs were 0.919 (95% CI: 0.601-1.40, p = .663) for normal weight patients and 0.524 (95% CI: 0.346-0.792, p = .004) for overweight patients compared with obese patients. We did not find any statistical differences among BMI categories in terms of cardiac death or NYHA class IV heart failure.Conclusions: A U-shaped relationship was observed between BMI and all-cause mortality or non-cardiac death. Overweight patients have the lowest risk of all-cause mortality, which may be attributed to their having the lowest risk of non-cardiac death of the groups studied. FAU - Xing, Zhenhua AU - Xing Z AD - Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China. FAU - Pei, Junyu AU - Pei J AD - Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China. FAU - Huang, Jiabing AU - Huang J AD - Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China. FAU - Hu, Xinqun AU - Hu X AD - Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China. FAU - Gao, Shan AU - Gao S AD - Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China. LA - eng SI - ClinicalTrials.gov/NCT00004562 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20190510 PL - England TA - Curr Med Res Opin JT - Current medical research and opinion JID - 0351014 SB - IM MH - Aged MH - Body Mass Index MH - Female MH - Humans MH - Male MH - Middle Aged MH - Myocardial Infarction/*complications/mortality/therapy MH - Obesity/*complications MH - Overweight/complications MH - *Percutaneous Coronary Intervention MH - Retrospective Studies OTO - NOTNLM OT - Obesity paradox OT - all-cause mortality OT - myocardial infarction OT - primary percutaneous coronary intervention EDAT- 2019/04/06 06:00 MHDA- 2020/06/11 06:00 CRDT- 2019/04/06 06:00 PHST- 2019/04/06 06:00 [pubmed] PHST- 2020/06/11 06:00 [medline] PHST- 2019/04/06 06:00 [entrez] AID - 10.1080/03007995.2019.1603993 [doi] PST - ppublish SO - Curr Med Res Opin. 2019 Sep;35(9):1563-1569. doi: 10.1080/03007995.2019.1603993. Epub 2019 May 10.