PMID- 30951217
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1472-8206 (Electronic)
IS  - 0767-3981 (Linking)
VI  - 33
IP  - 6
DP  - 2019 Dec
TI  - Felbamate produces antidepressant-like actions in the chronic unpredictable mild 
      stress and chronic social defeat stress models of depression.
PG  - 621-633
LID - 10.1111/fcp.12466 [doi]
AB  - Felbamate is an anticonvulsant used in the treatment of epilepsy. In this study, 
      we investigated the antidepressant-like actions of felbamate in mice. The effects 
      of felbamate were first assessed using the forced swimming test (FST) and tail 
      suspension test (TST), and then investigated in the chronic unpredictable mild 
      stress (CUMS) and chronic social defeat stress (CSDS) models of depression. The 
      changes in the hippocampal brain-derived neurotrophic factor (BDNF) signaling 
      cascade after chronic stress and felbamate treatment were also examined. It was 
      found that felbamate exhibited antidepressant-like activities in the FST and TST 
      without affecting the locomotor activity of mice. Felbamate was also effective in 
      both the CUMS and CSDS models of depression. Moreover, felbamate administration 
      fully restored the decreased hippocampal BDNF signaling pathway in both the 
      CUMS-stressed and CSDS-stressed mice. Collectively, felbamate has 
      antidepressant-like actions in mice involving the hippocampal BDNF system.
CI  - (c) 2019 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Li, Xiuqin
AU  - Li X
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Nantong University, Taizhou, 225300, Jiangsu Province, China.
FAU - Wang, Hongze
AU  - Wang H
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Nantong University, Taizhou, 225300, Jiangsu Province, China.
FAU - Chen, Qingnian
AU  - Chen Q
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Nantong University, Taizhou, 225300, Jiangsu Province, China.
FAU - Li, Zhiqin
AU  - Li Z
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Nantong University, Taizhou, 225300, Jiangsu Province, China.
FAU - Liu, Chao
AU  - Liu C
AD  - Yangtze River Pharmaceutical Group, Taizhou, 225321, Jiangsu Province, China.
FAU - Yin, Shengnan
AU  - Yin S
AD  - Department of Pharmacy, Taizhou Hospital of Traditional Chinese Medicine, 
      Taizhou, 225300, Jiangsu Province, China.
FAU - You, Zhengchen
AU  - You Z
AUID- ORCID: 0000-0001-8589-811X
AD  - Department of Burns and Plastic Surgery, Taizhou People's Hospital, The Fifth 
      Affiliated Hospital of Nantong University, Taizhou, 225300, Jiangsu Province, 
      China.
LA  - eng
GR  - TS201732/Taizhou Science and Technology Support Plan (Social Development) 
      Project/
PT  - Journal Article
DEP - 20190424
PL  - England
TA  - Fundam Clin Pharmacol
JT  - Fundamental & clinical pharmacology
JID - 8710411
RN  - 0 (Antidepressive Agents)
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - X72RBB02N8 (Felbamate)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/physiology
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Felbamate/*pharmacology
MH  - Hindlimb Suspension
MH  - Hippocampus/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Receptors, N-Methyl-D-Aspartate/drug effects
MH  - Stress, Psychological/drug therapy
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - chronic social defeat stress
OT  - chronic unpredictable mild stress
OT  - depression
OT  - felbamate
EDAT- 2019/04/06 06:00
MHDA- 2020/04/14 06:00
CRDT- 2019/04/06 06:00
PHST- 2019/01/02 00:00 [received]
PHST- 2019/03/04 00:00 [revised]
PHST- 2019/04/03 00:00 [accepted]
PHST- 2019/04/06 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/04/06 06:00 [entrez]
AID - 10.1111/fcp.12466 [doi]
PST - ppublish
SO  - Fundam Clin Pharmacol. 2019 Dec;33(6):621-633. doi: 10.1111/fcp.12466. Epub 2019 
      Apr 24.