PMID- 30951224
OWN - NLM
STAT- MEDLINE
DCOM- 20200220
LR  - 20200220
IS  - 1098-1101 (Electronic)
IS  - 0733-2459 (Linking)
VI  - 34
IP  - 5
DP  - 2019 Oct
TI  - Adverse events during apheresis: A 10-year experience at a tertiary academic 
      medical center.
PG  - 528-536
LID - 10.1002/jca.21706 [doi]
AB  - BACKGROUND: Apheresis can be associated with adverse events (AEs). Available 
      studies published on apheresis-associated AEs lack uniformity of data. 
      Unfortunately, there is no common database in the United States (US) to report 
      apheresis-associated AEs. We evaluated our institutional incidence of 
      apheresis-associated AEs and compared it with published literature. STUDY DESIGN 
      AND METHODS: We conducted a 10-year retrospective study of apheresis procedures 
      and associated AEs at our facility, a tertiary academic medical center, from 2007 
      to 2016. Concurrently, a literature search was conducted on AEs associated with 
      apheresis procedures. Twenty-eight studies including data from US and other 
      countries' facilities were analyzed. RESULTS: The overall AE incidence was 6.9% 
      (396/5684 procedures). Frequency of AEs associated with therapeutic plasma 
      exchange (TPE) was higher (8.5%, P < .0001) compared to other apheresis 
      procedures. Significant correlation between number of TPE and AEs (Spearman rho 
      [r(s) ] = 0.7, P = .002) was encountered. Furthermore, there was a significant 
      decrease over time of moderate and severe AEs (r(s)  = -0.64, P = .04 and r(s) 
       = -0.83, P = .003 respectively). Comparison of our institutional AEs (6.9%) to 
      data from other countries (9.8%) and US (22.6%) indicated a significant 
      difference (P < .0001). CONCLUSION: Overall our incidence of AEs was 
      significantly lower than current published literature. Incidence of AEs published 
      in other countries is significantly lower than US rates. Differences in incidence 
      of AEs emphasize need for uniform reporting and stratification of AEs and 
      development of a common database to report AEs. Therefore, we propose a grading 
      rationale in order to standardize reporting of AEs.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Kundrapu, Sirisha
AU  - Kundrapu S
AUID- ORCID: 0000-0002-3779-4823
AD  - Department of Pathology, University Hospitals Cleveland Medical Center, 
      Cleveland, Ohio.
AD  - Department of Pathology, Division of Transfusion Medicine, Case Western Reserve 
      University School of Medicine, Cleveland, OH.
FAU - Datla, Sireesha
AU  - Datla S
AD  - Department of Pathology, University Hospitals Cleveland Medical Center, 
      Cleveland, Ohio.
FAU - Griffin, Vanessa
AU  - Griffin V
AD  - Department of Pathology, University Hospitals Cleveland Medical Center, 
      Cleveland, Ohio.
FAU - Maitta, Robert W
AU  - Maitta RW
AUID- ORCID: 0000-0002-5424-5519
AD  - Department of Pathology, University Hospitals Cleveland Medical Center, 
      Cleveland, Ohio.
AD  - Department of Pathology, Division of Transfusion Medicine, Case Western Reserve 
      University School of Medicine, Cleveland, OH.
LA  - eng
GR  - Office of Diversity and Inclusion of the University Hospitals Cleveland Medical 
      Center/
PT  - Journal Article
PT  - Multicenter Study
DEP - 20190405
PL  - United States
TA  - J Clin Apher
JT  - Journal of clinical apheresis
JID - 8216305
SB  - IM
MH  - Academic Medical Centers
MH  - Blood Component Removal/*adverse effects
MH  - Databases, Factual/*standards
MH  - Global Health
MH  - Humans
MH  - Incidence
MH  - Plasma Exchange/adverse effects
MH  - Retrospective Studies
MH  - Tertiary Care Centers
MH  - United States
OTO - NOTNLM
OT  - adverse events
OT  - apheresis
OT  - complications
OT  - hematopoietic stem cell collection
OT  - red cell exchange
OT  - therapeutic plasma exchange
EDAT- 2019/04/06 06:00
MHDA- 2020/02/23 06:00
CRDT- 2019/04/06 06:00
PHST- 2018/08/14 00:00 [received]
PHST- 2019/03/21 00:00 [accepted]
PHST- 2019/04/06 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
PHST- 2019/04/06 06:00 [entrez]
AID - 10.1002/jca.21706 [doi]
PST - ppublish
SO  - J Clin Apher. 2019 Oct;34(5):528-536. doi: 10.1002/jca.21706. Epub 2019 Apr 5.