PMID- 30951617
OWN - NLM
STAT- MEDLINE
DCOM- 20191119
LR  - 20191119
IS  - 2300-9020 (Electronic)
IS  - 1644-387X (Linking)
VI  - 56
IP  - 1
DP  - 2019 Jan-Mar
TI  - Does metabolic control affect salivary adipokines in type 2 diabetes mellitus?
PG  - 11-20
LID - 10.17219/dmp/103417 [doi]
AB  - BACKGROUND: Adipokines produced by adipose tissue initiate pro-inflammatory 
      events and contribute to the pathogenesis of diabetic periodontitis. OBJECTIVES: 
      The aim of this study was to evaluate the effect of the metabolic status on the 
      level of salivary adipokines in type 2 diabetes mellitus (T2DM) patients. 
      MATERIAL AND METHODS: A total of 239 individuals, including 161 T2DM patients and 
      78 healthy (H) controls, participated in the study. The metabolic control status 
      was evaluated in each person. Periodontal measurements were recorded. Periodontal 
      epithelial surface area (PESA), periodontal inflamed surface area (PISA) and the 
      total dental index (TDI) were calculated. The salivary adiponectin, tumor 
      necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and vaspin levels were 
      determined. RESULTS: The T2DM patients had higher periodontal parameters and 
      adiponectin, TNF-alpha, IL-6, and vaspin levels as compared with the H controls (p < 
      0.05). As the metabolic control worsened, periodontal pocket depth (PPD) and 
      clinical attachment level (CAL) increased. When covariates (age, gender, body 
      mass index - BMI, education level, smoking, dental visit and tooth brushing 
      frequency) were adjusted, only the TNF-alpha and vaspin levels were significantly 
      higher in the T2DM patients (p < 0.05). In the T2DM patients, positive 
      correlations were found between the TNF-alpha level and the percentage of bleeding on 
      probing (BOP%), PPD, PESA, and PISA, and between the adiponectin level and PISA. 
      Moreover, there was a negative relationship between the salivary volume and TDI. 
      While the correlations IL-6-TNF-alpha, vaspin-triglycerides and vaspin-tooth brushing 
      frequency were positive, the statistically significant associations vaspin-IL-6 
      and vaspin-low-density lipoprotein (LDL) were negative (p < 0.05). CONCLUSIONS: 
      The severity of periodontal disease increases as the metabolic control status 
      worsens. The levels of salivary adipokines were changed by T2DM, while being 
      independent from the metabolic control.
FAU - Teke, Elif
AU  - Teke E
AD  - Department of Periodontology, Faculty of Dentistry, Suleyman Demirel University, 
      Isparta, Turkey.
FAU - Kirzioglu, Fatma Yesim
AU  - Kirzioglu FY
AD  - Department of Periodontology, Faculty of Dentistry, Suleyman Demirel University, 
      Isparta, Turkey.
FAU - Korkmaz, Hakan
AU  - Korkmaz H
AD  - Department of Internal Medicine, Faculty of Medicine, Suleyman Demirel 
      University, Isparta, Turkey.
FAU - Calapoglu, Mustafa
AU  - Calapoglu M
AD  - Department of Biochemistry, Faculty of Arts and Sciences, Suleyman Demirel 
      University, Isparta, Turkey.
FAU - Orhan, Hikmet
AU  - Orhan H
AD  - Department of Biostatistics and Medical Informatics, Faculty of Medicine, 
      Suleyman Demirel University, Isparta, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Dent Med Probl
JT  - Dental and medical problems
JID - 101205669
RN  - 0 (Adipokines)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - *Adipokines/metabolism
MH  - Adult
MH  - *Diabetes Mellitus, Type 2/complications/metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Periodontal Pocket/metabolism
MH  - *Periodontitis/etiology/metabolism
MH  - *Saliva/metabolism
OTO - NOTNLM
OT  - adipokines
OT  - diabetes mellitus type 2
OT  - periodontal disease
OT  - saliva
OT  - vaspin
EDAT- 2019/04/06 06:00
MHDA- 2019/11/20 06:00
CRDT- 2019/04/06 06:00
PHST- 2019/04/06 06:00 [entrez]
PHST- 2019/04/06 06:00 [pubmed]
PHST- 2019/11/20 06:00 [medline]
AID - 10.17219/dmp/103417 [doi]
PST - ppublish
SO  - Dent Med Probl. 2019 Jan-Mar;56(1):11-20. doi: 10.17219/dmp/103417.