PMID- 30951957
OWN - NLM
STAT- MEDLINE
DCOM- 20191223
LR  - 20191223
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 173
DP  - 2019 Jun
TI  - The impact on T-regulatory cell related immune responses in rural women exposed 
      to polycyclic aromatic hydrocarbons (PAHs) in household air pollution in Gansu, 
      China: A pilot investigation.
PG  - 306-317
LID - S0013-9351(19)30181-1 [pii]
LID - 10.1016/j.envres.2019.03.053 [doi]
AB  - Previous studies found associations between impairments of immune functions and 
      exposure to polycyclic aromatic hydrocarbons (PAHs) in ambient air pollution in 
      the U. S. and China. However, the results remain inconclusive due to the 
      limitations of these studies. In this study, we aimed to examine the direction 
      and magnitude of immune changes related to PAH exposure from household air 
      pollution among rural women living in Gansu, China. Healthy village women 
      (n = 34) were recruited and enrolled in the study. Questionnaires were 
      administered. Blood and urine samples were collected and analyzed during 
      non-heating (September 2017, "summer") and heating (January 2018, "winter") 
      seasons. Urinary 1-hydroxypyrene (1-OHP) was quantified as the biomarker of PAH 
      exposure. To evaluate Treg cell related immune functions, we examined 
      immunoglobulin E (IgE), percent of T-regulatory (Treg) cells, and gene expression 
      of following: forkhead box transcription factor 3 (Foxp3), transforming growth 
      factor-beta (TGF-beta), interleukin 10 (IL-10), and interleukin 35 (IL-35), composed of 
      interleukin-12 alpha (IL-12alpha) and Epstein-Barr-virus-induced gene 3 (EBi3). 
      Urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) was measured to evaluate oxidative 
      DNA damage. The results showed that the concentration of 1-OHP increased from 
      0.90 to 17.4 mumol mol-Cr (-1) from summer to winter (p < 0.001). Meanwhile, 
      average percent of Treg cells decreased from 5.01% to 1.15% (p < 0.001); IgE and 
      mRNA expressions of Foxp3, TGF-beta, IL-10, IL-12alpha and EBi3 all significantly 
      decreased (p < 0.001); Urinary 8-OHdG increased from 12.7 to 30.3 ng mg-Cr (-1) 
      (p < 0.001). The changes in 8-OHdG, Foxp3 and TGF-beta were significantly associated 
      with the increase of 1-OHP. The results suggested that we observed a substantial 
      increase of PAH exposure in winter, which was significantly associated with the 
      repression on Treg cell function and oxidative DNA damage. Exposure to PAHs in 
      household air pollution possibly induced immune impairments among rural women in 
      northwest China.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Yao, Yueli
AU  - Yao Y
AD  - Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, 
      Gansu, China.
FAU - Wang, Dong
AU  - Wang D
AD  - Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, 
      Gansu, China.
FAU - Ma, Haitao
AU  - Ma H
AD  - Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, 
      Gansu, China.
FAU - Li, Chengyun
AU  - Li C
AD  - Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, 
      Gansu, China.
FAU - Chang, Xiaoru
AU  - Chang X
AD  - Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, Jiangsu, China.
FAU - Low, Patrick
AU  - Low P
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      California, Berkeley, CA, USA.
FAU - Hammond, S Katharine
AU  - Hammond SK
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      California, Berkeley, CA, USA.
FAU - Turyk, Mary Ellen
AU  - Turyk ME
AD  - School of Public Health, University of Illinois, Chicago, IL, USA.
FAU - Wang, Junling
AU  - Wang J
AD  - Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, 
      Gansu, China. Electronic address: wangjl@lzu.edu.cn.
FAU - Liu, Sa
AU  - Liu S
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      California, Berkeley, CA, USA; School of Health Sciences, College of Health and 
      Human Sciences, Purdue University, West Lafayette, IN, USA. Electronic address: 
      saliu@purdue.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190326
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Pyrenes)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Air Pollution
MH  - Air Pollution, Indoor/*statistics & numerical data
MH  - China
MH  - Deoxyguanosine
MH  - Environmental Exposure/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Immunity/*drug effects
MH  - Pilot Projects
MH  - Polycyclic Aromatic Hydrocarbons/*toxicity
MH  - Pyrenes
MH  - T-Lymphocytes, Regulatory
OTO - NOTNLM
OT  - 1-OHP
OT  - 8-OHdG
OT  - Cytokines
OT  - Household air pollution
OT  - Immune system
OT  - Treg cell
EDAT- 2019/04/06 06:00
MHDA- 2019/12/24 06:00
CRDT- 2019/04/06 06:00
PHST- 2018/11/05 00:00 [received]
PHST- 2019/02/16 00:00 [revised]
PHST- 2019/03/21 00:00 [accepted]
PHST- 2019/04/06 06:00 [pubmed]
PHST- 2019/12/24 06:00 [medline]
PHST- 2019/04/06 06:00 [entrez]
AID - S0013-9351(19)30181-1 [pii]
AID - 10.1016/j.envres.2019.03.053 [doi]
PST - ppublish
SO  - Environ Res. 2019 Jun;173:306-317. doi: 10.1016/j.envres.2019.03.053. Epub 2019 
      Mar 26.