PMID- 30952712
OWN - NLM
STAT- MEDLINE
DCOM- 20190423
LR  - 20190423
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 39
IP  - 4
DP  - 2019 Apr
TI  - Adipose-specific Monocyte Chemotactic Protein-1 Deficiency Reduces Pulmonary 
      Metastasis of Lewis Lung Carcinoma in Mice.
PG  - 1729-1738
LID - 10.21873/anticanres.13279 [doi]
AB  - AIM: Monocyte chemotactic protein-1 (MCP1) is a potent adipokine. This study 
      tested the hypothesis that adipose-produced MCP1 contributes to metastasis. 
      MATERIALS AND METHODS: In a spontaneous metastasis model of Lewis lung carcinoma 
      (LLC), male adipose MCP1-deficient (Mcp1(-/-)) and wild-type (WT) mice were fed 
      the AIN93G diet or a high-fat diet (HFD) for 11 weeks. Lung metastasis from a 
      subcutaneous tumor was the primary endpoint. RESULTS: The adipose expression of 
      MCP1 was lower in Mcp1(-/-) mice than in WT controls. The HFD increased the 
      number of lung metastases in WT mice. The number of metastasis was significantly 
      lower in the HFD-fed Mcp1(-/-) mice than in the HFD-fed WT mice. Compared to the 
      WT mice, adipose MCP1 deficiency lowered plasma concentrations of insulin, 
      proinflammatory adipokines (leptin, plasminogen activator inhibitor-1, and 
      resistin), and angiogenic markers (vascular endothelial growth factor, hepatocyte 
      growth factor, and angiopoietin-2). CONCLUSION: Adipose MCP1 deficiency 
      attenuates HFD-enhanced pulmonary metastasis of LLC.
CI  - Copyright(c) 2019, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Sundaram, Sneha
AU  - Sundaram S
AD  - U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human 
      Nutrition Research Center, Grand Forks, ND, U.S.A.
FAU - Yan, Lin
AU  - Yan L
AD  - U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human 
      Nutrition Research Center, Grand Forks, ND, U.S.A. lin.yan@ars.usda.gov.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Adipokines)
RN  - 0 (Angiogenic Proteins)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adipokines/metabolism
MH  - Adipose Tissue/*metabolism
MH  - Adiposity
MH  - Angiogenic Proteins/metabolism
MH  - Animals
MH  - Carcinoma, Lewis Lung/genetics/*metabolism/prevention & control/*secondary
MH  - Chemokine CCL2/*deficiency/genetics
MH  - Diet, High-Fat
MH  - Inflammation Mediators/metabolism
MH  - Lung Neoplasms/genetics/*metabolism/prevention & control/*secondary
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neoplasm Invasiveness
MH  - Signal Transduction
OTO - NOTNLM
OT  - Lewis lung carcinoma
OT  - MCP1
OT  - adiposity
OT  - diet
OT  - metastasis
OT  - mouse model
EDAT- 2019/04/07 06:00
MHDA- 2019/04/24 06:00
CRDT- 2019/04/07 06:00
PHST- 2019/02/09 00:00 [received]
PHST- 2019/03/04 00:00 [revised]
PHST- 2019/03/07 00:00 [accepted]
PHST- 2019/04/07 06:00 [entrez]
PHST- 2019/04/07 06:00 [pubmed]
PHST- 2019/04/24 06:00 [medline]
AID - 39/4/1729 [pii]
AID - 10.21873/anticanres.13279 [doi]
PST - ppublish
SO  - Anticancer Res. 2019 Apr;39(4):1729-1738. doi: 10.21873/anticanres.13279.