PMID- 30953871
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 153
DP  - 2019 Jul
TI  - Infection with HHV-6 and its role in epilepsy.
PG  - 34-39
LID - S0920-1211(18)30622-3 [pii]
LID - 10.1016/j.eplepsyres.2019.03.016 [doi]
AB  - Infection with Human Herpesvirus-6 (HHV-6) has been associated with different 
      epilepsy syndromes, including febrile seizures and status epilepticus, acute 
      symptomatic seizures secondary to encephalitis and temporal lobe epilepsy. This 
      neurotropic DNA virus is ubiquitous and primary infection occurs in up to 80% of 
      children by age two years. While two viral variants have been identified, HHV-6B 
      is the one that has been primarily linked to disease in humans, including 
      epilepsy. After initial viremia, the virus can establish chronic latency in brain 
      tissue, peripherally in tonsils and salivary glands and infect several different 
      cell lines by binding to the complement regulator CD-46. In this review we will 
      focus on discussing the evidence linking HHV-6 infection to different epilepsy 
      syndromes and analyzing proposed pathogenic mechanisms.
CI  - Published by Elsevier B.V.
FAU - Bartolini, Luca
AU  - Bartolini L
AD  - Clinical Epilepsy Section, National Institute of Neurological Disorders and 
      Stroke, NIH, 10 Center Drive, Bethesda, MD 20892, USA; Division of 
      Neuroimmunology and Neurovirology, National Institute of Neurological Disorders 
      and Stroke, NIH, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: 
      luca.bartolini@nih.gov.
FAU - Theodore, William H
AU  - Theodore WH
AD  - Clinical Epilepsy Section, National Institute of Neurological Disorders and 
      Stroke, NIH, 10 Center Drive, Bethesda, MD 20892, USA.
FAU - Jacobson, Steven
AU  - Jacobson S
AD  - Division of Neuroimmunology and Neurovirology, National Institute of Neurological 
      Disorders and Stroke, NIH, 10 Center Drive, Bethesda, MD 20892, USA.
FAU - Gaillard, William D
AU  - Gaillard WD
AD  - Center for Neuroscience, Children's National Medical Center, George Washington 
      University, 111 Michigan Ave NW, Washington, DC 20010, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20190329
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
SB  - IM
MH  - Epilepsy/*complications/*virology
MH  - Herpesvirus 6, Human/genetics/*pathogenicity
MH  - Humans
MH  - Roseolovirus Infections/*complications/virology
OTO - NOTNLM
OT  - Children
OT  - Epilepsy
OT  - Febrile seizures
OT  - HHV-6
OT  - Seizures
OT  - Temporal lobe epilepsy
EDAT- 2019/04/07 06:00
MHDA- 2019/09/04 06:00
CRDT- 2019/04/07 06:00
PHST- 2019/01/02 00:00 [received]
PHST- 2019/03/18 00:00 [revised]
PHST- 2019/03/24 00:00 [accepted]
PHST- 2019/04/07 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2019/04/07 06:00 [entrez]
AID - S0920-1211(18)30622-3 [pii]
AID - 10.1016/j.eplepsyres.2019.03.016 [doi]
PST - ppublish
SO  - Epilepsy Res. 2019 Jul;153:34-39. doi: 10.1016/j.eplepsyres.2019.03.016. Epub 
      2019 Mar 29.