PMID- 30954084
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20200225
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 18
IP  - 1
DP  - 2019 Apr 6
TI  - Prevalence of dyslipidemia associated with complications in diabetic patients: a 
      nationwide study in Thailand.
PG  - 90
LID - 10.1186/s12944-019-1034-3 [doi]
LID - 90
AB  - BACKGROUND: Dyslipidemia is an important modifiable risk factor for 
      cardiovascular disease. It is diagnosed by the presence of an abnormal lipid 
      profile, primarily with elevated levels of plasma cholesterol, triglyceride, or 
      both, or reduced levels of high-density lipoprotein cholesterol. However, some 
      studies have reported increased risk of ischemic stroke with elevated low-density 
      lipoprotein cholesterol (LDL-C) levels and increased risk of cardiovascular 
      mortality independent of LDL-C levels in type 2 diabetes mellitus (T2DM) 
      patients. METHODS: In this cross-sectional study, data were included for Thai 
      adults with diabetes from the Diabetes Mellitus/ Hypertension (DM/HT) study, 
      2010-2014 (data was collected by the Medical Research Network of the Consortium 
      of Thai Medical Schools). The target population comprised T2DM patients who were 
      treated at a hospital for more than 12 months. Adjusted odds ratios (aORs) and 
      95% confidence intervals (CIs) were calculated to determine factors associated 
      with dyslipidemia. RESULTS: In total, 140,557 participants (average age, 
      60 years) were enrolled, with a dyslipidemia prevalence of 88.9% in the cohort. 
      The factors associated with dyslipidemia included female sex (aOR: 1.47, 95% CI: 
      1.38-1.56); age < 50 years (aOR: 1.16, 95% CI: 1.10-1.22); waist 
      circumference >/= 90 cm in males and >/= 80 cm in females (aOR: 1.23, 95% CI: 
      1.16-1.31); treatment at a primary care unit (aOR: 1.28, 95% CI: 1.23-1.33); and 
      a history of unknown stroke (aOR: 1.10, 95% CI: 1.02-1.19), coronary 
      revascularization (aOR: 0.85, 95% CI: 0.79-0.91), diabetic nephropathy (aOR: 
      1.06, 95% CI: 1.01-1.12), or renal insufficiency (aOR: 1.08, 95% CI: 1.02-1.13). 
      CONCLUSIONS: Dyslipidemia is prevalent among Thai T2DMpatients and is associated 
      with gender; age; obesity; central obesity; treatment at a primary care unit; and 
      a history of unknown stroke, coronary revascularization, diabetic nephropathy, 
      and renal insufficiency. Our study results will help increase the awareness of 
      healthcare providers regarding dyslipidemia in diabetic patients. To reduce 
      cardiovascular risk, healthcare professionals should provide regular follow-up 
      and proper advice and ensure primary prevention of vascular complications. 
      Improved education and increased self-awareness regarding the need to change 
      behaviors and regular intake of medication would help decrease dyslipidemia 
      prevalence among diabetic patients.
FAU - Narindrarangkura, Ploypun
AU  - Narindrarangkura P
AUID- ORCID: 0000-0001-5737-2559
AD  - Department of Military and Community Medicine, Phramongkutklao College of 
      Medicine, 315 Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand. 
      ploypun.n@hotmail.com.
FAU - Bosl, William
AU  - Bosl W
AD  - Health Informatics Program, School of Nursing and Health Professions of the 
      University of San Francisco, 2130 Fulton St, San Francisco, CA, 94117, USA.
FAU - Rangsin, Ram
AU  - Rangsin R
AD  - Department of Military and Community Medicine, Phramongkutklao College of 
      Medicine, 315 Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand.
FAU - Hatthachote, Panadda
AU  - Hatthachote P
AD  - Department of Physiology, Phramongkutklao College of Medicine, 315 Ratchawithi 
      Road, Ratchathewi, Bangkok, 10400, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20190406
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
MH  - Adult
MH  - Aged
MH  - Cholesterol/blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus, Type 2/blood/complications/*epidemiology
MH  - Diabetic Nephropathies/blood/*epidemiology/etiology
MH  - Dyslipidemias/blood/complications/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/blood/epidemiology/etiology
MH  - Percutaneous Coronary Intervention
MH  - Renal Insufficiency/blood/*epidemiology/etiology
MH  - Risk Factors
MH  - Rural Population
MH  - Thailand/epidemiology
MH  - Triglycerides/blood
PMC - PMC6451778
OTO - NOTNLM
OT  - Complications
OT  - Diabetes
OT  - Dyslipidemia
OT  - Prevalence
OT  - T2DM
OT  - Thailand
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was reviewed and approved 
      by the Institutional Review Board of Royal Thai Army Medical Department 
      (S058 h/60_Exp). CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: 
      The authors declare that they have no competing interests. PUBLISHER'S NOTE: 
      Springer Nature remains neutral with regard to jurisdictional claims in published 
      maps and institutional affiliations.
EDAT- 2019/04/08 06:00
MHDA- 2019/07/30 06:00
PMCR- 2019/04/06
CRDT- 2019/04/08 06:00
PHST- 2018/05/28 00:00 [received]
PHST- 2019/03/28 00:00 [accepted]
PHST- 2019/04/08 06:00 [entrez]
PHST- 2019/04/08 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2019/04/06 00:00 [pmc-release]
AID - 10.1186/s12944-019-1034-3 [pii]
AID - 1034 [pii]
AID - 10.1186/s12944-019-1034-3 [doi]
PST - epublish
SO  - Lipids Health Dis. 2019 Apr 6;18(1):90. doi: 10.1186/s12944-019-1034-3.