PMID- 30954207
OWN - NLM
STAT- MEDLINE
DCOM- 20200129
LR  - 20200129
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 123
IP  - 11
DP  - 2019 Jun 1
TI  - Relation Between New York Heart Association Functional Class and Objective 
      Measures of Cardiopulmonary Exercise in Adults With Congenital Heart Disease.
PG  - 1868-1873
LID - S0002-9149(19)30299-1 [pii]
LID - 10.1016/j.amjcard.2019.02.053 [doi]
AB  - We aimed to compare New York Heart Association (NYHA) functional class in adult 
      congenital heart disease (ACHD) patients with objectively measured 
      cardiopulmonary exercise testing (CPET) parameters. This study included 
      retrospective review of ACHD patients who underwent a CPET between August 2014 
      and April 2018 at our center. Patients were grouped according to severity of CHD, 
      and NYHA class as recorded in their medical record or estimated from the clinical 
      narrative. A total of 175 ACHD patients (mean age 30 +/- 11 years) with NYHA class 
      I-III enrolled in the study. The NYHA functional class was II or III in most 
      complex CHD. There was a strong inverse relation between NYHA class and peak 
      oxygen consumption, oxygen uptake efficiency slope, and the double product at 
      peak exercise (product of heart rate and systolic blood pressure) (p<0.0001). 
      There was no relation between NYHA class and ventilation efficiency slope 
      (p = 0.37). In conclusion, NYHA functional class correlates with objective 
      measures of CPET, however there is wide variability in measured exercise capacity 
      in each NYHA classification. Therefore, whereas NYHA class of patients is a 
      simple measure for assessment of functional status, CPET is an important tool to 
      identify the source of exercise limitation in ACHD patients.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Das, Bibhuti B
AU  - Das BB
AD  - Joe DiMaggio Children's Hospital Heart Institute, Memorial Healthcare System, 
      Hollywood, Florida. Electronic address: bdas@mhs.net.
FAU - Young, Ming-Lon
AU  - Young ML
AD  - Joe DiMaggio Children's Hospital Heart Institute, Memorial Healthcare System, 
      Hollywood, Florida.
FAU - Niu, Jianli
AU  - Niu J
AD  - Office of Human Research, Memorial Healthcare System, Hollywood, Florida.
FAU - Mendoza, Laura E
AU  - Mendoza LE
AD  - Office of Human Research, Memorial Healthcare System, Hollywood, Florida.
FAU - Chan, Kak-Chen
AU  - Chan KC
AD  - Joe DiMaggio Children's Hospital Heart Institute, Memorial Healthcare System, 
      Hollywood, Florida; Adult Congenital Heart Center, Memorial Healthcare System, 
      Hollywood, Florida.
FAU - Roth, Todd
AU  - Roth T
AD  - Adult Congenital Heart Center, Memorial Healthcare System, Hollywood, Florida.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190315
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Adult
MH  - *Exercise Test
MH  - Female
MH  - Heart Defects, Congenital/classification/*physiopathology
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2019/04/08 06:00
MHDA- 2020/01/30 06:00
CRDT- 2019/04/08 06:00
PHST- 2019/01/08 00:00 [received]
PHST- 2019/02/21 00:00 [revised]
PHST- 2019/02/26 00:00 [accepted]
PHST- 2019/04/08 06:00 [pubmed]
PHST- 2020/01/30 06:00 [medline]
PHST- 2019/04/08 06:00 [entrez]
AID - S0002-9149(19)30299-1 [pii]
AID - 10.1016/j.amjcard.2019.02.053 [doi]
PST - ppublish
SO  - Am J Cardiol. 2019 Jun 1;123(11):1868-1873. doi: 10.1016/j.amjcard.2019.02.053. 
      Epub 2019 Mar 15.