PMID- 30954629
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20200323
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 144
DP  - 2019 Jun
TI  - Complex regulation of ecto-5'-nucleotidase/CD73 and A(2A)R-mediated adenosine 
      signaling at neurovascular unit: A link between acute and chronic 
      neuroinflammation.
PG  - 99-115
LID - S1043-6618(18)31909-1 [pii]
LID - 10.1016/j.phrs.2019.04.007 [doi]
AB  - The review summarizes available data regarding the complex regulation of CD73 at 
      the neurovascular unit (NVU) during neuroinflammation. Based on available data we 
      propose the biphasic pattern of CD73 regulation at NVU, with an early attenuation 
      and a postponed up-regulation of CD73 activity. Transient attenuation of CD73 
      activity on leukocyte/vascular endothelium and leukocyte/astrocyte surface, 
      required for the initiation of a neuroinflammatory response, may be effectuated 
      either by catalytic inhibition of CD73 and/or by shedding of the CD73 molecule 
      from the cell surface, while postponed induction of CD73 is effectuated by 
      transcriptional up-regulation of Nt5e and posttranslational modifications. 
      Neuroinflammatory conditions are also associated with significant enhancement and 
      gain-of-function of A(2A)R-mediated adenosine signaling. However, in contrast to 
      the temporary prevalence of A(2A)R over A(1)R signaling during an acute 
      inflammatory response, prolonged induction of A(2A)R and resulting perpetual 
      CD73/A(2A)R coupling may be a contributing factors in the transition between 
      acute and chronic neuroinflammation. Thus, pharmacological targeting of the 
      CD73/A(2A)R axis may attenuate inflammatory response and ameliorate neurological 
      deficits in chronic neuroinflammatory conditions.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Nedeljkovic, Nadezda
AU  - Nedeljkovic N
AD  - Department of General Physiology and Biophysics, Faculty of Biology University of 
      Belgrade, Studentski trg 3, Belgrade 11001, Serbia. Electronic address: 
      nnedel@bio.bg.ac.rs.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190405
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Receptor, Adenosine A2A)
RN  - EC 3.1.3.5 (5'-Nucleotidase)
RN  - EC 3.1.3.5 (NT5E protein, human)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - 5'-Nucleotidase/*immunology
MH  - Adenosine/*immunology
MH  - Animals
MH  - Chronic Disease
MH  - GPI-Linked Proteins/immunology
MH  - Humans
MH  - Inflammation/*immunology
MH  - Nervous System Diseases/immunology
MH  - *Neurovascular Coupling
MH  - Receptor, Adenosine A2A/*immunology
MH  - Signal Transduction
OTO - NOTNLM
OT  - A(1)R
OT  - A(2A)R
OT  - Adenosine
OT  - Astrocytes
OT  - Chronic neuroinflammation
OT  - Ecto-5'-nucleotidase/CD73
EDAT- 2019/04/08 06:00
MHDA- 2020/03/24 06:00
CRDT- 2019/04/08 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/04/01 00:00 [revised]
PHST- 2019/04/03 00:00 [accepted]
PHST- 2019/04/08 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2019/04/08 06:00 [entrez]
AID - S1043-6618(18)31909-1 [pii]
AID - 10.1016/j.phrs.2019.04.007 [doi]
PST - ppublish
SO  - Pharmacol Res. 2019 Jun;144:99-115. doi: 10.1016/j.phrs.2019.04.007. Epub 2019 
      Apr 5.