PMID- 30954706
OWN - NLM
STAT- MEDLINE
DCOM- 20200131
LR  - 20200131
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 197
DP  - 2019 Aug 15
TI  - The brain-derived neurotrophic factor Val66Met genotype does not influence the 
      grey or white matter structures underlying recognition memory.
PG  - 1-12
LID - S1053-8119(19)30278-2 [pii]
LID - 10.1016/j.neuroimage.2019.03.072 [doi]
AB  - A single nucleotide polymorphism (SNP) in the gene coding for brain-derived 
      neurotrophic factor (BDNF) has previously been associated with a reduction in 
      recognition memory performance. While previous findings have highlighted that 
      this SNP contributes to recognition memory, little is known about its influence 
      on subprocesses of recognition, familiarity and recollection. Previous research 
      has reported reduced hippocampal volume and decreased fractional anisotropy in 
      carriers of the Met allele across a range of white matter tracts, including those 
      networks that may support recognition memory. Here, in a sample of 61 healthy 
      young adults, we used a source memory task to measure accuracy on each 
      recognition subprocess, in order to determine whether the Val66Met SNP (rs6265) 
      influences these equally. Additionally, we compared grey matter volume between 
      these groups for structures that underpin familiarity and recollection 
      separately. Finally, we used probabilistic tractography to reconstruct tracts 
      that subserve each of these two recognition systems. Behaviourally, we found 
      group differences on the familiarity measure, but not on recollection. However, 
      we did not find any group difference on grey- or white-matter structures. 
      Together, these results suggest a functional influence of the Val66Met SNP that 
      is independent of coarse structural changes, and nuance previous research 
      highlighting the relationship between BDNF, brain structure, and behaviour.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - McKay, Nicole S
AU  - McKay NS
AD  - School of Psychology, University of Auckland, New Zealand. Electronic address: 
      nicole.mckay@auckland.ac.nz.
FAU - Moreau, David
AU  - Moreau D
AD  - School of Psychology, University of Auckland, New Zealand.
FAU - Henare, Dion T
AU  - Henare DT
AD  - School of Psychology, University of Auckland, New Zealand.
FAU - Kirk, Ian J
AU  - Kirk IJ
AD  - School of Psychology, University of Auckland, New Zealand; Brain Research New 
      Zealand, New Zealand.
LA  - eng
PT  - Journal Article
DEP - 20190404
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/anatomy & histology/*physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Genotype
MH  - Gray Matter/anatomy & histology/*physiology
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Recognition, Psychology/*physiology
MH  - White Matter/anatomy & histology/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Diffusion tensor imaging
OT  - Dual-process
OT  - Neurotrophic factor
OT  - Source memory
OT  - Structural magnetic resonance imaging
OT  - rs6265
EDAT- 2019/04/08 06:00
MHDA- 2020/02/01 06:00
CRDT- 2019/04/08 06:00
PHST- 2018/11/05 00:00 [received]
PHST- 2019/03/01 00:00 [revised]
PHST- 2019/03/30 00:00 [accepted]
PHST- 2019/04/08 06:00 [pubmed]
PHST- 2020/02/01 06:00 [medline]
PHST- 2019/04/08 06:00 [entrez]
AID - S1053-8119(19)30278-2 [pii]
AID - 10.1016/j.neuroimage.2019.03.072 [doi]
PST - ppublish
SO  - Neuroimage. 2019 Aug 15;197:1-12. doi: 10.1016/j.neuroimage.2019.03.072. Epub 
      2019 Apr 4.