PMID- 30956269
OWN - NLM
STAT- MEDLINE
DCOM- 20190830
LR  - 20190830
IS  - 1881-7823 (Electronic)
IS  - 1881-7815 (Linking)
VI  - 13
IP  - 2
DP  - 2019 May 12
TI  - Predictive value of some pro-oxidants in type 2 diabetes mellitus with vascular 
      complications.
PG  - 168-175
LID - 10.5582/bst.2019.01020 [doi]
AB  - The study aims to analyze oxidative stress levels in circulation of some reactive 
      molecules and products of biomolecular modification in type 2 diabetes mellitus 
      (T2DM) with diabetes-specific vascular complications in order to determine their 
      predictive value. Also, the alterations of their serum concentration with 
      reference to disease characteristics were assessed. Reactive oxygen species 
      (ROS), nitric oxide radicals (*NO), malondialdehyde (MDA), protein carbonyl (CO) 
      and 8-hydroxydeoxyguanosin (8-OHdG) in serum were measured in 93 patients with 
      T2DM with vascular complications, 94 control subjects and 16 diabetic patients 
      who had no evidence of vascular disease. T2DM patients with clinically manifest 
      vascular disease exhibit significantly elevated concentrations of all 
      pro-oxidants in comparison to healthy subjects, with the highest degree of 
      increase of *NO radicals. The levels of carbonylated proteins, ROS and 8-OHdG 
      were significantly increased in insufficiently compensated diabetes as compared 
      to good glycemic control state. Also, serum MDA, protein CO and 8-OHdG showed an 
      association with glycemic control parameters. MDA, ROS and 8-OHdG correlated 
      mostly with microvascular complications. Significant area under the curve (AUC) 
      from plotted receiver operating characteristic (ROC) curves were obtained for all 
      studied biomarkers, as for nitric oxide it was substantially bigger compared to 
      those for the other pro-oxidants. Correspondingly, positive and negative 
      predictive values related to the disease were in favor of the *NO radicals. The 
      cutoff values of oxidative biomarkers may serve as an indicator of clinical 
      reference for detecting T2DM with associated vascular complications, as nitric 
      oxide radicals were the most reliable indicator.
FAU - Goycheva, Petia
AU  - Goycheva P
AD  - Clinic of Endocrinology, University Hospital "Prof. Dr. Stoyan Kirkovich", 
      Medical Faculty, Trakia University.
FAU - Nikolova, Galina
AU  - Nikolova G
AD  - Department of Chemistry and Biochemistry, Medical Faculty, Trakia University.
FAU - Ivanova, Mariana
AU  - Ivanova M
AD  - Clinic of Rheumatology, University Hospital "St. Ivan Rilski", Medical Faculty, 
      Medical University.
FAU - Kundurdzhiev, Todor
AU  - Kundurdzhiev T
AD  - Faculty of Public Health, Medical University.
FAU - Gadjeva, Veselina
AU  - Gadjeva V
AD  - Department of Chemistry and Biochemistry, Medical Faculty, Trakia University.
LA  - eng
PT  - Journal Article
DEP - 20190408
PL  - Japan
TA  - Biosci Trends
JT  - Bioscience trends
JID - 101502754
RN  - 0 (Biomarkers)
RN  - 0 (Oxidants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Angiopathies/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidants/*blood
MH  - Predictive Value of Tests
MH  - ROC Curve
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - diabetes-specific vascular complications
OT  - oxidative stress
OT  - pro-oxidants
EDAT- 2019/04/09 06:00
MHDA- 2019/08/31 06:00
CRDT- 2019/04/09 06:00
PHST- 2019/04/09 06:00 [pubmed]
PHST- 2019/08/31 06:00 [medline]
PHST- 2019/04/09 06:00 [entrez]
AID - 10.5582/bst.2019.01020 [doi]
PST - ppublish
SO  - Biosci Trends. 2019 May 12;13(2):168-175. doi: 10.5582/bst.2019.01020. Epub 2019 
      Apr 8.