PMID- 30956976
OWN - NLM
STAT- MEDLINE
DCOM- 20190722
LR  - 20211204
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor-alpha 
      Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of 
      Chronic Stress.
PG  - 2649281
LID - 10.1155/2019/2649281 [doi]
LID - 2649281
AB  - Centella asiatica ameliorates memory impairment and induces expression of 
      hippocampal brain-derived neurotropic factor (BDNF) in chronically stressed rats. 
      The relationship between the anti-inflammatory effect of Centella asiatica on 
      hippocampal BDNF and the involvement of sirtuin-1, a BDNF expression regulator, 
      in neuroprotective mechanisms of Centella asiatica warrants an investigation. We 
      investigated the effect of Centella asiatica ethanolic extracts (CA) on TNF-alpha, 
      IL-10, and SIRT1 levels and whether these predicted BDNF expression in rat 
      hippocampus after chronic stress. For the experiments, thirty male rats (Sprague 
      Dawley) were divided into six groups: nonstressed-control, stressed-control, 
      nonstressed +CA 300mg/kg/d, stressed +CA 150 mg/kg/d, stressed +CA 300 mg/kg/d, 
      and stressed +CA 600 mg/kg/d. On day 28, rats were sacrificed and hippocampus was 
      dissected out. Hippocampal TNF-alpha, IL-10, SIRT1, and BDNF were measured by 
      enzyme-linked immunosorbent assay. Hippocampal TNF-alpha level was significantly 
      higher in the stressed-control compared to nonstressed-control groups. Across all 
      stress conditions, rats receiving the highest dose of CA had the lowest mean 
      TNF-alpha and highest mean BDNF. There were no significant differences in IL-10 and 
      SIRT1 levels between groups. Hippocampal TNF-alpha did not predict hippocampal BDNF 
      in a regression analysis. In conclusion, lower TNF-alpha and higher BDNF in the 
      hippocampus support the hypothesis that these factors independently contribute to 
      Centella asiatica's neuroprotective effect in chronically stressed rats.
FAU - Ar Rochmah, Mawaddah
AU  - Ar Rochmah M
AUID- ORCID: 0000-0003-2750-4615
AD  - Department of Anatomy, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
AD  - Department of Neurology, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
FAU - Harini, Ika Murti
AU  - Harini IM
AUID- ORCID: 0000-0002-4465-7878
AD  - Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and 
      Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
AD  - Department of Histology, Faculty of Medicine, Universitas Jenderal Soedirman, 
      Purwokerto, Central Java 53112, Indonesia.
FAU - Septyaningtrias, Dian Eurike
AU  - Septyaningtrias DE
AUID- ORCID: 0000-0001-9392-5480
AD  - Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and 
      Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
FAU - Sari, Dwi Cahyani Ratna
AU  - Sari DCR
AUID- ORCID: 0000-0002-1126-4939
AD  - Department of Anatomy, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
FAU - Susilowati, Rina
AU  - Susilowati R
AUID- ORCID: 0000-0001-8248-5803
AD  - Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and 
      Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20190306
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Centella asiatica extract)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Triterpenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Centella/*chemistry
MH  - Chronic Disease
MH  - Hippocampus/*metabolism/pathology
MH  - Male
MH  - Neuroprotective Agents/chemistry/*pharmacology
MH  - Plant Extracts
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Stress, Psychological/metabolism/pathology/prevention & control
MH  - Triterpenes/chemistry/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*metabolism
PMC - PMC6431365
EDAT- 2019/04/09 06:00
MHDA- 2019/07/23 06:00
PMCR- 2019/03/06
CRDT- 2019/04/09 06:00
PHST- 2018/09/20 00:00 [received]
PHST- 2019/02/13 00:00 [accepted]
PHST- 2019/04/09 06:00 [entrez]
PHST- 2019/04/09 06:00 [pubmed]
PHST- 2019/07/23 06:00 [medline]
PHST- 2019/03/06 00:00 [pmc-release]
AID - 10.1155/2019/2649281 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Mar 6;2019:2649281. doi: 10.1155/2019/2649281. eCollection 
      2019.