PMID- 30957184
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20200225
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 19
IP  - 6
DP  - 2019 Jun
TI  - Zinc finger E‑box binding homeobox 2 functions as an oncogene in human laryngeal 
      squamous cell carcinoma.
PG  - 4545-4552
LID - 10.3892/mmr.2019.10126 [doi]
AB  - Zinc finger E‑box binding homeobox 2 (ZEB2) is a member of the Zfh1 family of 
      two‑handed zinc finger/homeodomain proteins. To date, the role of ZEB2 in human 
      laryngeal carcinoma has not been clearly defined. In the present study, the level 
      of ZEB2 expression in laryngeal squamous cell carcinoma (LSCC) tissues and 
      adjacent normal tissues was evaluated using reverse transcription‑quantitative 
      polymerase chain reaction. The effects of ZEB2 on the growth, migration, 
      invasion, cell cycle distribution and apoptosis of laryngeal cancer cells were 
      also explored using MTT, Transwell and flow cytometry assays. It was identified 
      that ZEB2 was upregulated in LSCC tissues compared with normal tissues. Silencing 
      of ZEB2 inhibited the viability, migration and invasion of LSCC cells. It was 
      also observed that ZEB2 silencing induced cell cycle arrest and apoptosis in LSCC 
      cells. Furthermore, ZEB2 silencing inhibited the process of 
      epithelial‑mesenchymal transition. Overall, the results indicated that ZEB2 
      promotes the progression of LSCC and that it may be a potential target for the 
      treatment of this type of cancer.
FAU - Li, Qun
AU  - Li Q
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Lihuili Hospital of 
      Ningbo University, Ningbo, Zhejiang 315040, P.R. China.
FAU - Ma, Liang
AU  - Ma L
AD  - Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, 
      Zhejiang 315211, P.R. China.
FAU - Wu, Zhenhua
AU  - Wu Z
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center, 
      Lihuili Eastern Hospital, Ningbo, Zhejiang 315030, P.R. China.
FAU - Wang, Guoli
AU  - Wang G
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Lihuili Hospital of 
      Ningbo University, Ningbo, Zhejiang 315040, P.R. China.
FAU - Huang, Qi
AU  - Huang Q
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center, 
      Lihuili Eastern Hospital, Ningbo, Zhejiang 315030, P.R. China.
FAU - Shen, Zhisen
AU  - Shen Z
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Lihuili Hospital of 
      Ningbo University, Ningbo, Zhejiang 315040, P.R. China.
FAU - Yu, Rui
AU  - Yu R
AD  - Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, 
      Zhejiang 315211, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190404
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Cadherins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (ZEB2 protein, human)
RN  - 0 (Zinc Finger E-box Binding Homeobox 2)
MH  - Apoptosis
MH  - Cadherins/genetics/metabolism
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cell Cycle
MH  - Cell Cycle Checkpoints
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Epithelial-Mesenchymal Transition
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - *Oncogenes
MH  - Polymerase Chain Reaction
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Zinc Finger E-box Binding Homeobox 2/*genetics/metabolism
PMC - PMC6522803
EDAT- 2019/04/09 06:00
MHDA- 2019/08/27 06:00
PMCR- 2019/04/04
CRDT- 2019/04/09 06:00
PHST- 2017/09/24 00:00 [received]
PHST- 2018/12/04 00:00 [accepted]
PHST- 2019/04/09 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
PHST- 2019/04/09 06:00 [entrez]
PHST- 2019/04/04 00:00 [pmc-release]
AID - mmr-19-06-4545 [pii]
AID - 10.3892/mmr.2019.10126 [doi]
PST - ppublish
SO  - Mol Med Rep. 2019 Jun;19(6):4545-4552. doi: 10.3892/mmr.2019.10126. Epub 2019 Apr 
      4.