PMID- 30957249
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 46
IP  - 7
DP  - 2019 Jul
TI  - Cutaneous mantle cell lymphoma histomorphologically mimicking subcutaneous 
      panniculitis-like T-cell lymphoma: Case report.
PG  - 538-541
LID - 10.1111/cup.13471 [doi]
AB  - Secondary cutaneous involvement by mantle cell lymphoma (MCL), an uncommon 
      aggressive B-cell malignancy, predominantly involves the dermis, with few reports 
      of pannicular involvement. Lymphocytic infiltration of subcutaneous tissue is 
      associated with inflammatory panniculitides and certain T-cell lymphomas, 
      primarily subcutaneous panniculitis-like T-Cell lymphoma (SPTCL), which is 
      characterized by rimming of adipocytes by tumor cells. We report the case of a 
      69-year-old man with a history of systemic nodal MCL who presented with 
      subcutaneous nodules on his lower extremities after receiving multi-agent 
      chemotherapy. Biopsies showed a dense infiltrate of atypical, mitotically active, 
      monomorphic, medium-sized lymphoid cells in the subcutaneous fat with prominent 
      rimming of the adipocytes by the tumor cells. These features were not 
      morphologically typical of MCL. Immunohistochemistry showed these cells to be 
      CD20+, CD5+ B-cells with strong cyclin D1 expression; fluorescence in situ 
      hybridization (FISH) analysis was positive for t(11;14)(q13;32), confirming the 
      diagnosis of secondary cutaneous involvement of MCL. This represents an 
      exceptional report of cutaneous MCL presenting clinically and histologically with 
      a panniculitis-type pattern and adipocyte rimming, histomorphologically mimicking 
      SPTCL. Noteworthy examples, such as this report, support the practice of 
      utilizing clinical correlation, immunohistochemistry, and/or molecular 
      cytogenetics to confirm the diagnosis of any case suspicious for cutaneous 
      lymphoma.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Laggis, Caroline
AU  - Laggis C
AUID- ORCID: 0000-0003-3819-9345
AD  - Department of Dermatology, University of Utah, Salt Lake City, Utah.
FAU - Miles, Rodney
AU  - Miles R
AD  - Department of Pathology, Division of Clinical Pathology, University of Utah, Salt 
      Lake City, Utah.
FAU - Stephens, Deborah M
AU  - Stephens DM
AD  - Division of Hematology and Hematologic Malignancies, Department of Internal 
      Medicine, University of Utah, Salt Lake City, Utah.
FAU - Duffy, Keith
AU  - Duffy K
AD  - Department of Dermatology, University of Utah, Salt Lake City, Utah.
FAU - Bowen, Anneli
AU  - Bowen A
AD  - Department of Dermatology, University of Utah, Salt Lake City, Utah.
FAU - Wada, David
AU  - Wada D
AD  - Department of Dermatology, University of Utah, Salt Lake City, Utah.
LA  - eng
PT  - Case Reports
DEP - 20190503
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Antigens, CD20)
RN  - 0 (CCND1 protein, human)
RN  - 0 (CD5 Antigens)
RN  - 136601-57-5 (Cyclin D1)
RN  - Subcutaneous panniculitis-like T-cell lymphoma
SB  - IM
MH  - Aged
MH  - Antigens, CD20/genetics/metabolism
MH  - B-Lymphocytes/metabolism/pathology
MH  - CD5 Antigens/genetics/metabolism
MH  - Chromosomes, Human, Pair 11/genetics/metabolism
MH  - Chromosomes, Human, Pair 14/genetics/metabolism
MH  - Cyclin D1/genetics/metabolism
MH  - Diagnosis, Differential
MH  - Humans
MH  - *Lymphoma, Mantle-Cell/diagnosis/genetics/metabolism/pathology
MH  - *Lymphoma, T-Cell/diagnosis/genetics/metabolism/pathology
MH  - Male
MH  - *Panniculitis/diagnosis/genetics/metabolism/pathology
MH  - *Skin Neoplasms/diagnosis/genetics/metabolism/pathology
MH  - Translocation, Genetic
EDAT- 2019/04/09 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/04/09 06:00
PHST- 2018/11/20 00:00 [received]
PHST- 2019/03/25 00:00 [revised]
PHST- 2019/04/01 00:00 [accepted]
PHST- 2019/04/09 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/04/09 06:00 [entrez]
AID - 10.1111/cup.13471 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2019 Jul;46(7):538-541. doi: 10.1111/cup.13471. Epub 2019 May 3.