PMID- 30958172
OWN - NLM
STAT- MEDLINE
DCOM- 20200226
LR  - 20231005
IS  - 1742-5662 (Electronic)
IS  - 1742-5689 (Print)
IS  - 1742-5662 (Linking)
VI  - 16
IP  - 150
DP  - 2019 Jan 31
TI  - HDPE/UHMWPE hybrid nanocomposites with surface functionalized graphene oxide 
      towards improved strength and cytocompatibility.
PG  - 20180273
LID - 10.1098/rsif.2018.0273 [doi]
LID - 20180273
AB  - High-density polyethylene (HDPE)-based and ultra-high molecular weight 
      polyethylene (UHMWPE)-based composites with carbonaceous reinforcements are being 
      widely investigated for biomedical applications. The enhancement of material 
      properties critically depends on the nature, amount and compatibility of the 
      reinforcement with the polymeric matrix. To this end, this study demonstrates the 
      efficacy of a 'dual' hybrid approach of incorporating modified inorganic 
      nanofiller into an optimized polyethylene blend. In particular, a unique 
      synthesis strategy was adopted to design a covalently bonded maleated 
      polyethylene (mPE) grafted modified graphene oxide (mGO) hybrid nanocomposite. In 
      this scheme, polyethyleneimine (PEI) was initially attached onto GO to synthesize 
      amine functionalized GO (GO-PEI). This is followed by mPE grafting, resulting in 
      mGO. Melt-extrusion together with injection moulding of a polymer mix (60% 
      HDPE-40% UHMWPE) with different proportions (less than or equal to 3 wt%) of 
      surface functionalized GO was conducted to develop nanocomposites of different 
      sizes and shapes. When compared with unreinforced PE blend, the nanocomposites 
      with 1 wt% mGO exhibited an increase in ultimate tensile strength by 120% (up to 
      65 MPa) and elastic modulus by 40% (up to 908 MPa). The uniform dispersion of 
      modified GO nanofillers, confirmed using X-ray micro-computed tomography and 
      transmission electron microscopy, facilitated effective interfacial adhesion and 
      compatibility with the hybrid polymer matrix. The variation in mechanical 
      properties with GO/mGO addition to PE blend was critically discussed in reference 
      to the structural modification of GO, crystallinity and nature of dispersion of 
      fillers. Importantly, the nanocomposites support the attachment and proliferation 
      of C2C12 murine myoblast cells over 3 days in culture in a statistically 
      insignificant manner with respect to polymer blends without any nanofiller. Taken 
      together, the experimental results suggest that HDPE/UHMWPE/mGO is a promising 
      biomaterial for bone tissue engineering applications.
FAU - Bhusari, Shardul Atul
AU  - Bhusari SA
AD  - 1 Laboratory for Biomaterials, Materials Research Centre, Indian Institute of 
      Science , Bangalore 560012 , India.
FAU - Sharma, Vidushi
AU  - Sharma V
AD  - 1 Laboratory for Biomaterials, Materials Research Centre, Indian Institute of 
      Science , Bangalore 560012 , India.
FAU - Bose, Suryasarathi
AU  - Bose S
AD  - 2 Department of Materials Engineering, Indian Institute of Science , Bangalore 
      560012 , India.
FAU - Basu, Bikramjit
AU  - Basu B
AD  - 1 Laboratory for Biomaterials, Materials Research Centre, Indian Institute of 
      Science , Bangalore 560012 , India.
AD  - 3 Centre for Biosystems Science and Engineering, Indian Institute of Science , 
      Bangalore 560012 , India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J R Soc Interface
JT  - Journal of the Royal Society, Interface
JID - 101217269
RN  - 0 (Polyethylenes)
RN  - 0 (graphene oxide)
RN  - 0 (ultra-high molecular weight polyethylene)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/*drug effects
MH  - Cell Line
MH  - Cell Proliferation/*drug effects
MH  - *Graphite/chemistry/pharmacology
MH  - *Materials Testing
MH  - Mice
MH  - Nanocomposites/*chemistry
MH  - *Polyethylenes/chemistry/pharmacology
MH  - Surface Properties
PMC - PMC6364642
OTO - NOTNLM
OT  - cytocompatibility
OT  - graphene oxide
OT  - high-density polyethylene/UHMWPE blend
OT  - mechanical properties
OT  - melt-extrusion
OT  - nanocomposites
COIS- We declare we have no competing interests.
EDAT- 2019/04/09 06:00
MHDA- 2020/02/27 06:00
PMCR- 2020/01/01
CRDT- 2019/04/09 06:00
PHST- 2019/04/09 06:00 [entrez]
PHST- 2019/04/09 06:00 [pubmed]
PHST- 2020/02/27 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - rsif20180273 [pii]
AID - 10.1098/rsif.2018.0273 [doi]
PST - ppublish
SO  - J R Soc Interface. 2019 Jan 31;16(150):20180273. doi: 10.1098/rsif.2018.0273.