PMID- 30959183
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20200225
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Print)
IS  - 1050-4648 (Linking)
VI  - 89
DP  - 2019 Jun
TI  - Identification of CD8alpha(+) dendritic cells in rainbow trout (Oncorhynchus mykiss) 
      intestine.
PG  - 309-318
LID - S1050-4648(19)30239-6 [pii]
LID - 10.1016/j.fsi.2019.04.001 [doi]
AB  - Dendritic cells (DCs) are professional antigen presenting cells located at 
      mucosal surfaces and lymphoid tissues. Their main role is to present antigens to 
      T cells and thus regulate the initiation of the acquired immune response and 
      modulate tolerance mechanisms towards self-antigens. Despite their relevance, not 
      many studies have addressed the identification and characterization of specific 
      DC subsets in teleost fish. Previous studies in our group identified a DC 
      subpopulation co-expressing CD8alpha and major histocompatibility complex II (MHC II) 
      on the cell surface in rainbow trout (Oncorhynchus mykiss) skin and gills. A 
      complete functional and phenotypical characterization of these cell subsets was 
      then undertaken, unequivocally recognizing them as DCs (CD8(+) DCs). In the 
      current study, we report the identification of a homologous population in rainbow 
      trout intestinal lamina propria (LP). We have studied the main features of these 
      intestinal CD8(+) DCs, comparing them to those of CD8(+) DCs from another mucosal 
      tissue (gills). Interestingly, intestinal CD8(+) DCs exhibited significant 
      phenotypical and functional differences when compared to gill CD8(+) DCs, 
      suggesting that the location of DCs strongly conditions their activation state. 
      These results will contribute to further expand our knowledge on how intestinal 
      immune responses are regulated in fish, helping us to rationally design oral 
      vaccines in the future.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Soleto, Irene
AU  - Soleto I
AD  - Animal Health Research Centre (CISA-INIA), 28130, Valdeolmos, Madrid, Spain.
FAU - Granja, Aitor G
AU  - Granja AG
AD  - Animal Health Research Centre (CISA-INIA), 28130, Valdeolmos, Madrid, Spain.
FAU - Simon, Rocio
AU  - Simon R
AD  - Animal Health Research Centre (CISA-INIA), 28130, Valdeolmos, Madrid, Spain.
FAU - Morel, Esther
AU  - Morel E
AD  - Animal Health Research Centre (CISA-INIA), 28130, Valdeolmos, Madrid, Spain.
FAU - Diaz-Rosales, Patricia
AU  - Diaz-Rosales P
AD  - Animal Health Research Centre (CISA-INIA), 28130, Valdeolmos, Madrid, Spain.
FAU - Tafalla, Carolina
AU  - Tafalla C
AD  - Animal Health Research Centre (CISA-INIA), 28130, Valdeolmos, Madrid, Spain. 
      Electronic address: tafalla@inia.es.
LA  - eng
PT  - Journal Article
DEP - 20190406
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
MH  - *Adaptive Immunity
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Gills/physiology
MH  - Intestines/*immunology
MH  - Oncorhynchus mykiss/*immunology
PMC - PMC6525785
OTO - NOTNLM
OT  - Antigen presentation
OT  - Cross-presentation
OT  - Dendritic cells (DCs)
OT  - Intestine
OT  - Rainbow trout
OT  - Teleost fish
EDAT- 2019/04/09 06:00
MHDA- 2019/07/28 06:00
PMCR- 2019/06/01
CRDT- 2019/04/09 06:00
PHST- 2018/10/04 00:00 [received]
PHST- 2019/03/22 00:00 [revised]
PHST- 2019/04/02 00:00 [accepted]
PHST- 2019/04/09 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
PHST- 2019/04/09 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - S1050-4648(19)30239-6 [pii]
AID - 10.1016/j.fsi.2019.04.001 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2019 Jun;89:309-318. doi: 10.1016/j.fsi.2019.04.001. Epub 
      2019 Apr 6.