PMID- 30960312
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Feb 13
TI  - Self-Association Behavior of Cell Membrane-Inspired Amphiphilic Random Copolymers 
      in Water.
LID - 10.3390/polym11020327 [doi]
LID - 327
AB  - Water-soluble and amphiphilic random copolymers (P(MPC/DMA(x))) composed of 
      hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) and hydrophobic 
      n-dodecyl methacrylate (DMA) were prepared via reversible addition-fragmentation 
      chain transfer (RAFT) controlled radical polymerization. The compositions of DMA 
      unit (x) in the copolymer were in the range of 0 to 38 unit mol %. The degree of 
      polymerization of P(MPC/DMA(x)) was adjusted to about 200. Since the monomer 
      reactivity ratios of MPC and DMA are 1.01 and 1.00, respectively, ideal free 
      radical copolymerization occurred. In aqueous solutions, interpolymer aggregation 
      occurred due to the hydrophobic pendant n-dodecyl groups. The aggregation number 
      (N(agg)) increased with an increasing x. The mobilities of the DMA and MPC 
      pendant groups in aqueous solutions were restricted, as confirmed by (1)H NMR 
      relaxation time measurements, because a part of the MPC units were trapped in the 
      hydrophobic microdomain formed from the pendant n-dodecyl groups. The polarity of 
      the hydrophobic microdomain formed from P(MPC/DMA(38)) in water was similar to 
      that of ethyl acetate according to fluorescence probe experiments. No specific 
      interactions were found in water between P(MPC/DMA(x)) and bovine serum albumin 
      because the surface of the interpolymer aggregates contained only hydrophilic MPC 
      units.
FAU - Ohshio, Maho
AU  - Ohshio M
AD  - Department of Applied Chemistry, Graduate School of Engineering, University of 
      Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan. mh11milk@gmail.com.
FAU - Ishihara, Kazuhiko
AU  - Ishihara K
AD  - Department of Materials Engineering, School of Engineering, The University of 
      Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656, Japan. 
      ishihara@mpc.t.u-tokyo.ac.jp.
FAU - Yusa, Shin-Ichi
AU  - Yusa SI
AUID- ORCID: 0000-0002-2838-5200
AD  - Department of Applied Chemistry, Graduate School of Engineering, University of 
      Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan. yusa@eng.u-hyogo.ac.jp.
LA  - eng
GR  - 17H03071/JSPS/
GR  - 16K14008/JSPS/
GR  - 20184035/JSPS/
PT  - Journal Article
DEP - 20190213
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC6419178
OTO - NOTNLM
OT  - RAFT
OT  - amphiphilic copolymer
OT  - hydrophobic interaction
OT  - phosphorylcholine
COIS- The authors declare no conflict of interest.
EDAT- 2019/04/10 06:00
MHDA- 2019/04/10 06:01
PMCR- 2019/02/13
CRDT- 2019/04/10 06:00
PHST- 2019/01/26 00:00 [received]
PHST- 2019/02/11 00:00 [revised]
PHST- 2019/02/11 00:00 [accepted]
PHST- 2019/04/10 06:00 [entrez]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2019/04/10 06:01 [medline]
PHST- 2019/02/13 00:00 [pmc-release]
AID - polym11020327 [pii]
AID - polymers-11-00327 [pii]
AID - 10.3390/polym11020327 [doi]
PST - epublish
SO  - Polymers (Basel). 2019 Feb 13;11(2):327. doi: 10.3390/polym11020327.