PMID- 30961497
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20200803
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 16
IP  - 4
DP  - 2019
TI  - Is Brain-Derived Neurotrophic Factor: A Common Link Between Neurodegenerative 
      Disorders and Cancer?
PG  - 344-352
LID - 10.2174/1567205016666190408123947 [doi]
AB  - BACKGROUND: Cancer is a common disease caused by the excessive proliferation of 
      cells, and neurodegenerative diseases are the disorders caused due to the 
      degeneration of neurons. Both can be considered as diseases caused by the 
      dysregulation of cell cycle events. A recent data suggests that there is a strong 
      inverse association between cancer and neurodegenerative disorders. There is 
      indirect evidence to postulate Brain-derived Neurotrophic Factor (BDNF) as a 
      potential molecular link in this association. DISCUSSION: The BDNF levels are 
      found to be downregulated in many neurodegenerative disorders and are found to be 
      upregulated in various kinds of cancers. The lower level of BDNF in Alzheimer's 
      and Parkinson's disease has been found to be related to cognitive and other 
      neuropsychological impairments, whereas, its higher levels are associated with 
      the tumour growth and metastasis and poor survival rate in the cancer patients. 
      CONCLUSION: In this review, we propose that variance in BDNF levels is critical 
      in determining the course of cellular pathophysiology and the development of 
      cancer or neurodegenerative disorder. We further propose that an alternative 
      therapeutic strategy that can modulate BDNF expression, can rescue or prevent 
      above said pathophysiological course. Larger studies that examine this link 
      through animal studies are imperative to understand the putative biochemical and 
      molecular link to wellness and disease.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Khosla, Radhika
AU  - Khosla R
AD  - Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, Chandigarh, India.
FAU - Banik, Avijit
AU  - Banik A
AD  - Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, 
      United States.
FAU - Kaushal, Sushant
AU  - Kaushal S
AD  - Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, Chandigarh, India.
FAU - Battu, Priya
AU  - Battu P
AD  - Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, Chandigarh, India.
FAU - Gupta, Deepti
AU  - Gupta D
AD  - Department of English and Cultural Studies, Panjab University, Chandigarh, India.
FAU - Anand, Akshay
AU  - Anand A
AD  - Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, Chandigarh, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Neoplasms/*metabolism
MH  - Neurodegenerative Diseases/*metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BDNF
OT  - BDNF/TrkB cascade
OT  - alternative therapy
OT  - homeostasis
OT  - neurodegenerative disorders.
EDAT- 2019/04/10 06:00
MHDA- 2020/08/04 06:00
CRDT- 2019/04/10 06:00
PHST- 2018/08/08 00:00 [received]
PHST- 2019/03/06 00:00 [revised]
PHST- 2019/03/08 00:00 [accepted]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2019/04/10 06:00 [entrez]
AID - CAR-EPUB-97892 [pii]
AID - 10.2174/1567205016666190408123947 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2019;16(4):344-352. doi: 10.2174/1567205016666190408123947.