PMID- 30962807
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2019
DP  - 2019
TI  - Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with 
      Different Renal Functions.
PG  - 4353075
LID - 10.1155/2019/4353075 [doi]
LID - 4353075
AB  - AIM: Recent studies found that levels of serum uric acid (SUA) were positively 
      associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 
      diabetes mellitus (T2DM). In the current study, we investigated the association 
      between 1,5-AG and UA in T2DM patients with different renal functions. METHODS: A 
      total of 405 T2DM patients, 213 men and 192 women, participated in the study. 
      Patients' clinical information was collected, and serum 1,5-AG, SUA, and other 
      clinical characteristics were measured. Correlation analyses were carried out to 
      analyze their correlation with serum 1,5-AG and SUA. RESULTS: The male group 
      showed higher levels of SUA than the female group (282.1 +/- 91.2 and 
      244.7 +/- 71.89 mumol/L, respectively, P < 0.01). Pearson's correlation coefficients 
      determine that SUA was positively associated with 1,5-AG in both men (r = 0.213, 
      P < 0.05) and women (r = 0.223, P < 0.05), and such relationship can be 
      influenced by the renal function. The positive association still existed with 
      moderate impaired renal function. Moreover, 1,5-AG had a negative association 
      with haemoglobin A1c (HbA1c) in T2DM subjects with eGFR >/= 30 mL/min/1.73 m(2) (P 
      < 0.01). CONCLUSION: The positive association between SUA and 1,5-AG still exists 
      in T2DM with moderate renal failure. 1,5-AG can still reflect the glucose levels 
      in patients with CKD stages 1-3.
FAU - Zhang, Kai
AU  - Zhang K
AD  - Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical 
      School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu 
      Province, China.
FAU - Xue, Bizhen
AU  - Xue B
AD  - Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical 
      School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu 
      Province, China.
FAU - Yuan, Yuexing
AU  - Yuan Y
AD  - Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical 
      School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu 
      Province, China.
FAU - Wang, Yao
AU  - Wang Y
AUID- ORCID: 0000-0002-7707-1339
AD  - Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical 
      School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu 
      Province, China.
LA  - eng
PT  - Journal Article
DEP - 20190306
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC6431393
EDAT- 2019/04/10 06:00
MHDA- 2019/04/10 06:01
PMCR- 2019/03/06
CRDT- 2019/04/10 06:00
PHST- 2018/06/16 00:00 [received]
PHST- 2018/10/01 00:00 [revised]
PHST- 2018/10/14 00:00 [accepted]
PHST- 2019/04/10 06:00 [entrez]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2019/04/10 06:01 [medline]
PHST- 2019/03/06 00:00 [pmc-release]
AID - 10.1155/2019/4353075 [doi]
PST - epublish
SO  - Int J Endocrinol. 2019 Mar 6;2019:4353075. doi: 10.1155/2019/4353075. eCollection 
      2019.