PMID- 30962830
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1857-9655 (Print)
IS  - 1857-9655 (Electronic)
IS  - 1857-9655 (Linking)
VI  - 7
IP  - 5
DP  - 2019 Mar 15
TI  - Differences in Brain-Derived Neurotrophic Factor and Matrix Metalloproteinase-9 
      between Appropriate Neonates between Normal Birth Weight and Intrauterine Growth 
      Restriction.
PG  - 736-741
LID - 10.3889/oamjms.2019.159 [doi]
AB  - BACKGROUND: Intrauterine Growth Restriction (IUGR) was defined as the growth of 
      the fetus less than its normal potential growth due to genetic and environmental 
      factors. One of the most widely believed causes of IUGR was impaired 
      uteroplacental mechanism from mother to fetus. Furthermore, factor which was 
      thought to affect placental growth was due to the influence of Brain-Derived 
      Neurotrophic Factor (BDNF) and Matrix Metalloproteinase (MMP-9) which play an 
      important role in angiogenesis. AIM: This study aims to determine differences in 
      Brain-Derived Neurotrophic Factor (BDNF) and moderately mature Matrix 
      Metalloproteinase (MMP-9) between normal birth weight and intrauterine growth 
      restriction. MATERIAL AND METHODS: The study design was a cross-sectional study 
      at four hospitals in Padang city from August 2017-January 2018. The sample of 
      this study was umbilical cord blood of appropriate gestational age neonate with 
      normal birth weight (31 neonates) and IUGR (31 neonates) by consecutive sampling, 
      samples taken from mothers who meet inclusion criteria. BDNF and MMP-9 levels 
      were analysed by ELISA. The differences between normal birth weight and IUGR test 
      were followed by unpaired T-test. RESULTS: The results showed that BDNF levels in 
      normal neonates was 1.58 +/- 0.23 ng/ml and in IUGR neonates were 1.25 +/- 0.35 ng/ml 
      (p = 0.001). MMP-9 levels in normal neonates was 1.09 +/- 0.20 ng/ml and in IUGR 
      neonates were 1.25 +/- 0.35 (p = 0.03). CONCLUSION: The conclusion of this study 
      was BDNF of moderately mature neonates was significantly higher in normal birth 
      weight compared to intrauterine growth restriction, and the moderately high MMP-9 
      neonates were significantly higher in intrauterine growth restriction compared 
      with normal birth weight.
FAU - Ardiani, Yessi
AU  - Ardiani Y
AD  - Postgraduate Program in Midwifery Science, Faculty of Medicine, Andalas 
      University, Padang, Indonesia.
FAU - Defrin, Defrin
AU  - Defrin D
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, 
      Padang, Indonesia.
FAU - Yetti, Husna
AU  - Yetti H
AD  - Department of Public Health, Faculty of Medicine, Andalas University, Padang, 
      Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20190314
PL  - North Macedonia
TA  - Open Access Maced J Med Sci
JT  - Open access Macedonian journal of medical sciences
JID - 101662294
PMC - PMC6447354
OTO - NOTNLM
OT  - BDNF
OT  - IUGR
OT  - MMP-9
OT  - Normal birth weight
EDAT- 2019/04/10 06:00
MHDA- 2019/04/10 06:01
PMCR- 2019/03/14
CRDT- 2019/04/10 06:00
PHST- 2018/12/22 00:00 [received]
PHST- 2019/02/06 00:00 [revised]
PHST- 2019/02/07 00:00 [accepted]
PHST- 2019/04/10 06:00 [entrez]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2019/04/10 06:01 [medline]
PHST- 2019/03/14 00:00 [pmc-release]
AID - OAMJMS-7-736 [pii]
AID - 10.3889/oamjms.2019.159 [doi]
PST - epublish
SO  - Open Access Maced J Med Sci. 2019 Mar 14;7(5):736-741. doi: 
      10.3889/oamjms.2019.159. eCollection 2019 Mar 15.