PMID- 30963135
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 3
IP  - 4
DP  - 2019 Apr 1
TI  - Diabetes Mellitus-Related Fractional Glucose Uptake in Men and Women Imaged With 
      (18)F-FDG PET-CT.
PG  - 773-783
LID - 10.1210/js.2019-00001 [doi]
AB  - CONTEXT: Cohort studies show that cognitive dysfunction and both vascular and 
      Alzheimer's dementia are more common in patients with type 2 diabetes mellitus 
      (T2DM). OBJECTIVE: To review and compare brain volume and 
      (18)F-fluorodeoxyglucose (FDG) uptake in brain of individuals age 60 to 70 years 
      with or without type 2 diabetes. DESIGN: We searched 620 medical records for 
      negative (18)FDG PET-CT scans obtained during 33 months. Records showing history 
      of cognitive impairment, Alzheimer's disease, neurologic disorders, any history 
      of brain atrophy, or documented cerebral infarction on neuroimaging were excluded 
      from the study. RESULTS: A total of 119 medical records met the inclusion 
      criteria. Data from 63 women and 56 men (without T2DM, 86; with T2DM, 33) were 
      analyzed. Brain volume was larger in men than women (mean +/- SD, 1411 +/- 225 cm(3) 
      vs 1325 +/- 147 cm(3), respectively; P = 0.02), but men had a significantly lower 
      fractional glucose uptake (SUV(gluc)), calculated as fasting blood glucose x 
      SUV(max.) [median (minimum, maximum), 63.6 (34.6, 126.6) vs 70.0 (36.4, 134.3); P 
      = 0.02]. Brain volume was also larger in persons without T2DM than in those with 
      T2DM (1392 +/- 172 cm(3) vs 1269 +/- 183 cm(3); P < 0.001), but SUV(gluc) was similar 
      between these groups. Brain volume correlated with SUV(gluc) in both men and 
      women overall (P < 0.001) but not in men and women with T2DM (P = 0.20 and 0.36, 
      respectively). CONCLUSION: In men without T2DM, median brain volume was larger 
      and fractional glucose uptake was less than in women without T2DM. In men and 
      women with T2DM, brain volume and fractional glucose uptake were similar. The 
      findings support the hypothesis that fractional glucose uptake becomes impaired 
      in men with T2DM.
FAU - Waqas, Komal
AU  - Waqas K
AUID- ORCID: 0000-0001-6005-9264
AD  - Department of Internal Medicine and Endocrinology, Reinier the Graaf Hospital, 
      Delft, Netherlands.
FAU - van Haard, Paul M M
AU  - van Haard PMM
AD  - Department of Medical Laboratories, Association of Clinical Chemistry, Reinier 
      the Graaf Hospital, Delft, Netherlands.
FAU - Postema, Jan W A
AU  - Postema JWA
AD  - Department of Nuclear Medicine, Reinier de Graaf Gasthuis, Delft, Netherlands.
FAU - Schweitzer, Dave H
AU  - Schweitzer DH
AD  - Department of Internal Medicine and Endocrinology, Reinier the Graaf Hospital, 
      Delft, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20190227
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC6446889
OTO - NOTNLM
OT  - 18-FDG PET-CT
OT  - brain
OT  - fractional glucose uptake
OT  - type 2 diabetes
EDAT- 2019/04/10 06:00
MHDA- 2019/04/10 06:01
PMCR- 2019/02/27
CRDT- 2019/04/10 06:00
PHST- 2019/01/01 00:00 [received]
PHST- 2019/02/22 00:00 [accepted]
PHST- 2019/04/10 06:00 [entrez]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2019/04/10 06:01 [medline]
PHST- 2019/02/27 00:00 [pmc-release]
AID - js_201900001 [pii]
AID - 10.1210/js.2019-00001 [doi]
PST - epublish
SO  - J Endocr Soc. 2019 Feb 27;3(4):773-783. doi: 10.1210/js.2019-00001. eCollection 
      2019 Apr 1.