PMID- 30963454
OWN - NLM
STAT- MEDLINE
DCOM- 20200110
LR  - 20200225
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 51
IP  - 7
DP  - 2019 Jul
TI  - Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney 
      disease stage 3-5: is it significant?
PG  - 1229-1230
LID - 10.1007/s11255-019-02136-y [doi]
AB  - PURPOSE: To study the incidence of lactic acidosis due to metformin in patients 
      with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) stage 3-5. 
      METHODS: We estimated plasma lactate in patients of CKD stage 3 and worse who 
      were continuing metformin on their own prior to stopping the drug. RESULT: Of 40 
      patients included, median duration of T2DM was 60 months (interquartile range IQR 
      24-120). The mean serum creatinine was 309.4 +/- 159.1 micromol/L and mean eGFR was 
      27.82 +/- 12.93 mL/min/1.73 m(2) with 3 (7.5%), 16 (40%), 11 (27.5%) and 10 (25%) 
      in CKD stages 3a, 3b, 4 and 5, respectively. They were receiving metformin for a 
      median duration of 24 months (IQR 12.5-60), an average dose of 896 +/- 350 mg per 
      day. The median of plasma lactate was 1.36 mmol/L (IQR 1.11-1.75 mmol/L) with 
      three (7.5%) having levels above normal, two (20%) in CKD stage 5 and one (9.1%) 
      in stage 4. CONCLUSION: Metformin can be safely used in CKD stage 3 and with 
      regular measurement of plasma lactate in later stages.
FAU - Prabhu, Ravindra Attur
AU  - Prabhu RA
AUID- ORCID: 0000-0002-5980-7197
AD  - Department of Nephrology, Kasturba Medical College and Hospital Manipal, Manipal 
      Academy Higher Education, Madhav Nagar, Manipal, Udupi, Karnataka, 576104, India. 
      aravindraprabhu@gmail.com.
FAU - Mareddy, Aswani Srinivas
AU  - Mareddy AS
AD  - Department of Nephrology, Kasturba Medical College and Hospital Manipal, Manipal 
      Academy Higher Education, Madhav Nagar, Manipal, Udupi, Karnataka, 576104, India.
FAU - Nagaraju, Shankar Prasad
AU  - Nagaraju SP
AD  - Department of Nephrology, Kasturba Medical College and Hospital Manipal, Manipal 
      Academy Higher Education, Madhav Nagar, Manipal, Udupi, Karnataka, 576104, India.
FAU - Rangaswamy, Dharshan
AU  - Rangaswamy D
AD  - Department of Nephrology, Kasturba Medical College and Hospital Manipal, Manipal 
      Academy Higher Education, Madhav Nagar, Manipal, Udupi, Karnataka, 576104, India.
FAU - Guddattu, Vasudeva
AU  - Guddattu V
AD  - Department of Statistics, Prasanna School of Public Health, MAHE, Udupi, India.
LA  - eng
GR  - seed grant/Manipal University/
PT  - Journal Article
DEP - 20190408
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (Hypoglycemic Agents)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9100L32L2N (Metformin)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - *Acidosis, Lactic/blood/chemically induced/diagnosis/prevention & control
MH  - Creatinine/blood
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Monitoring/methods
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage/adverse effects
MH  - Lactic Acid/*blood
MH  - Male
MH  - Metformin/administration & dosage/adverse effects
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - *Renal Insufficiency, Chronic/complications/diagnosis
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Lactic acidosis
OT  - Metformin
OT  - Type 2 diabetes mellitus
EDAT- 2019/04/10 06:00
MHDA- 2020/01/11 06:00
CRDT- 2019/04/10 06:00
PHST- 2019/03/04 00:00 [received]
PHST- 2019/03/26 00:00 [accepted]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2020/01/11 06:00 [medline]
PHST- 2019/04/10 06:00 [entrez]
AID - 10.1007/s11255-019-02136-y [pii]
AID - 10.1007/s11255-019-02136-y [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2019 Jul;51(7):1229-1230. doi: 10.1007/s11255-019-02136-y. Epub 
      2019 Apr 8.