PMID- 30963961
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20190729
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 26
IP  - 13
DP  - 2019
TI  - Recent Advance in Polymer Based Microspheric Systems for Controlled Protein and 
      Peptide Delivery.
PG  - 2285-2296
LID - 10.2174/0929867326666190409130207 [doi]
AB  - Sustained-release systems made by biodegradable polymers for protein and peptide 
      drug delivery have received considerable attention by academic researchers and 
      major pharmaceutical companies around the world. Various types of biodegradable 
      materials, including natural and synthetic polymers, have been applied to form 
      protein and peptide drug carriers. Among these material candidates, poly lactic 
      acid (PLA) and poly lactic-co-glycolic acid (PLGA) are the most commonly used 
      biodegradable materials in the development of protein and peptide microspheres. 
      In addition, many microsphere preparation technologies, including spray drying, 
      coacervation, multiple emulsion solvent evaporation method and microporous 
      membrane emulsification have been developed for microspheres preparation. In this 
      review, we particularly summarize and briefly introduce the materials and methods 
      that are used to fabricate microspheres as protein delivery systems. The existing 
      opportunities and challenges for successful protein delivery are also discussed.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Yang, Yuanyuan
AU  - Yang Y
AD  - Guangdong Provincial Key Laboratory of New Drug Screening, School of 
      Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
FAU - Chen, Qiling
AU  - Chen Q
AD  - Guangdong Provincial Key Laboratory of New Drug Screening, School of 
      Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
FAU - Lin, Jianyu
AU  - Lin J
AD  - Guangdong Provincial Key Laboratory of New Drug Screening, School of 
      Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
FAU - Cai, Zheng
AU  - Cai Z
AD  - Guangdong Provincial Key Laboratory of New Drug Screening, School of 
      Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
FAU - Liao, Guochao
AU  - Liao G
AD  - International Institute for Translational Chinese Medicine, Guangzhou University 
      of Chinese Medicine, Guangzhou, Guangdong 510006, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Department of Chemical and Biomedical Engineering, West Virginia University, 
      Morgantown, WV, 26505, United States.
FAU - Bai, Lei
AU  - Bai L
AD  - Department of Chemical and Biomedical Engineering, West Virginia University, 
      Morgantown, WV, 26505, United States.
FAU - Zhao, Peng
AU  - Zhao P
AD  - Guangdong Provincial Key Laboratory of New Drug Screening, School of 
      Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
FAU - Yu, Zhiqiang
AU  - Yu Z
AD  - Guangdong Provincial Key Laboratory of New Drug Screening, School of 
      Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 0 (Peptides)
RN  - 0 (Polymers)
RN  - 0 (Proteins)
MH  - Delayed-Action Preparations/chemistry
MH  - Drug Carriers/*chemistry
MH  - Drug Compounding
MH  - Microfluidics/methods
MH  - *Microspheres
MH  - Peptides/*chemistry
MH  - Polymers/*chemistry
MH  - Proteins/*chemistry
OTO - NOTNLM
OT  - Sustained-release system
OT  - biodegradeable materials
OT  - drug delivery
OT  - microporous membrane emulsification technology
OT  - microspheres
OT  - protein and peptide drugs
OT  - tissue engineering.
EDAT- 2019/04/10 06:00
MHDA- 2019/07/30 06:00
CRDT- 2019/04/10 06:00
PHST- 2017/04/17 00:00 [received]
PHST- 2018/04/10 00:00 [revised]
PHST- 2018/05/31 00:00 [accepted]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2019/04/10 06:00 [entrez]
AID - CMC-EPUB-97958 [pii]
AID - 10.2174/0929867326666190409130207 [doi]
PST - ppublish
SO  - Curr Med Chem. 2019;26(13):2285-2296. doi: 10.2174/0929867326666190409130207.