PMID- 30964204
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20200214
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 58
IP  - 9
DP  - 2019 Sep
TI  - Association of antioxidants and vitamin D level with inflammation in children 
      with atopic dermatitis.
PG  - 1056-1061
LID - 10.1111/ijd.14438 [doi]
AB  - BACKGROUND: Changing the resources of vitamin D and antioxidant nutrients may 
      affect the course of allergic diseases. The aim of the study was to investigate 
      the association between CoQ10, vitamin D, retinol, and alpha-tocopherol serum levels 
      and severity of atopic dermatitis (AD) in children. METHODS: Twenty-nine children 
      with AD aged from 1 to 15 years were enrolled into the study. The severity of AD 
      was categorized into mild or moderate (</=50 points in SCORAD - Scoring Atopic 
      Dermatitis index) and severe (>50 SCORAD points). The control group was comprised 
      of 22 children with negative history of allergy aged from 2 to 15. The serum 
      measurements included vitamin D, retinol, alpha-tocopherol, CoQ10, C-reactive protein 
      (CRP), complete blood count (CBC), and total immunoglobulin E (IgE). RESULTS: Low 
      vitamin D concentration (<20 ng/ml) was observed mainly in patients with severe 
      AD (77.8%), compared to children with mild or moderate AD (25%) or the control 
      group (31.8%). Concentration of retinol was decreased significantly in patients 
      with severe AD (median 1.32 mumol/l), compared to children with mild and moderate 
      AD (median 1.66 mumol/l), but not to the control. Among inflammatory markers, only 
      the group with severe AD demonstrated significantly elevated platelet count 
      (PLT), red blood cell distribution width (RDW), and eosinophil count (EO). 
      Retinol level correlated with PLT (R = -0.7; P = 0.003), white blood count (WBC) 
      (R = -0.54; P = 0.01), total IgE (R = -0.51; P = 0.016), mean platelet volume 
      (MPV) (R = 0.51; P = 0.02), and also with a disease severity index, SCORAD 
      (R = -0.55; P = 0.007), whereas vitamin D level correlated only with MPV 
      (R = 0.61; P = 0.003). No significant changes were found in tocopherol and CoQ10 
      levels between groups. CONCLUSIONS: Children with AD should be routinely tested 
      for vitamin D deficiency, especially during disease exacerbation. Our results 
      confirmed correlation of serum inflammatory markers with decreased concentration 
      of vitamin A in children with AD. This finding, however, might be an effect of 
      severe stage of disease and not only of inadequate intake of retinol in the diet.
CI  - (c) 2019 The International Society of Dermatology.
FAU - Daniluk, Urszula
AU  - Daniluk U
AUID- ORCID: 0000-0002-1671-6578
AD  - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and 
      Allergology, Medical University of Bialystok, Bialystok, Poland.
FAU - Filimoniuk, Aleksandra
AU  - Filimoniuk A
AD  - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and 
      Allergology, Medical University of Bialystok, Bialystok, Poland.
FAU - Kowalczuk-Kryston, Monika
AU  - Kowalczuk-Kryston M
AD  - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and 
      Allergology, Medical University of Bialystok, Bialystok, Poland.
FAU - Alifier, Marek
AU  - Alifier M
AD  - Department of Clinical Immunology, Medical University of Bialystok, Bialystok, 
      Poland.
FAU - Karpinska, Joanna
AU  - Karpinska J
AD  - Institute of Chemistry, University of Bialystok, Bialystok, Poland.
FAU - Kaczmarski, Maciej G
AU  - Kaczmarski MG
AD  - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and 
      Allergology, Medical University of Bialystok, Bialystok, Poland.
FAU - Lebensztejn, Dariusz M
AU  - Lebensztejn DM
AD  - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and 
      Allergology, Medical University of Bialystok, Bialystok, Poland.
LA  - eng
PT  - Journal Article
DEP - 20190409
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Biomarkers)
RN  - 11103-57-4 (Vitamin A)
RN  - 1339-63-5 (Ubiquinone)
RN  - 1406-16-2 (Vitamin D)
RN  - EJ27X76M46 (coenzyme Q10)
RN  - R0ZB2556P8 (Tocopherols)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/blood/*diagnosis/pathology
MH  - Disease Progression
MH  - Feeding Behavior
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Poland
MH  - Prospective Studies
MH  - *Severity of Illness Index
MH  - Tocopherols/blood
MH  - Ubiquinone/analogs & derivatives/blood
MH  - Vitamin A/*blood
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/blood/*diagnosis
EDAT- 2019/04/10 06:00
MHDA- 2020/02/15 06:00
CRDT- 2019/04/10 06:00
PHST- 2018/09/20 00:00 [received]
PHST- 2019/01/25 00:00 [revised]
PHST- 2019/02/28 00:00 [accepted]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/04/10 06:00 [entrez]
AID - 10.1111/ijd.14438 [doi]
PST - ppublish
SO  - Int J Dermatol. 2019 Sep;58(9):1056-1061. doi: 10.1111/ijd.14438. Epub 2019 Apr 
      9.