PMID- 3096494
OWN - NLM
STAT- MEDLINE
DCOM- 19870116
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 386
IP  - 1-2
DP  - 1986 Oct 29
TI  - The role of the nucleus raphe pontis and the caudate nucleus in alfentanil 
      rigidity in the rat.
PG  - 280-6
AB  - Attempts to eliminate or reduce the rigidity induced with high-dose narcotic 
      anesthesia in the operating room have been only partially successful. Previous 
      investigations of opioid receptor sites mediating this rigidity have implicated 
      two central regions: the nucleus raphe pontis (NRP) within the reticular 
      formation and the caudate nucleus (CN) within the basal ganglia. The present 
      study used systemically administered alfentanil (ALF), a potent, short-acting 
      fentanyl analog, and intracerebrally infused methylnaloxonium (MN), a quaternary 
      derivative of naloxone, to elucidate further the functional role of the NRP and 
      CN in rigidity. ALF (0.5 mg/kg s.c.) produced a reliable model of rigidity, as 
      documented by gastrocnemius electromyography. The onset of this rigidity was 
      within 60 s of ALF administration, with a total duration of approximately 40-50 
      min. Intracerebroventricular (i.c.v.) injections of 2.0 or 4.0 micrograms of MN 
      15 min prior to ALF treatment prevented rigidity, while 0.125 or 0.5 microgram 
      had no significant effect on rigidity. MN injected directly into the NRP at doses 
      as low as 0.125 microgram significantly antagonized ALF-induced rigidity, while 
      injections of MN into the caudate nucleus at doses as high as 4.0 micrograms 
      failed to antagonize ALF-induced rigidity. These observations demonstrate that 
      injection of MN into the NRP is at least 16-fold more effective in blocking 
      ALF-induced rigidity than MN injected into the ventricle and, more importantly, 
      at least 32-fold more effective than MN injected into the CN. The results suggest 
      that the NRP may be an important site for the neural control of muscular rigidity 
      associated with high-dose narcotic administration.
FAU - Blasco, T A
AU  - Blasco TA
FAU - Lee, D
AU  - Lee D
FAU - Amalric, M
AU  - Amalric M
FAU - Swerdlow, N R
AU  - Swerdlow NR
FAU - Smith, N T
AU  - Smith NT
FAU - Koob, G F
AU  - Koob GF
LA  - eng
GR  - 01785/PHS HHS/United States
GR  - 03504/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 1N74HM2BS7 (Alfentanil)
RN  - 36B82AMQ7N (Naloxone)
RN  - 73232-50-5 (N-methylnaloxone)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Alfentanil
MH  - Animals
MH  - Catatonia/chemically induced
MH  - Caudate Nucleus/*drug effects
MH  - Electromyography
MH  - Fentanyl/*analogs & derivatives/toxicity
MH  - Male
MH  - Muscle Rigidity/*chemically induced
MH  - Naloxone/analogs & derivatives
MH  - Pons/*drug effects
MH  - Quaternary Ammonium Compounds
MH  - Raphe Nuclei/*drug effects
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1986/10/29 00:00
MHDA- 1986/10/29 00:01
CRDT- 1986/10/29 00:00
PHST- 1986/10/29 00:00 [pubmed]
PHST- 1986/10/29 00:01 [medline]
PHST- 1986/10/29 00:00 [entrez]
AID - 0006-8993(86)90164-2 [pii]
AID - 10.1016/0006-8993(86)90164-2 [doi]
PST - ppublish
SO  - Brain Res. 1986 Oct 29;386(1-2):280-6. doi: 10.1016/0006-8993(86)90164-2.