PMID- 30965207
OWN - NLM
STAT- MEDLINE
DCOM- 20190830
LR  - 20190830
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 131
DP  - 2019 Jun
TI  - Selenium alleviates oxidative stress and autophagy in lead-treated chicken 
      testes.
PG  - 146-152
LID - S0093-691X(19)30061-5 [pii]
LID - 10.1016/j.theriogenology.2019.03.015 [doi]
AB  - Lead (Pb) is an environmental pollutant and has toxic effect on birds. Selenium 
      (Se) has alleviative effect on Pb poisoning. This study investigated mitigative 
      effect of Se on autophagy in Pb-treated chicken testes. Seven-day-old male 
      chickens were randomly divided into four groups with 45 birds in each group. The 
      birds of the control group were offered drinking water (DW) and commercial diet 
      (CD) (0.49 mg/kg Se). The birds of the Se group were offered DW and CD containing 
      sodium selenite (SeCD) (1.00 mg/kg Se). The birds of the Pb group were offered DW 
      containing lead acetate (PbDW) (350.00 mg/L Pb) and CD. The birds of the Pb/Se 
      group were offered PbDW and SeCD. On the 30(th), 60(th), and 90(th) days, 
      respectively; histology, antioxidant indexes (hydrogen peroxide (H(2)O(2)), 
      catalase (CAT), total antioxidant capacity (TAOC), reduced glutathione (GSH), and 
      superoxide dismutase (SOD)), mRNA and protein levels of autophagy-related genes 
      (autophagy-related proteins 5, Beclin 1, Dynein, light chain 3 (LC3)-I, LC3-II, 
      and mammalian target of rapamycin (mTOR)) were performed in chicken testes. The 
      results of this study showed that Pb caused histological changes; increased 
      H(2)O(2) content; decreased CAT, TAOC, and SOD activities and GSH content; and 
      increased mRNA and protein levels of the above autophagy-related genes except 
      that mTOR decreased in chicken testes. Se alleviated the above changes. Se 
      alleviated histological damage, oxidative stress, and autophagy in the Pb-treated 
      chicken testes.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Huang, He
AU  - Huang H
AD  - College of Animal Science and Technology, Northeast Agricultural University, 
      Harbin, 150030, People's Republic of China.
FAU - Wang, Yan
AU  - Wang Y
AD  - College of Animal Science and Technology, Northeast Agricultural University, 
      Harbin, 150030, People's Republic of China.
FAU - An, Yang
AU  - An Y
AD  - College of Animal Science and Technology, Northeast Agricultural University, 
      Harbin, 150030, People's Republic of China.
FAU - Jiao, Wanying
AU  - Jiao W
AD  - College of Animal Science and Technology, Northeast Agricultural University, 
      Harbin, 150030, People's Republic of China.
FAU - Xu, Yanmin
AU  - Xu Y
AD  - College of Animal Science and Technology, Northeast Agricultural University, 
      Harbin, 150030, People's Republic of China.
FAU - Han, Qi
AU  - Han Q
AD  - College of Animal Science and Technology, Northeast Agricultural University, 
      Harbin, 150030, People's Republic of China.
FAU - Teng, Xiaojie
AU  - Teng X
AD  - Grassland Workstation in Heilongjiang Province, Harbin, 150030, People's Republic 
      of China. Electronic address: txj651007@163.com.
FAU - Teng, Xiaohua
AU  - Teng X
AD  - College of Animal Science and Technology, Northeast Agricultural University, 
      Harbin, 150030, People's Republic of China. Electronic address: 
      tengxiaohua@neau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190323
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 0 (Avian Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (RNA, Messenger)
RN  - 2P299V784P (Lead)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Autophagy/*drug effects
MH  - Avian Proteins/genetics/metabolism
MH  - Biomarkers/metabolism
MH  - *Chickens
MH  - Environmental Pollutants/*toxicity
MH  - Lead/*toxicity
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - RNA, Messenger/metabolism
MH  - Random Allocation
MH  - Selenium/*pharmacology
MH  - Testis/*drug effects
OTO - NOTNLM
OT  - Autophagy
OT  - Chicken
OT  - Lead
OT  - Oxidative stress
OT  - Selenium
OT  - Testis
EDAT- 2019/04/10 06:00
MHDA- 2019/08/31 06:00
CRDT- 2019/04/10 06:00
PHST- 2018/04/27 00:00 [received]
PHST- 2018/11/08 00:00 [revised]
PHST- 2019/03/18 00:00 [accepted]
PHST- 2019/04/10 06:00 [pubmed]
PHST- 2019/08/31 06:00 [medline]
PHST- 2019/04/10 06:00 [entrez]
AID - S0093-691X(19)30061-5 [pii]
AID - 10.1016/j.theriogenology.2019.03.015 [doi]
PST - ppublish
SO  - Theriogenology. 2019 Jun;131:146-152. doi: 10.1016/j.theriogenology.2019.03.015. 
      Epub 2019 Mar 23.