PMID- 30965275 OWN - NLM STAT- MEDLINE DCOM- 20191223 LR - 20191223 IS - 2211-0356 (Electronic) IS - 2211-0348 (Linking) VI - 31 DP - 2019 Jun TI - Plasma brain-derived neurotrophic factor (BDNF) and sphingosine-1-phosphat (S1P) are NOT the main mediators of neuroprotection induced by resistance training in persons with multiple sclerosis-A randomized controlled trial. PG - 106-111 LID - S2211-0348(19)30156-7 [pii] LID - 10.1016/j.msard.2019.03.029 [doi] AB - Resistance training (RT) has been shown to elicit neuroprotective effects in persons with multiple sclerosis (pwMS). Brain-derived neurotrophic factor (BDNF) and Sphingosine-1-phosphat (S1P) have been put forward as potent mediators of the neuroprotective effects induced by RT. However, while increases have been shown in acute and chronic circulating BDNF levels in pwMS following aerobic exercise alone or in combination with other exercise regimes, no studies have examined this in response to RT. As a novel 'proof-of-concept' approach, we therefore examined the effects of 24 weeks of RT on acute and chronic circulating BDNF and S1P levels in the same pwMS whom our group had previously observed RT-induced neuroprotective effects in (i.e. increased cortical thickness and preservation of whole brain volume). A total of n = 30 relapsing-remitting pwMS were randomized into a training group (TG: 24 weeks of progressive high intensity resistance training, 2 sessions per week; n = 16, age 44[40:51] years, EDSS score 3.0[2.0:3.5] (median[IQR]) or a control group (CG: 24 weeks of habitual lifestyle; n = 14, age 45[37:47] years, EDSS score 3.0[2.5:3.5]). Plasma levels of BDNF and S1P were assessed by ELISA kits before and after the 24-week intervention period. No within- or between group changes were observed in acute or chronic circulating levels of BDNF. A substantial proportion of the participants had S1P levels below the detection limit, yet no within- or between changes were observed in chronic S1P plasma levels in the remaining samples. Thus, the present findings do not support that circulating plasma BDNF or S1P levels are the main mediators of the neuroprotective effects previously reported in the same group of pwMS. CI - Copyright (c) 2019. Published by Elsevier B.V. FAU - Jorgensen, M L K AU - Jorgensen MLK AD - Section for Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, DK-8000 Aarhus, Denmark. FAU - Kjolhede, T AU - Kjolhede T AD - Section for Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, DK-8000 Aarhus, Denmark; Centre for Innovative Medical Technology, Odense University Hospital (OUH), Denmark. FAU - Dalgas, U AU - Dalgas U AD - Section for Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, DK-8000 Aarhus, Denmark. FAU - Hvid, L G AU - Hvid LG AD - Section for Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, DK-8000 Aarhus, Denmark. Electronic address: lhvid@ph.au.dk. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20190401 PL - Netherlands TA - Mult Scler Relat Disord JT - Multiple sclerosis and related disorders JID - 101580247 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Lysophospholipids) RN - 26993-30-6 (sphingosine 1-phosphate) RN - 7171WSG8A2 (BDNF protein, human) RN - NGZ37HRE42 (Sphingosine) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Female MH - Humans MH - Lysophospholipids/*blood MH - Male MH - Middle Aged MH - Multiple Sclerosis/*blood/prevention & control MH - *Neuroprotection MH - *Resistance Training MH - Sphingosine/*analogs & derivatives/blood MH - Treatment Outcome OTO - NOTNLM OT - Brain-derived neurotrophic factor (BDNF) OT - Multiple sclerosis OT - Neuroprotection OT - Resistance training EDAT- 2019/04/10 06:00 MHDA- 2019/12/24 06:00 CRDT- 2019/04/10 06:00 PHST- 2018/11/15 00:00 [received] PHST- 2019/02/25 00:00 [revised] PHST- 2019/03/31 00:00 [accepted] PHST- 2019/04/10 06:00 [pubmed] PHST- 2019/12/24 06:00 [medline] PHST- 2019/04/10 06:00 [entrez] AID - S2211-0348(19)30156-7 [pii] AID - 10.1016/j.msard.2019.03.029 [doi] PST - ppublish SO - Mult Scler Relat Disord. 2019 Jun;31:106-111. doi: 10.1016/j.msard.2019.03.029. Epub 2019 Apr 1.