PMID- 30965721
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 9
IP  - 9
DP  - 2017 Sep 5
TI  - Fabrication of Multi-Layered Lidocaine and Epinephrine-Eluting PLGA/Collagen 
      Nanofibers: In Vitro and In Vivo Study.
LID - 10.3390/polym9090416 [doi]
LID - 416
AB  - This study developed multi-layered lidocaine- and epinephrine-eluting 
      biodegradable poly[(d,l)-lactide-co-glyco lide] (PLGA)/collagen nanofibers. An 
      electrospinning technique was employed to fabricate the multi-layer biodegradable 
      drug-eluting nanofibers. After fabrication, the nanofibrous membranes were 
      characterized. The drug release characteristics were also investigated. In 
      addition, the in vivo efficacy of nanofibers for pain relief and hemostasis in 
      palatal oral wounds of rabbits were evaluated. Histological examinations were 
      also completed. The experimental results suggested that all nanofibers exhibited 
      good biocompatibility and eluted effective levels of lidocaine and epinephrine at 
      the initial stages of wound recovery.
FAU - Lee, Fu-Ying
AU  - Lee FY
AD  - Department of Periodontics, Division of Dentistry, Chang Gung Memorial Hospital, 
      Tao-Yuan 33305, Taiwan. fuying20@hotmail.com.
FAU - Lee, Demei
AU  - Lee D
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, 
      Taiwan. dmlee@mail.cgu.edu.tw.
FAU - Lee, Tzu-Chia
AU  - Lee TC
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, 
      Taiwan. joy820629@gmail.com.
FAU - Chen, Jan-Kan
AU  - Chen JK
AD  - Department of Physiology and Pharmacology, Chang Gung University, Tao-Yuan 33302, 
      Taiwan. jkc508@mail.cgu.edu.tw.
FAU - Wu, Ren-Chin
AU  - Wu RC
AD  - Department of Pathology, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan. 
      renchin.wu@gmail.com.
FAU - Liu, Kuan-Chieh
AU  - Liu KC
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, 
      Taiwan. harobinca@hotmail.com.
FAU - Liu, Shih-Jung
AU  - Liu SJ
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, 
      Taiwan. shihjung@mail.cgu.edu.tw.
AD  - Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Tao-Yuan 33305, 
      Taiwan. shihjung@mail.cgu.edu.tw.
LA  - eng
GR  - CMRPD3D0153/Chang Gung Memorial Hospital/
GR  - 104-2221-E-182-048-MY3/Ministry of Science and Technology/
PT  - Journal Article
DEP - 20170905
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC6418943
OTO - NOTNLM
OT  - PLGA
OT  - biodegradable nanofibers
OT  - collagen
OT  - epinephrine
OT  - lidocaine
COIS- The authors declare no conflict of interest.
EDAT- 2017/09/05 00:00
MHDA- 2017/09/05 00:01
PMCR- 2017/09/05
CRDT- 2019/04/11 06:00
PHST- 2017/08/09 00:00 [received]
PHST- 2017/08/30 00:00 [revised]
PHST- 2017/09/03 00:00 [accepted]
PHST- 2019/04/11 06:00 [entrez]
PHST- 2017/09/05 00:00 [pubmed]
PHST- 2017/09/05 00:01 [medline]
PHST- 2017/09/05 00:00 [pmc-release]
AID - polym9090416 [pii]
AID - polymers-09-00416 [pii]
AID - 10.3390/polym9090416 [doi]
PST - epublish
SO  - Polymers (Basel). 2017 Sep 5;9(9):416. doi: 10.3390/polym9090416.