PMID- 30965954
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 9
IP  - 12
DP  - 2017 Nov 28
TI  - The Multi-Template Molecularly Imprinted Polymer Based on SBA-15 for Selective 
      Separation and Determination of Panax notoginseng Saponins Simultaneously in 
      Biological Samples.
LID - 10.3390/polym9120653 [doi]
LID - 653
AB  - The feasible, reliable and selective multi-template molecularly imprinted 
      polymers (MT-MIPs) based on SBA-15 (SBA-15@MT-MIPs) for the selective separation 
      and determination of the trace level of ginsenoside Rb(1) (Rb(1)), ginsenoside Rg(1) 
      (Rg(1)) and notoginsenoside R(1) (R(1)) simultaneously from biological samples were 
      developed. The polymers were constructed by SBA-15 as support, Rb(1), Rg(1), R(1) as 
      multi-template, acrylamide (AM) as functional monomer and ethylene glycol 
      dimethacrylate (EGDMA) as cross-linker. The new synthetic SBA-15@MT-MIPs were 
      satisfactorily applied to solid-phase extraction (SPE) coupled with high 
      performance liquid chromatography (HPLC) for the separation and determination of 
      trace Rb(1), Rg(1) and R(1) in plasma samples. Under the optimized conditions, the 
      limits of detection (LODs) and quantitation (LOQs) of the proposed method for 
      Rb(1), Rg(1) and R(1) were in the range of 0.63(-)0.75 ng.mL(-1) and 2.1(-)2.5 ng.mL(-1), 
      respectively. The recoveries of R(1), Rb(1) and Rg(1) were obtained between 93.4% and 
      104.3% with relative standard deviations (RSDs) in the range of 3.3(-)4.2%. All 
      results show that the obtained SBA-15@MT-MIPs could be a promising prospect for 
      the practical application in the selective separation and enrichment of trace 
      Panax notoginseng saponins (PNS) in the biological samples.
FAU - Sun, Chenghong
AU  - Sun C
AD  - School of Pharmacy, Nanjing Medical University, Nanjing 211166, China. 
      sbh1173250588@163.com.
FAU - Wang, Jinhua
AU  - Wang J
AD  - Department of Pharmacy Intravenous Admixture Service, The First Affiliated 
      Hospital of Harbin Medical University, Harbin 150001, China. 
      wangjinhua.txd@126.com.
FAU - Huang, Jiaojiao
AU  - Huang J
AD  - School of Pharmacy, Nanjing Medical University, Nanjing 211166, China. 
      nydhjj_celia@163.com.
FAU - Yao, Dandan
AU  - Yao D
AD  - School of Pharmacy, Nanjing Medical University, Nanjing 211166, China. 
      18851726822@163.com.
FAU - Wang, Chong-Zhi
AU  - Wang CZ
AD  - Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical 
      Care, University of Chicago, Chicago, IL 60637, USA. cwang@dacc.uchicago.edu.
FAU - Zhang, Lei
AU  - Zhang L
AD  - School of Pharmacy, Nanjing Medical University, Nanjing 211166, China. 
      18851720730@163.com.
FAU - Hou, Shuying
AU  - Hou S
AD  - Department of Pharmacy Intravenous Admixture Service, The First Affiliated 
      Hospital of Harbin Medical University, Harbin 150001, China. 
      jmywpzzx@54dr.org.cn.
FAU - Chen, Lina
AU  - Chen L
AD  - School of Pharmacy, Nanjing Medical University, Nanjing 211166, China. 
      chenlina@njmu.edu.cn.
FAU - Yuan, Chun-Su
AU  - Yuan CS
AD  - Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical 
      Care, University of Chicago, Chicago, IL 60637, USA. cyuan@dacc.uchicago.edu.
LA  - eng
GR  - 81373895/National Natural Science Foundation of China/
GR  - 81173538/National Natural Science Foundation of China/
GR  - 2015RAQYJ092/The Scientific Research Foundation of Harbin Science and Technology 
      Bureau/
PT  - Journal Article
DEP - 20171128
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC6418985
OTO - NOTNLM
OT  - Panax notoginseng saponins
OT  - SBA-15
OT  - multi-template molecularly imprinted polymers
OT  - separation and determination
OT  - solid-phase extraction
COIS- The authors declare no conflict of interest.
EDAT- 2017/11/28 00:00
MHDA- 2017/11/28 00:01
PMCR- 2017/11/28
CRDT- 2019/04/11 06:00
PHST- 2017/10/20 00:00 [received]
PHST- 2017/11/23 00:00 [revised]
PHST- 2017/11/23 00:00 [accepted]
PHST- 2019/04/11 06:00 [entrez]
PHST- 2017/11/28 00:00 [pubmed]
PHST- 2017/11/28 00:01 [medline]
PHST- 2017/11/28 00:00 [pmc-release]
AID - polym9120653 [pii]
AID - polymers-09-00653 [pii]
AID - 10.3390/polym9120653 [doi]
PST - epublish
SO  - Polymers (Basel). 2017 Nov 28;9(12):653. doi: 10.3390/polym9120653.