PMID- 30965988
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 9
IP  - 12
DP  - 2017 Dec 8
TI  - Plateau-Shaped Flexible Polymer Microelectrode Array for Neural Recording.
LID - 10.3390/polym9120690 [doi]
LID - 690
AB  - Conventional polymer multielectrode arrays (MEAs) have limitations resulting from 
      a high Young's modulus, including low conformability and gaps between the 
      electrodes and neurons. These gaps are not a problem in soft tissues such as the 
      brain, due to the repopulation phenomenon. However, gaps can result in signal 
      degradation when recording from a fiber bundle, such as the spinal cord. Methods: 
      We propose a method for fabricating flexible polydimethylsiloxane (PDMS)-based 
      MEAs featuring plateau-shaped microelectrodes. The proposed fabrication technique 
      enables the electrodes on the surface of MEAs to make a tight connection to the 
      neurons, because the wire of the MEA is fabricated to be plateau-shaped, as the 
      Young's modulus of PDMS is similar to soft tissues and PDMS follows the curvature 
      of the neural tissue due to its high conformability compared to the other 
      polymers. Injury caused by the movement of the MEAs can therefore be minimized. 
      Each electrode has a diameter of 130 mum and the 8-channel array has a 
      center-to-center electrode spacing of 300 mum. The signal-to-noise ratio of the 
      plateau-shaped electrodes was larger than that of recessed electrodes because 
      there was no space between the electrode and neural cell. Reliable neural 
      recordings were possible by adjusting the position of the electrode during the 
      experiment without trapping air under the electrodes. Simultaneous multi-channel 
      neural recordings were successfully achieved from the spinal cord of rodents. We 
      describe the fabrication technique, electrode 3D profile, electrode impedance, 
      and MEA performance in in vivo experiments in rodents.
FAU - Kim, Jun-Min
AU  - Kim JM
AD  - Medical Device Research Center Medical & Health Device Division, Korea Testing 
      Laboratory, Seoul 52852, Korea. junmin83@gmail.com.
FAU - Im, Changkyun
AU  - Im C
AD  - Dental Research Institute, Seoul National University School of Dentistry, Seoul 
      03080, Korea. oingah@nate.com.
FAU - Lee, Woo Ram
AU  - Lee WR
AD  - Medical Device Research Center Medical & Health Device Division, Korea Testing 
      Laboratory, Seoul 52852, Korea. wool001@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20171208
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC6418796
OTO - NOTNLM
OT  - PDMS
OT  - PDMS etching
OT  - fabrication
OT  - multielectrode array (MEA)
OT  - plateau-shaped electrode
OT  - recessed electrode
OT  - spinal cord signal recording
OT  - underexposure
COIS- The authors declare no conflict of interest.
EDAT- 2017/12/08 00:00
MHDA- 2017/12/08 00:01
PMCR- 2017/12/08
CRDT- 2019/04/11 06:00
PHST- 2017/11/06 00:00 [received]
PHST- 2017/12/04 00:00 [revised]
PHST- 2017/12/05 00:00 [accepted]
PHST- 2019/04/11 06:00 [entrez]
PHST- 2017/12/08 00:00 [pubmed]
PHST- 2017/12/08 00:01 [medline]
PHST- 2017/12/08 00:00 [pmc-release]
AID - polym9120690 [pii]
AID - polymers-09-00690 [pii]
AID - 10.3390/polym9120690 [doi]
PST - epublish
SO  - Polymers (Basel). 2017 Dec 8;9(12):690. doi: 10.3390/polym9120690.