PMID- 30966698
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 10
IP  - 6
DP  - 2018 Jun 14
TI  - Preparation and Properties of 3D Printed Alginate(-)Chitosan Polyion Complex 
      Hydrogels for Tissue Engineering.
LID - 10.3390/polym10060664 [doi]
LID - 664
AB  - Three-dimensional (3D) printing holds great potential for preparing sophisticated 
      scaffolds for tissue engineering. As a result of the shear thinning properties of 
      an alginate solution, it is often used as 3D printing ink. However, it is 
      difficult to prepare scaffolds with complexity structure and high fidelity, 
      because the alginate solution has a low viscosity and alginate hydrogels prepared 
      with Ca(2+) crosslinking are mechanically weak. In this work, chitosan powders 
      were dispersed and swelled in an alginate solution, which could effectively 
      improve the viscosity of an alginate solution by 1.5(-)4 times. With the increase 
      of chitosan content, the shape fidelity of the 3D printed alginate(-)chitosan 
      polyion complex (AlCh PIC) hydrogels were improved. Scanning electron microscope 
      (SEM) photographs showed that the lateral pore structure of 3D printed hydrogels 
      was becoming more obvious. As a result of the increased reaction ion pairs in 
      comparison to the alginate hydrogels that were prepared with Ca(2+) crosslinking, 
      AlCh PIC hydrogels were mechanically strong, and the compression stress of 
      hydrogels at a 90% strain could achieve 1.4 MPa without breaking. In addition, 
      human adipose derived stem cells (hASCs) adhered to the 3D printed AlCh PIC 
      hydrogels and proliferated with time, which indicated that the obtained hydrogels 
      were biocompatible and could potentially be used as scaffolds for tissue 
      engineering.
FAU - Liu, Qiongqiong
AU  - Liu Q
AD  - School of Medicine, South China University of Technology, 382 Outer Ring Rd, 
      Guangzhou 510006, China. qingtaoli007@163.com.
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      South China University of Technology, 382 Outer Ring Rd, Guangzhou 510006, China. 
      qingtaoli007@163.com.
FAU - Li, Qingtao
AU  - Li Q
AD  - School of Medicine, South China University of Technology, 382 Outer Ring Rd, 
      Guangzhou 510006, China. qingtaoli007@163.com.
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      South China University of Technology, 382 Outer Ring Rd, Guangzhou 510006, China. 
      qingtaoli007@163.com.
FAU - Xu, Sheng
AU  - Xu S
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      South China University of Technology, 382 Outer Ring Rd, Guangzhou 510006, China. 
      13662466914@163.com.
AD  - School of Material Science and Engineering, South China University of Technology, 
      381 Wushan Rd, Guangzhou 510641, China. 13662466914@163.com.
FAU - Zheng, Qiujian
AU  - Zheng Q
AD  - Guangdong General Hospital, 106 Zhongshan Second Rd, Guangzhou 510080, China. 
      zqj650@126.com.
FAU - Cao, Xiaodong
AU  - Cao X
AD  - National Engineering Research Center for Tissue Restoration and Reconstruction, 
      South China University of Technology, 382 Outer Ring Rd, Guangzhou 510006, China. 
      caoxd@scut.edu.cn.
AD  - School of Material Science and Engineering, South China University of Technology, 
      381 Wushan Rd, Guangzhou 510641, China. caoxd@scut.edu.cn.
LA  - eng
GR  - Grant No., 21574045/National Natural Science Foundation of China/
GR  - Grant No.2017ZD003/Fundamental Research Funds for the Central Universities/
PT  - Journal Article
DEP - 20180614
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC6404366
OTO - NOTNLM
OT  - 3D printed hydrogels
OT  - alginate
OT  - chitosan
OT  - polyion complex
COIS- The authors declare no conflict of interest.
EDAT- 2019/04/11 06:00
MHDA- 2019/04/11 06:01
PMCR- 2018/06/14
CRDT- 2019/04/11 06:00
PHST- 2018/05/09 00:00 [received]
PHST- 2018/06/08 00:00 [revised]
PHST- 2018/06/09 00:00 [accepted]
PHST- 2019/04/11 06:00 [entrez]
PHST- 2019/04/11 06:00 [pubmed]
PHST- 2019/04/11 06:01 [medline]
PHST- 2018/06/14 00:00 [pmc-release]
AID - polym10060664 [pii]
AID - polymers-10-00664 [pii]
AID - 10.3390/polym10060664 [doi]
PST - epublish
SO  - Polymers (Basel). 2018 Jun 14;10(6):664. doi: 10.3390/polym10060664.