PMID- 30967579
OWN - NLM
STAT- MEDLINE
DCOM- 20201006
LR  - 20210109
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Apr 9
TI  - Therapeutic effects of a single injection of human umbilical mesenchymal stem 
      cells on acute and chronic colitis in mice.
PG  - 5832
LID - 10.1038/s41598-019-41910-x [doi]
LID - 5832
AB  - Multiple injections of bone marrow mesenchymal stem cells (BMMSCs) have been used 
      for treatment of chronic colitis in mice. We aimed to report the therapeutic 
      effects of a single injection of human umbilical cord mesenchymal stem cells 
      (hUCMSCs) on acute and chronic colitis. Male C57BL/6JNarl mice were divided into 
      control, phosphate-buffered saline (PBS), and hUCMSCs treated groups, 
      respectively. Acute and chronic colitis were induced in the mice (except 
      controls) using 3% dextran sulfate sodium (DSS). The mice in the hUCMSCs group 
      underwent a single injection of hUCMSCs. The disease activity index (DAI), colon 
      length, histology, colon inflammation score, in vivo stem cells images, and blood 
      cytokine levels were recorded. The DAI was significantly higher in the hUCMSCs 
      group than in the control group and lower than in the PBS group on all days. The 
      colon length was significantly longer and the colon inflammation score was 
      significantly lower in the hUCMSCs group than in the PBS group on days 8 and 25. 
      IL17A, Gro-alpha, MIP-1alpha, MIP-2, and eotaxin were significantly lower in the hUCMSCs 
      group than in the PBS group on days 8 and 25. Single-injection hUCMSCs improved 
      DSS-induced acute colitis and decreased progression of acute colitis to chronic 
      colitis.
FAU - Chang, Yu-Lung
AU  - Chang YL
AUID- ORCID: 0000-0002-7329-6944
AD  - Department of Urology, Taoyuan General Hospital, Ministry of Health and Welfare, 
      Taoyuan, Taiwan.
AD  - Department of Biomedical Engineering, College of Engineering, Chung Yuan 
      Christian University, Chung Li, Taiwan.
AD  - Department of Urology, School of Medicine, National Yang-Ming University, Taipei, 
      Taiwan.
AD  - Translational Medicine Center, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan.
FAU - Lo, Huei-Yu
AU  - Lo HY
AD  - Department of Rehabilitation, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan.
AD  - Translational Medicine Center, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan.
AD  - Department of Chemistry, Chung Yuan Christian University, Chung Li, Taiwan.
FAU - Cheng, Shun-Ping
AU  - Cheng SP
AD  - Department of Rehabilitation, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan.
AD  - Translational Medicine Center, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan.
FAU - Chang, Kuo-Ting
AU  - Chang KT
AD  - Translational Medicine Center, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan.
FAU - Lin, Xiu-Fang
AU  - Lin XF
AD  - Department of Biomedical Engineering, College of Engineering, Chung Yuan 
      Christian University, Chung Li, Taiwan.
FAU - Lee, Sheng-Ping
AU  - Lee SP
AD  - Department of Urology, Taoyuan General Hospital, Ministry of Health and Welfare, 
      Taoyuan, Taiwan.
FAU - Hsieh, Ming-Fa
AU  - Hsieh MF
AD  - Department of Biomedical Engineering, College of Engineering, Chung Yuan 
      Christian University, Chung Li, Taiwan. mfhsieh@cycu.edu.tw.
FAU - Chan, Chin-Kan
AU  - Chan CK
AD  - Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan. genejean620104@gmail.com.
AD  - Department of Biotechnology, School of Health Technology, Ming Chuan University, 
      Taoyuan, Taiwan. genejean620104@gmail.com.
AD  - Translational Medicine Center, Taoyuan General Hospital, Ministry of Health and 
      Welfare, Taoyuan, Taiwan. genejean620104@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190409
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - Colitis/*therapy
MH  - Disease Models, Animal
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - *Mesenchymal Stem Cells
MH  - Mice
MH  - Treatment Outcome
PMC - PMC6456500
COIS- The authors declare no competing interests.
EDAT- 2019/04/11 06:00
MHDA- 2020/10/07 06:00
PMCR- 2019/04/09
CRDT- 2019/04/11 06:00
PHST- 2018/09/21 00:00 [received]
PHST- 2019/03/20 00:00 [accepted]
PHST- 2019/04/11 06:00 [entrez]
PHST- 2019/04/11 06:00 [pubmed]
PHST- 2020/10/07 06:00 [medline]
PHST- 2019/04/09 00:00 [pmc-release]
AID - 10.1038/s41598-019-41910-x [pii]
AID - 41910 [pii]
AID - 10.1038/s41598-019-41910-x [doi]
PST - epublish
SO  - Sci Rep. 2019 Apr 9;9(1):5832. doi: 10.1038/s41598-019-41910-x.