PMID- 30968218
OWN - NLM
STAT- MEDLINE
DCOM- 20200225
LR  - 20200225
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 34
IP  - 10
DP  - 2019 Oct
TI  - Prevalence of Achilles tendon xanthoma and familial hypercholesterolemia in 
      patients with coronary artery disease undergoing percutaneous coronary 
      intervention.
PG  - 1595-1599
LID - 10.1007/s00380-019-01400-6 [doi]
AB  - Familial hypercholesterolemia (FH) is reportedly associated with the development 
      of coronary artery disease (CAD), especially acute coronary syndrome (ACS). 
      However, the prevalence of FH in patients with stable CAD is still unclear. The 
      aim of this study was to investigate the prevalence of Achilles tendon xanthoma 
      (ATX) and heterozygous FH in patients with stable CAD and ACS undergoing 
      percutaneous coronary intervention (PCI). A total of 423 patients with CAD (273 
      stable CAD and 150 ACS) undergoing PCI at Chiba University Hospital between June 
      2016 and February 2018 were enrolled in this study. Soft X-ray radiography of the 
      Achilles tendon was performed in all patients, and a maximum thickness of 9 mm or 
      more is regarded as ATX. Heterozygous FH was diagnosed according to the Japan 
      Atherosclerosis Society Guidelines. In comparisons between stable CAD and ACS 
      patients, ATX was observed in 9.2% vs. 15.3% (p = 0.055), and heterozygous FH was 
      diagnosed in 3.7% vs. 5.3% (p = 0.416), respectively. Among ACS patients, those 
      with ST elevation myocardial infarction (STEMI) showed the highest prevalence of 
      ATX (19.5%) and FH (7.3%). Whereas ATX and heterozygous FH were considerably 
      observed in patients with ACS, a certain number of ATX and heterozygous FH were 
      also detected in stable CAD patients.
FAU - Kitahara, Hideki
AU  - Kitahara H
AUID- ORCID: 0000-0002-2888-6160
AD  - Department of Cardiovascular Medicine, Chiba University Graduate School of 
      Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan. hkitahara@chiba-u.jp.
FAU - Mori, Naoto
AU  - Mori N
AD  - Department of Cardiovascular Medicine, Chiba University Graduate School of 
      Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.
FAU - Saito, Yuichi
AU  - Saito Y
AD  - Department of Cardiovascular Medicine, Chiba University Graduate School of 
      Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.
FAU - Nakayama, Takashi
AU  - Nakayama T
AD  - Department of Cardiovascular Medicine, Chiba University Graduate School of 
      Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.
FAU - Fujimoto, Yoshihide
AU  - Fujimoto Y
AD  - Department of Cardiovascular Medicine, Chiba University Graduate School of 
      Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.
FAU - Kobayashi, Yoshio
AU  - Kobayashi Y
AD  - Department of Cardiovascular Medicine, Chiba University Graduate School of 
      Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190409
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Achilles Tendon/*diagnostic imaging
MH  - Aged
MH  - Cholesterol, LDL/blood
MH  - Coronary Artery Disease/blood/*complications/surgery
MH  - Female
MH  - Humans
MH  - Hyperlipoproteinemia Type II/blood/*epidemiology
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - X-Rays
MH  - Xanthomatosis/diagnostic imaging/*epidemiology
OTO - NOTNLM
OT  - Achilles tendon xanthoma
OT  - Coronary artery disease
OT  - Familial hypercholesterolemia
EDAT- 2019/04/11 06:00
MHDA- 2020/02/26 06:00
CRDT- 2019/04/11 06:00
PHST- 2018/10/28 00:00 [received]
PHST- 2019/04/05 00:00 [accepted]
PHST- 2019/04/11 06:00 [pubmed]
PHST- 2020/02/26 06:00 [medline]
PHST- 2019/04/11 06:00 [entrez]
AID - 10.1007/s00380-019-01400-6 [pii]
AID - 10.1007/s00380-019-01400-6 [doi]
PST - ppublish
SO  - Heart Vessels. 2019 Oct;34(10):1595-1599. doi: 10.1007/s00380-019-01400-6. Epub 
      2019 Apr 9.