PMID- 30968254
OWN - NLM
STAT- MEDLINE
DCOM- 20200714
LR  - 20231213
IS  - 1612-9067 (Electronic)
IS  - 1612-9059 (Linking)
VI  - 16
IP  - 4
DP  - 2019 Oct
TI  - Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of 
      esophageal squamous cell carcinoma.
PG  - 333-344
LID - 10.1007/s10388-019-00669-w [doi]
AB  - BACKGROUND: Dendritic cells (DCs) are the most potent antigen-presenting cells to 
      induce cytotoxic T lymphocytes in the tumor environment. After acquiring 
      antigens, DCs undergo maturation and their expression of MHC and co-stimulation 
      molecules are enhanced, along with lysosome-associated membrane glycoprotein 3 
      (LAMP-3), which is a specific marker of mature DCs. In general, mature DCs are 
      usually considered to be immunostimulatory in the cancer microenvironment. In 
      addition, it is known that tumor-infiltrating lymphocytes (TILs) are associated 
      with a good prognosis in esophageal squamous cell carcinoma (ESCC). However, few 
      studies have targeted the interaction between DCs and TILs in the local immunity 
      of ESCC. We investigated the localization of mature DCs within ESCC tissue and 
      their relationship to TILs as well as the clinical outcome. METHODS: We evaluated 
      80 ESCC patients who underwent surgical treatment without preoperative treatment, 
      using immunohistochemistry with LAMP-3 and CD8. RESULTS: The results showed that 
      LAMP-3 DCs were predominantly observed in the peritumoral area. Intratumoral CD8 
      T cells were found to be associated with a favorable prognosis, and the number of 
      infiltrating LAMP-3 DCs was correlated with the number of intratumoral CD8 T 
      cells. CONCLUSION: At the local tumor site, mature LAMP-3 DCs might be associated 
      with increasing tumor infiltrating CD8 T cells.
FAU - Nishimura, Junya
AU  - Nishimura J
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Tanaka, Hiroaki
AU  - Tanaka H
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan. m1351176@med.osaka-cu.ac.jp.
FAU - Yamakoshi, Yoshihito
AU  - Yamakoshi Y
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Hiramatsu, Soichiro
AU  - Hiramatsu S
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Tamura, Tatsuro
AU  - Tamura T
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Toyokawa, Takahiro
AU  - Toyokawa T
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Muguruma, Kazuya
AU  - Muguruma K
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Maeda, Kiyoshi
AU  - Maeda K
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Hirakawa, Kosei
AU  - Hirakawa K
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
FAU - Ohira, Masaichi
AU  - Ohira M
AD  - Department of Surgical Oncology, Osaka City University Graduate School of 
      Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190409
PL  - Japan
TA  - Esophagus
JT  - Esophagus : official journal of the Japan Esophageal Society
JID - 101206627
RN  - 0 (LAMP3 protein, human)
RN  - 0 (Lysosomal Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Aged
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Carcinoma, Squamous Cell/immunology/*pathology
MH  - Dendritic Cells/immunology/metabolism/*pathology
MH  - Disease-Free Survival
MH  - Esophageal Neoplasms/immunology/*pathology
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lymphocytes, Tumor-Infiltrating/*immunology/metabolism
MH  - Lysosomal Membrane Proteins/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/metabolism
MH  - Proportional Hazards Models
MH  - Survival Rate
MH  - Tumor Microenvironment/*immunology
OTO - NOTNLM
OT  - Dendritic cell
OT  - Esophageal
OT  - LAMP-3
EDAT- 2019/04/11 06:00
MHDA- 2020/07/15 06:00
CRDT- 2019/04/11 06:00
PHST- 2018/08/17 00:00 [received]
PHST- 2019/03/28 00:00 [accepted]
PHST- 2019/04/11 06:00 [pubmed]
PHST- 2020/07/15 06:00 [medline]
PHST- 2019/04/11 06:00 [entrez]
AID - 10.1007/s10388-019-00669-w [pii]
AID - 10.1007/s10388-019-00669-w [doi]
PST - ppublish
SO  - Esophagus. 2019 Oct;16(4):333-344. doi: 10.1007/s10388-019-00669-w. Epub 2019 Apr 
      9.