PMID- 30968606
OWN - NLM
STAT- MEDLINE
DCOM- 20200526
LR  - 20240213
IS  - 2324-9269 (Electronic)
IS  - 2324-9269 (Linking)
VI  - 7
IP  - 6
DP  - 2019 Jun
TI  - Maternal genetic markers for risk of celiac disease and their potential 
      association with neural tube defects in offspring.
PG  - e688
LID - 10.1002/mgg3.688 [doi]
LID - e688
AB  - BACKGROUND: We examined the association between the maternal genotype for celiac 
      disease-associated variants and risk of neural tube defects (NTDs). METHODS: We 
      conducted a case-control study, using data from the National Birth Defects 
      Prevention Study. We evaluated 667 cases (women with an offspring with NTD) and 
      743 controls (women with an offspring without a birth defect). We classified 
      women as having low, intermediate, or high risk of celiac disease based on human 
      leukocyte antigen (HLA) variants. We used logistic regression to assess the 
      relationship between HLA celiac risk group (low, intermediate, high) and risk of 
      NTDs. Fifteen non-HLA variants (identified from genome-wide association studies 
      of celiac disease) were individually evaluated and modeled additively. RESULTS: 
      There was no association between HLA celiac risk group and NTDs (intermediate vs. 
      low risk: aOR, 1.0; 95% CI, 0.8-1.3; high vs. low risk: aOR, 0.8; 95% CI, 
      0.5-1.3). Of the fifteen non-HLA variants, we observed five significant 
      associations after accounting for multiple comparisons. Three negative 
      associations were observed with rs10903122, rs13314993, rs13151961 (aOR range: 
      0.69-0.81), and two positive associations were observed with rs13003464 and 
      rs11221332 (aOR range: 1.27-1.73). CONCLUSION: If confirmed, our results suggest 
      that the maternal variants related to celiac disease may be involved in the risk 
      of NTDs.
CI  - (c) 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley 
      Periodicals, Inc.
FAU - Hoang, Thanh T
AU  - Hoang TT
AD  - Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth 
      School of Public Health, Houston, Texas.
FAU - Lei, Yunping
AU  - Lei Y
AUID- ORCID: 0000-0003-1504-0884
AD  - Department of Molecular and Cellular Biology, Center for Precision Environmental 
      Health, Baylor College of Medicine, Houston, Texas.
FAU - Mitchell, Laura E
AU  - Mitchell LE
AD  - Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth 
      School of Public Health, Houston, Texas.
FAU - Sharma, Shreela V
AU  - Sharma SV
AD  - Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth 
      School of Public Health, Houston, Texas.
FAU - Swartz, Michael D
AU  - Swartz MD
AD  - Department of Biostatistics and Data Science, UTHealth School of Public Health, 
      Houston, Texas.
FAU - Waller, D Kim
AU  - Waller DK
AD  - Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth 
      School of Public Health, Houston, Texas.
FAU - Finnell, Richard H
AU  - Finnell RH
AD  - Department of Molecular and Cellular Biology, Center for Precision Environmental 
      Health, Baylor College of Medicine, Houston, Texas.
FAU - Benjamin, Renata H
AU  - Benjamin RH
AD  - Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth 
      School of Public Health, Houston, Texas.
FAU - Browne, Marilyn L
AU  - Browne ML
AD  - Congenital Malformations Registry, New York State Department of Health, Albany, 
      New York.
AD  - Department of Epidemiology and Biostatistics, University at Albany School of 
      Public Health, Rensselaer, New York.
FAU - Canfield, Mark A
AU  - Canfield MA
AUID- ORCID: 0000-0001-8827-1881
AD  - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State 
      Health Services, Austin, Texas.
FAU - Lupo, Philip J
AU  - Lupo PJ
AD  - Department of Pediatrics, Section of Hematology-Oncology, Baylor College of 
      Medicine, Houston, Texas.
FAU - McKenzie, Paige
AU  - McKenzie P
AD  - Department of Pediatrics, University of Texas Southwestern Medical Center, 
      Dallas, Texas.
FAU - Shaw, Gary M
AU  - Shaw GM
AD  - Department of Pediatrics, Stanford University School of Medicine, Stanford, 
      California.
FAU - Agopian, A J
AU  - Agopian AJ
AUID- ORCID: 0000-0002-5874-4155
AD  - Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth 
      School of Public Health, Houston, Texas.
CN  - National Birth Defects Prevention Study
LA  - eng
GR  - P30 DK056350/DK/NIDDK NIH HHS/United States
GR  - U01 DD000494/DD/NCBDD CDC HHS/United States
GR  - U01 DD001226/DD/NCBDD CDC HHS/United States
GR  - 5U01DD000494-03/CC/CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20190409
PL  - United States
TA  - Mol Genet Genomic Med
JT  - Molecular genetics & genomic medicine
JID - 101603758
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Celiac Disease/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Neural Tube Defects/*epidemiology/genetics
MH  - Polymorphism, Single Nucleotide
PMC - PMC6565562
OTO - NOTNLM
OT  - candidate genes
OT  - celiac disease
OT  - human leukocyte antigen
OT  - neural tube defects
OT  - pregnancy
COIS- The authors report no conflict of interest.
EDAT- 2019/04/11 06:00
MHDA- 2020/05/27 06:00
PMCR- 2019/04/09
CRDT- 2019/04/11 06:00
PHST- 2018/11/08 00:00 [received]
PHST- 2019/01/26 00:00 [revised]
PHST- 2019/03/06 00:00 [accepted]
PHST- 2019/04/11 06:00 [pubmed]
PHST- 2020/05/27 06:00 [medline]
PHST- 2019/04/11 06:00 [entrez]
PHST- 2019/04/09 00:00 [pmc-release]
AID - MGG3688 [pii]
AID - 10.1002/mgg3.688 [doi]
PST - ppublish
SO  - Mol Genet Genomic Med. 2019 Jun;7(6):e688. doi: 10.1002/mgg3.688. Epub 2019 Apr 
      9.