PMID- 30969030 OWN - NLM STAT- MEDLINE DCOM- 20200727 LR - 20210109 IS - 1939-3806 (Electronic) IS - 1939-3792 (Print) IS - 1939-3806 (Linking) VI - 12 IP - 6 DP - 2019 Jun TI - Maternal diabetes and hypertensive disorders in association with autism spectrum disorder. PG - 967-975 LID - 10.1002/aur.2105 [doi] AB - Previous studies have shown complications of pregnancy, often examined in aggregate, to be associated with autism spectrum disorder (ASD). Results for specific complications, such as maternal diabetes and hypertension, have not been uniformly consistent and should be investigated independently in relation to ASD in a large community-based sample. The Study to Explore Early Development (SEED), a US multisite case-control study, enrolled children born in 2003-2006 at 2-5 years of age. Children were classified into three groups based on confirmation of ASD (n = 698), non-ASD developmental delay (DD; n = 887), or controls drawn from the general population (POP; n = 979). Diagnoses of any diabetes or hypertensive disorder during pregnancy were identified from prenatal medical records and maternal self-report. Logistic regression models estimated adjusted odds ratios (aOR) and confidence intervals (CI) adjusting for maternal age, race/ethnicity, education, smoking during pregnancy, and study site. Models for hypertension were additionally adjusted for parity and plurality. Among 2,564 mothers, we identified 246 (9.6%) with any diabetes and 386 (15.1%) with any hypertension in pregnancy. After adjustment for covariates, any diabetes during pregnancy was not associated with ASD (aOR = 1.10 [95% CI 0.77, 1.56]), but any hypertension was associated with ASD (aOR = 1.69 [95% CI 1.26, 2.26]). Results were similar for DD, and any diabetes (aOR = 1.29 [95% CI 0.94, 1.78]) or any hypertension (aOR = 1.71 [95% CI 1.30, 2.25]). Some pregnancy complications, such as hypertension, may play a role in autism etiology and can possibly serve as a prompt for more vigilant ASD screening efforts. Autism Res 2019, 12: 967-975. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We studied if common complications in pregnancy are associated with autism spectrum disorder (ASD) in a large sample of mothers and children. Our results show an association between conditions marked by high blood pressure and ASD, but no association with conditions marked by high blood sugar and ASD. Associations were similar for children who had a developmental disorder that was not ASD, suggesting that this relationship may not be specific to ASD. CI - (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. FAU - Cordero, Christina AU - Cordero C AUID- ORCID: 0000-0003-1032-5303 AD - The University of North Carolina, Chapel Hill, North Carolina. FAU - Windham, Gayle C AU - Windham GC AUID- ORCID: 0000-0002-3882-8343 AD - California Department of Public Health, Richmond, California. FAU - Schieve, Laura A AU - Schieve LA AD - Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Fallin, Margaret Daniele AU - Fallin MD AD - Johns Hopkins University, Baltimore, Maryland. FAU - Croen, Lisa A AU - Croen LA AUID- ORCID: 0000-0001-7849-9428 AD - Kaiser Permanente, Oakland, California. FAU - Siega-Riz, Anna Maria AU - Siega-Riz AM AD - University of Virginia, Charlottesville, Virginia. FAU - Engel, Stephanie M AU - Engel SM AD - The University of North Carolina, Chapel Hill, North Carolina. FAU - Herring, Amy H AU - Herring AH AD - Duke University, Durham, North Carolina. FAU - Stuebe, Alison M AU - Stuebe AM AD - The University of North Carolina, Chapel Hill, North Carolina. FAU - Vladutiu, Catherine J AU - Vladutiu CJ AD - The University of North Carolina, Chapel Hill, North Carolina. FAU - Daniels, Julie L AU - Daniels JL AD - The University of North Carolina, Chapel Hill, North Carolina. LA - eng GR - T32 HD052468/HD/NICHD NIH HHS/United States GR - U10 DD000181/DD/NCBDD CDC HHS/United States GR - U10 DD000184/DD/NCBDD CDC HHS/United States GR - U01 DD000498/DD/NCBDD CDC HHS/United States GR - U01 DD001205/DD/NCBDD CDC HHS/United States GR - U10 DD000182/DD/NCBDD CDC HHS/United States GR - Michigan State University/International GR - U01DD001205/ACL/ACL HHS/United States GR - U10 DD000183/DD/NCBDD CDC HHS/United States GR - P30 ES010126/ES/NIEHS NIH HHS/United States GR - U10 DD000180/DD/NCBDD CDC HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. DEP - 20190410 PL - United States TA - Autism Res JT - Autism research : official journal of the International Society for Autism Research JID - 101461858 SB - IM MH - Adult MH - Autism Spectrum Disorder/*epidemiology MH - Case-Control Studies MH - Causality MH - Child, Preschool MH - Diabetes, Gestational/*epidemiology MH - Female MH - Humans MH - Hypertension, Pregnancy-Induced/*epidemiology MH - Logistic Models MH - Male MH - *Mothers MH - Odds Ratio MH - Pregnancy MH - United States/epidemiology PMC - PMC6546522 MID - NIHMS1021016 COIS- The authors do not have any conflicts of interest to report. EDAT- 2019/04/11 06:00 MHDA- 2020/07/28 06:00 PMCR- 2020/06/01 CRDT- 2019/04/11 06:00 PHST- 2018/08/16 00:00 [received] PHST- 2019/03/15 00:00 [revised] PHST- 2019/03/25 00:00 [accepted] PHST- 2019/04/11 06:00 [pubmed] PHST- 2020/07/28 06:00 [medline] PHST- 2019/04/11 06:00 [entrez] PHST- 2020/06/01 00:00 [pmc-release] AID - 10.1002/aur.2105 [doi] PST - ppublish SO - Autism Res. 2019 Jun;12(6):967-975. doi: 10.1002/aur.2105. Epub 2019 Apr 10.