PMID- 30970164
OWN - NLM
STAT- MEDLINE
DCOM- 20200421
LR  - 20200421
IS  - 1099-1344 (Electronic)
IS  - 0362-4803 (Linking)
VI  - 62
IP  - 6
DP  - 2019 May 30
TI  - Facile radiolabeling optimization process via design of experiments and an 
      intelligent optimization algorithm: Application for omeprazole radioiodination.
PG  - 280-287
LID - 10.1002/jlcr.3734 [doi]
AB  - The major uses of radiopharmaceuticals (RP) in clinical areas are diagnosis 
      and/or therapy. The present study aimed to utilize the application of fractional 
      factorial design analysis (FFDA) coupled with particle swarm optimization 
      algorithm (PSO) to assess the optimization of RP production process. In this 
      regard, omeprazole (OMP), which is gastric parietal cell proton pump inhibitor 
      (PPI), was radiolabeled with iodine-125 ((125) I) isotope in order to be used as 
      a radiotracer for stomach imaging. Different factors that affect radiolabeling 
      process were studied. According to the proposed design, just 16 experimental runs 
      of radiolabeling process were performed using the extremes of each factor. In 
      addition, one run was executed at the mean point of each factor. Undesirable 
      maximum radiolabeling yield (RY) of radioiodinated omeprazole ((125) I-OMP) was 
      deduced from application of FFDA (88.4%). Furthermore, after applying PSO with 
      changing limits of one factor, the maximum RY of (125) I-OMP was found to be 
      93.78%. Moreover, the practically verification from optimum conditions, which 
      obtained from PSO, was found to give an RY of 93.99%. Overall, the findings of 
      this study confirmed the potential use of that hybrid design for optimization of 
      radiolabeling processes.
CI  - (c) 2019 John Wiley & Sons, Ltd.
FAU - Farrag, Nourihan S
AU  - Farrag NS
AUID- ORCID: 0000-0002-8133-7224
AD  - Labeled Compounds Department, Hot Labs. Center, Atomic Energy Authority, Cairo, 
      Egypt.
FAU - Abdel-Halim, Hala A
AU  - Abdel-Halim HA
AD  - Radioactive Waste Management Department, Hot Labs. Center, Atomic Energy 
      Authority, Cairo, Egypt.
FAU - Abdel Moamen, Ola A
AU  - Abdel Moamen OA
AD  - Radioactive Waste Management Department, Hot Labs. Center, Atomic Energy 
      Authority, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190520
PL  - England
TA  - J Labelled Comp Radiopharm
JT  - Journal of labelled compounds & radiopharmaceuticals
JID - 7610510
RN  - 0 (Iodine Radioisotopes)
RN  - GVO776611R (Iodine-125)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - *Algorithms
MH  - Drug Stability
MH  - *Halogenation
MH  - Hydrogen-Ion Concentration
MH  - Iodine Radioisotopes/*chemistry
MH  - Isotope Labeling/methods
MH  - Kinetics
MH  - Omeprazole/*chemistry
MH  - Radiochemistry
MH  - Temperature
OTO - NOTNLM
OT  - fractional factorial design
OT  - omeprazole
OT  - particle swarm optimization
OT  - radiolabeling
EDAT- 2019/04/11 06:00
MHDA- 2020/04/22 06:00
CRDT- 2019/04/11 06:00
PHST- 2019/03/23 00:00 [received]
PHST- 2019/04/04 00:00 [revised]
PHST- 2019/04/04 00:00 [accepted]
PHST- 2019/04/11 06:00 [pubmed]
PHST- 2020/04/22 06:00 [medline]
PHST- 2019/04/11 06:00 [entrez]
AID - 10.1002/jlcr.3734 [doi]
PST - ppublish
SO  - J Labelled Comp Radiopharm. 2019 May 30;62(6):280-287. doi: 10.1002/jlcr.3734. 
      Epub 2019 May 20.