PMID- 30970729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 9
IP  - 2
DP  - 2017 Feb 4
TI  - Polyion Complex Vesicles with Solvated Phosphobetaine Shells Formed from 
      Oppositely Charged Diblock Copolymers.
LID - 10.3390/polym9020049 [doi]
LID - 49
AB  - Diblock copolymers consisting of a hydrophilic poly(2-(methacryloyloxy)ethyl 
      phosphorylcholine) (PMPC) block and either a cationic or anionic block were 
      prepared from (3-(methacrylamido)propyl)trimethylammonium chloride (MAPTAC) or 
      sodium 2-(acrylamido)-2-methylpropanesulfonate (AMPS). Polymers were synthesized 
      via reversible addition-fragmentation chain transfer (RAFT) radical 
      polymerization using a PMPC macro-chain transfer agent. The degree of 
      polymerization for PMPC, cationic PMAPTAC, and anionic PAMPS blocks was 20, 190, 
      and 196, respectively. Combining two solutions of oppositely charged diblock 
      copolymers, PMPC-b-PMAPTAC and PMPC-b-PAMPS, led to the spontaneous formation of 
      polyion complex vesicles (PICsomes). The PICsomes were characterized using (1)H 
      NMR, static abd dynamic light scattering, transmittance electron microscopy 
      (TEM), and atomic force microscopy. Maximum hydrodynamic radius (R(h)) for the 
      PICsome was observed at a neutral charge balance of the cationic and anionic 
      diblock copolymers. The R(h) value and aggregation number (N(agg)) of PICsomes in 
      0.1 M NaCl was 78.0 nm and 7770, respectively. A spherical hollow vesicle 
      structure was observed in TEM images. The hydrodynamic size of the PICsomes 
      increased with concentration of the diblock copolymer solutions before mixing. 
      Thus, the size of the PICsomes can be controlled by selecting an appropriate 
      preparation method.
FAU - Nakai, Keita
AU  - Nakai K
AD  - Department of Applied Chemistry, University of Hyogo, 2167 Shosha, Himeji, Hyogo 
      671-2280, Japan. good.west.56@hotmail.co.jp.
FAU - Ishihara, Kazuhiko
AU  - Ishihara K
AD  - Department of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo 113-8656, Japan. ishihara@mpc.t.u-tokyo.ac.jp.
FAU - Kappl, Michael
AU  - Kappl M
AUID- ORCID: 0000-0001-7335-1707
AD  - Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. 
      kappl@mpip-mainz.mpg.de.
FAU - Fujii, Syuji
AU  - Fujii S
AUID- ORCID: 0000-0003-2562-9502
AD  - Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of 
      Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan. syuji.fujii@oit.ac.jp.
FAU - Nakamura, Yoshinobu
AU  - Nakamura Y
AD  - Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of 
      Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan. 
      yoshinobu.nakamura@oit.ac.jp.
FAU - Yusa, Shin-Ichi
AU  - Yusa SI
AUID- ORCID: 0000-0002-2838-5200
AD  - Department of Applied Chemistry, University of Hyogo, 2167 Shosha, Himeji, Hyogo 
      671-2280, Japan. yusa@eng.u-hyogo.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20170204
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC6432163
OTO - NOTNLM
OT  - RAFT polymerization
OT  - block copolymers
OT  - polyion complex
OT  - vesicle
OT  - water-soluble polymers
COIS- The authors declare no conflict of interest.
EDAT- 2017/02/04 00:00
MHDA- 2017/02/04 00:01
PMCR- 2017/02/04
CRDT- 2019/04/12 06:00
PHST- 2016/12/31 00:00 [received]
PHST- 2017/01/24 00:00 [revised]
PHST- 2017/01/30 00:00 [accepted]
PHST- 2019/04/12 06:00 [entrez]
PHST- 2017/02/04 00:00 [pubmed]
PHST- 2017/02/04 00:01 [medline]
PHST- 2017/02/04 00:00 [pmc-release]
AID - polym9020049 [pii]
AID - polymers-09-00049 [pii]
AID - 10.3390/polym9020049 [doi]
PST - epublish
SO  - Polymers (Basel). 2017 Feb 4;9(2):49. doi: 10.3390/polym9020049.